Materials Science and Engineering C, volume 120, pages 111717

Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics

Zelepukin Ivan V ^{1, 2, 3}

Popov Anton ⁴

Shipunova Victoria O ^{1, 2, 3}

Tikhonowski Gleb V. ⁴

Mirkasymov Aziz B ^{1, 3}

Popova Kuznetsova Elena A ⁴

Klimentov Sergey M ⁴

Kabashin Andrei V. ^{1, 5}

Deyev S. M. ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), Moscow, Russia |

Moscow Institute of Physics and Technology, Dolgoprudny, Russia |

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, Moscow, Russia |

⁴

MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), Moscow, Russia. |

⁵

Aix-Marseille University, CNRS, LP3, Marseille, France |

Publication type: Journal Article

Publication date: 2021-01-01

Elsevier

Journal: Materials Science and Engineering C

Quartile SCImago

Quartile WOS

Impact factor: 7.9

ISSN: 09284931, 18730191

DOI: 10.1016/j.msec.2020.111717

Copy DOI

Bioengineering

Biomaterials

Mechanics of Materials

Abstract

Having plasmonic absorption within the biological transparency window, titanium nitride (TiN) nanoparticles (NPs) can potentially outperform gold counterparts in phototheranostic applications, but characteristics of available TiN NPs are still far from required parameters. Recently emerged laser-ablative synthesis opens up opportunities to match these parameters as it makes possible the production of ultrapure low size-dispersed spherical TiN NPs, capable of generating a strong phototherapy effect under 750–800 nm excitation. This study presents the first assessment of toxicity, biodistribution and pharmacokinetics of laser-synthesized TiN NPs. Tests in vitro using 8 cell lines from different tissues evidenced safety of both as-synthesized and PEG-coated NPs (TiN-PEG NPs). After systemic administration in mice, they mainly accumulated in liver and spleen, but did not cause any sign of toxicity or organ damage up to concentration of 6 mg kg−1, which was confirmed by the invariability of blood biochemical parameters, weight and hemotoxicity examination. The NPs demonstrated efficient passive accumulation in EMT6/P mammary tumor, while concentration of TiN-PEG NPs was 2.2-fold higher due to “stealth” effect yielding 7-times longer circulation in blood. The obtained results evidence high safety of laser-synthesized TiN NPs for biological systems, which promises a major advancement of phototheranostic modalities on their basis.

