Materials Science and Engineering C, volume 108, pages 110494
PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity
Popov Anton L.
1
,
Han Bingyuan
2
,
Ermakov Artem M.
1
,
Savintseva I V
1
,
Ermakova Olga N
1
,
Popova Nadezhda
1
,
Istomin Sergey Ya.
4, 5
,
Ivanova Oxana
6
,
Kozlov Daniil A.
4, 5
,
Ivanov V. V.
7, 8
3
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine,Kyiv D0368,Ukraine
|
Publication type: Journal Article
Publication date: 2020-03-01
Journal:
Materials Science and Engineering C
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.9
ISSN: 09284931, 18730191
Bioengineering
Biomaterials
Mechanics of Materials
Abstract
Photochromic tungsten oxide (WO3) nanoparticles stabilized by polyvinylpyrrolidone (PVP) were synthesized to evaluate their potential for biomedical applications. PVP-stabilized tungsten oxide nanoparticles demonstrated a highly selective cytotoxic effect on normal and cancer cells in vitro. WO3 nanoparticles were found to induce substantial cell death in osteosarcoma cells (MNNG/HOS cell line) with a half-maximal inhibitory concentration (IC50) of 5 mg/mL, while producing no, or only minor, toxicity in healthy human mesenchymal stem cells (hMSc). WO3 nanoparticles induced intracellular oxidative stress, which led to apoptosis type cell death. The selective anti-cancer effects of WO3 nanoparticles are due to the pH sensitivity of tungsten oxide and its capability of reactive oxygen species (ROS) generation, which is expressed in the modulation of genes involved in reactive oxygen species metabolism, mitochondrial dysfunction, and apoptosis.
Citations by journals
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3
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Russian Journal of Inorganic Chemistry
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Russian Journal of Inorganic Chemistry
3 publications, 14.29%
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Molecules
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Molecules
1 publication, 4.76%
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Journal of Functional Biomaterials
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Journal of Functional Biomaterials
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
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Frontiers in Molecular Biosciences
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Frontiers in Molecular Biosciences
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Journal of Applied Genetics
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Nano Convergence
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Nano Convergence
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Journal of Molecular Structure
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Journal of Molecular Structure
1 publication, 4.76%
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Journal of Nanobiotechnology
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Journal of Nanobiotechnology
1 publication, 4.76%
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Materials Today Communications
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1 publication, 4.76%
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Process Biochemistry
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Process Biochemistry
1 publication, 4.76%
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Advanced healthcare materials
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1 publication, 4.76%
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Orthopaedic surgery
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1 publication, 4.76%
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Advanced Materials
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Advanced Materials
1 publication, 4.76%
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Advanced Optical Materials
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Advanced Optical Materials
1 publication, 4.76%
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Biomedicines
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Biomedicines
1 publication, 4.76%
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Biomaterials Science
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Biomaterials Science
1 publication, 4.76%
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Australian Journal of Chemistry
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Australian Journal of Chemistry
1 publication, 4.76%
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1
2
3
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 19.05%
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Wiley
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Wiley
4 publications, 19.05%
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Pleiades Publishing
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Pleiades Publishing
3 publications, 14.29%
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Springer Nature
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Springer Nature
3 publications, 14.29%
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Elsevier
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Elsevier
3 publications, 14.29%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 4.76%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 4.76%
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CSIRO Publishing
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CSIRO Publishing
1 publication, 4.76%
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1
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3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Popov A. L. et al. PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity // Materials Science and Engineering C. 2020. Vol. 108. p. 110494.
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Popov A. L., Han B., Ermakov A. M., Savintseva I. V., Ermakova O. N., Popova N., Shcherbakov A. B., Istomin S. Y., Ivanova O., Kozlov D. A., Baranchikov A. E., Ivanov V. V. PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity // Materials Science and Engineering C. 2020. Vol. 108. p. 110494.
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TY - JOUR
DO - 10.1016/j.msec.2019.110494
UR - https://doi.org/10.1016%2Fj.msec.2019.110494
TI - PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity
T2 - Materials Science and Engineering C
AU - Popov, Anton L.
AU - Han, Bingyuan
AU - Ermakov, Artem M.
AU - Savintseva, I V
AU - Ermakova, Olga N
AU - Popova, Nadezhda
AU - Shcherbakov, Alexander B.
AU - Istomin, Sergey Ya.
AU - Ivanova, Oxana
AU - Kozlov, Daniil A.
AU - Baranchikov, Alexander E
AU - Ivanov, V. V.
PY - 2020
DA - 2020/03/01 00:00:00
PB - Elsevier
SP - 110494
VL - 108
SN - 0928-4931
SN - 1873-0191
ER -
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@article{2020_Popov,
author = {Anton L. Popov and Bingyuan Han and Artem M. Ermakov and I V Savintseva and Olga N Ermakova and Nadezhda Popova and Alexander B. Shcherbakov and Sergey Ya. Istomin and Oxana Ivanova and Daniil A. Kozlov and Alexander E Baranchikov and V. V. Ivanov},
title = {PVP-stabilized tungsten oxide nanoparticles: pH sensitive anti-cancer platform with high cytotoxicity},
journal = {Materials Science and Engineering C},
year = {2020},
volume = {108},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016%2Fj.msec.2019.110494},
pages = {110494},
doi = {10.1016/j.msec.2019.110494}
}