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Citations by journals

	1 2 3 4 5 6
Bulletin of the Lebedev Physics Institute	Bulletin of the Lebedev Physics Institute, 6, 13.64% Bulletin of the Lebedev Physics Institute 6 publications, 13.64%
Nanomaterials	Nanomaterials, 5, 11.36% Nanomaterials 5 publications, 11.36%
Pharmaceutics	Pharmaceutics, 3, 6.82% Pharmaceutics 3 publications, 6.82%
Proceedings of SPIE - The International Society for Optical Engineering	Proceedings of SPIE - The International Society for Optical Engineering, 2, 4.55% Proceedings of SPIE - The International Society for Optical Engineering 2 publications, 4.55%
Acta Naturae	Acta Naturae, 2, 4.55% Acta Naturae 2 publications, 4.55%
Applied Physics Reviews	Applied Physics Reviews, 1, 2.27% Applied Physics Reviews 1 publication, 2.27%
Applied Physics Letters	Applied Physics Letters, 1, 2.27% Applied Physics Letters 1 publication, 2.27%
Crystals	Crystals, 1, 2.27% Crystals 1 publication, 2.27%
Journal of the Electrochemical Society	Journal of the Electrochemical Society, 1, 2.27% Journal of the Electrochemical Society 1 publication, 2.27%
Journal of Physics: Conference Series	Journal of Physics: Conference Series, 1, 2.27% Journal of Physics: Conference Series 1 publication, 2.27%
Molecules	Molecules, 1, 2.27% Molecules 1 publication, 2.27%
Frontiers in Materials	Frontiers in Materials, 1, 2.27% Frontiers in Materials 1 publication, 2.27%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 2.27% Frontiers in Chemistry 1 publication, 2.27%
Frontiers of Materials Science	Frontiers of Materials Science, 1, 2.27% Frontiers of Materials Science 1 publication, 2.27%
Light: Science and Applications	Light: Science and Applications, 1, 2.27% Light: Science and Applications 1 publication, 2.27%
Scientific Reports	Scientific Reports, 1, 2.27% Scientific Reports 1 publication, 2.27%
Trends in Chemistry	Trends in Chemistry, 1, 2.27% Trends in Chemistry 1 publication, 2.27%
Talanta Open	Talanta Open, 1, 2.27% Talanta Open 1 publication, 2.27%
Chemosphere	Chemosphere, 1, 2.27% Chemosphere 1 publication, 2.27%
Advanced Optical Materials	Advanced Optical Materials, 1, 2.27% Advanced Optical Materials 1 publication, 2.27%
Journal of Biomedical Materials Research - Part A	Journal of Biomedical Materials Research - Part A, 1, 2.27% Journal of Biomedical Materials Research - Part A 1 publication, 2.27%
International Journal of Nanomedicine	International Journal of Nanomedicine, 1, 2.27% International Journal of Nanomedicine 1 publication, 2.27%
ACS Omega	ACS Omega, 1, 2.27% ACS Omega 1 publication, 2.27%
Chemistry of Materials	Chemistry of Materials, 1, 2.27% Chemistry of Materials 1 publication, 2.27%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 2.27% Journal of Materials Chemistry B 1 publication, 2.27%
Inorganic and Nano-Metal Chemistry	Inorganic and Nano-Metal Chemistry, 1, 2.27% Inorganic and Nano-Metal Chemistry 1 publication, 2.27%
Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications	Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications, 1, 2.27% Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications 1 publication, 2.27%
Engineering	Engineering, 1, 2.27% Engineering 1 publication, 2.27%
Journal of Physical Chemistry Letters	Journal of Physical Chemistry Letters, 1, 2.27% Journal of Physical Chemistry Letters 1 publication, 2.27%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 10, 22.73% Multidisciplinary Digital Publishing Institute (MDPI) 10 publications, 22.73%
Pleiades Publishing	Pleiades Publishing, 6, 13.64% Pleiades Publishing 6 publications, 13.64%
Elsevier	Elsevier, 5, 11.36% Elsevier 5 publications, 11.36%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 6.82% American Chemical Society (ACS) 3 publications, 6.82%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 2, 4.55% American Institute of Physics (AIP) 2 publications, 4.55%
SPIE	SPIE, 2, 4.55% SPIE 2 publications, 4.55%
Frontiers Media S.A.	Frontiers Media S.A., 2, 4.55% Frontiers Media S.A. 2 publications, 4.55%
Springer Nature	Springer Nature, 2, 4.55% Springer Nature 2 publications, 4.55%
Wiley	Wiley, 2, 4.55% Wiley 2 publications, 4.55%
Acta Naturae Ltd	Acta Naturae Ltd, 2, 4.55% Acta Naturae Ltd 2 publications, 4.55%
The Electrochemical Society	The Electrochemical Society, 1, 2.27% The Electrochemical Society 1 publication, 2.27%
IOP Publishing	IOP Publishing, 1, 2.27% IOP Publishing 1 publication, 2.27%
Higher Education Press	Higher Education Press, 1, 2.27% Higher Education Press 1 publication, 2.27%
Dove Medical Press	Dove Medical Press, 1, 2.27% Dove Medical Press 1 publication, 2.27%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.27% Royal Society of Chemistry (RSC) 1 publication, 2.27%
Taylor & Francis	Taylor & Francis, 1, 2.27% Taylor & Francis 1 publication, 2.27%
	2 4 6 8 10

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Zelepukin I. V. et al. Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics // Materials Science and Engineering C. 2021. Vol. 120. p. 111717.

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Zelepukin I. V., Popov A., Shipunova V. O., Tikhonowski G. V., Mirkasymov A. B., Popova Kuznetsova E. A., Klimentov S. M., Kabashin A. V., Deyev S. M. Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics // Materials Science and Engineering C. 2021. Vol. 120. p. 111717.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.msec.2020.111717

UR - https://doi.org/10.1016%2Fj.msec.2020.111717

TI - Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics

T2 - Materials Science and Engineering C

AU - Zelepukin, Ivan V

AU - Popov, Anton

AU - Shipunova, Victoria O

AU - Tikhonowski, Gleb V.

AU - Mirkasymov, Aziz B

AU - Popova Kuznetsova, Elena A

AU - Klimentov, Sergey M

AU - Kabashin, Andrei V.

AU - Deyev, S. M.

PY - 2021

DA - 2021/01/01 00:00:00

PB - Elsevier

SP - 111717

VL - 120

SN - 0928-4931

SN - 1873-0191

ER -

BibTex

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BibTex Copy

@article{2021_Zelepukin,

author = {Ivan V Zelepukin and Anton Popov and Victoria O Shipunova and Gleb V. Tikhonowski and Aziz B Mirkasymov and Elena A Popova Kuznetsova and Sergey M Klimentov and Andrei V. Kabashin and S. M. Deyev},

title = {Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics},

journal = {Materials Science and Engineering C},

year = {2021},

volume = {120},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016%2Fj.msec.2020.111717},

pages = {111717},

doi = {10.1016/j.msec.2020.111717}

}

Found error?

Publisher

Elsevier

Journal

Materials Science and Engineering C

Quartile SCImago

Quartile WOS

Impact factor

7.9

ISSN

09284931 (Print)
18730191 (Electronic)

Labs

Bionanophotonics Laboratory

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