Open Access

Materials Today Advances, volume 14, pages 100214

Calcium carbonate vaterite particles for drug delivery: Advances and challenges

Trushina Daria ^{1, 2}

Borodina T N ¹

Belyakov Sergei ³

Antipina Maria N. ⁴

Hide authors affiliations Show authors affiliations: 4 affiliations

A.V. Shubnikov Institute of Crystallography of Federal Research Centre “Crystallography and Photonics” of Russian Academy of Sciences, Russian Academy of Sciences, Moscow, 119333, Russia

FSRC "Crystallography and photonics" of NRC «Kurchatov Institute»

Shubnikov Institute of Crystallography

I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia |

Theracross Technologies Pte Ltd, 251 Pasir Panjang Rd, Singapore, 118610, Singapore |

⁴

Singapore Institute of Food and Biotechnology Innovation A∗STAR, 31 Biopolis Way, #01-02 Nanos, Singapore, 138669, Singapore |

Publication type: Journal Article

Publication date: 2022-06-01

Elsevier

Journal: Materials Today Advances

Quartile SCImago

Quartile WOS

Impact factor: 10

ISSN: 25900498

DOI: 10.1016/j.mtadv.2022.100214

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General Materials Science

Mechanical Engineering

Abstract

The recent successful application of lipid-based nanoparticles as delivery vehicles in COVID-19 vaccines demonstrated the superior potential of nanoparticle-based technology for targeted drug delivery in biomedicine. Among novel, rapidly advancing delivery platforms, the inorganic nano/microparticles gradually reach new heights and attract well-deserved attention among scientists and clinicians. Calcium carbonate in its vaterite form is used as a biocompatible carrier for a progressively increasing number of biomedical applications. Its growing popularity is conferred by beneficial porosity of particles, high mechanical stability, biodegradability under certain physiological conditions, ability to provide a continuous steady release of bioactives, preferential safety profile, and low cost, which make calcium carbonate a suitable entity of highly efficacious formulations for controlled drug delivery and release. The focal point of the current review is the success of the recent vaterite applications in the delivery of various diagnostics and therapeutic drugs. The manuscript highlights the nuances of drug loading in vaterite particles, connecting it with particle morphology, size, and charge of the loaded molecules, payload concentration, mono- or multiple drug loading. The manuscript also depicts recent successful methods of increasing the loading capacity developed for vaterite carriers. In addition, the review describes the various administration routes for vaterite particles with bioactive payloads, which were reported in recent years. Special attention is given to the multi-drug-loaded vaterite particles (“molecular cocktails”) and reports on their successful delivery in vitro and in vivo . • Vaterite is a safe and multifaceted delivery platform for pharmaceutical biologics. • The loading protocol is specially designed for a particular bioactive compound. • Particle freezing, combined adsorption/centrifugation, or doping increase loading. • Vaterite nanoparticles can perform targeted drug delivery in cancer treatment. • CaCO 3 is an efficient delivery system for invasive and non-invasive administration.

By date By citations

Citations by journals

	1 2
Crystal Growth and Design	Crystal Growth and Design, 2, 6.9% Crystal Growth and Design 2 publications, 6.9%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 6.9% International Journal of Molecular Sciences 2 publications, 6.9%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 2, 6.9% Frontiers in Bioengineering and Biotechnology 2 publications, 6.9%
Pharmaceutics	Pharmaceutics, 2, 6.9% Pharmaceutics 2 publications, 6.9%
Crystallography Reports	Crystallography Reports, 2, 6.9% Crystallography Reports 2 publications, 6.9%
Cancer Nanotechnology	Cancer Nanotechnology, 1, 3.45% Cancer Nanotechnology 1 publication, 3.45%
Nanomaterials	Nanomaterials, 1, 3.45% Nanomaterials 1 publication, 3.45%
Frontiers in Materials	Frontiers in Materials, 1, 3.45% Frontiers in Materials 1 publication, 3.45%
LWT - Food Science and Technology	LWT - Food Science and Technology, 1, 3.45% LWT - Food Science and Technology 1 publication, 3.45%
ACS Infectious Diseases	ACS Infectious Diseases, 1, 3.45% ACS Infectious Diseases 1 publication, 3.45%
ACS Applied Nano Materials	ACS Applied Nano Materials, 1, 3.45% ACS Applied Nano Materials 1 publication, 3.45%
Exploration	Exploration, 1, 3.45% Exploration 1 publication, 3.45%
Heliyon	Heliyon, 1, 3.45% Heliyon 1 publication, 3.45%
Cement and Concrete Research	Cement and Concrete Research, 1, 3.45% Cement and Concrete Research 1 publication, 3.45%
Cancers	Cancers, 1, 3.45% Cancers 1 publication, 3.45%
Small	Small, 1, 3.45% Small 1 publication, 3.45%
Minerals	Minerals, 1, 3.45% Minerals 1 publication, 3.45%
Environmental Science and Pollution Research	Environmental Science and Pollution Research, 1, 3.45% Environmental Science and Pollution Research 1 publication, 3.45%
Separation and Purification Technology	Separation and Purification Technology, 1, 3.45% Separation and Purification Technology 1 publication, 3.45%
CrystEngComm	CrystEngComm, 1, 3.45% CrystEngComm 1 publication, 3.45%
Nature Communications	Nature Communications, 1, 3.45% Nature Communications 1 publication, 3.45%
Materials Advances	Materials Advances, 1, 3.45% Materials Advances 1 publication, 3.45%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 1, 3.45% Applied Sciences (Switzerland) 1 publication, 3.45%
ACS Omega	ACS Omega, 1, 3.45% ACS Omega 1 publication, 3.45%
	1 2

Citations by publishers

	1 2 3 4 5 6 7 8
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 8, 27.59% Multidisciplinary Digital Publishing Institute (MDPI) 8 publications, 27.59%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 17.24% American Chemical Society (ACS) 5 publications, 17.24%
Elsevier	Elsevier, 4, 13.79% Elsevier 4 publications, 13.79%
Springer Nature	Springer Nature, 3, 10.34% Springer Nature 3 publications, 10.34%
Frontiers Media S.A.	Frontiers Media S.A., 3, 10.34% Frontiers Media S.A. 3 publications, 10.34%
Wiley	Wiley, 2, 6.9% Wiley 2 publications, 6.9%
Pleiades Publishing	Pleiades Publishing, 2, 6.9% Pleiades Publishing 2 publications, 6.9%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 6.9% Royal Society of Chemistry (RSC) 2 publications, 6.9%
	1 2 3 4 5 6 7 8

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Trushina D. et al. Calcium carbonate vaterite particles for drug delivery: Advances and challenges // Materials Today Advances. 2022. Vol. 14. p. 100214.

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Trushina D., Borodina T. N., Belyakov S., Antipina M. N. Calcium carbonate vaterite particles for drug delivery: Advances and challenges // Materials Today Advances. 2022. Vol. 14. p. 100214.

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RIS Copy

TY - JOUR

DO - 10.1016/j.mtadv.2022.100214

UR - https://doi.org/10.1016%2Fj.mtadv.2022.100214

TI - Calcium carbonate vaterite particles for drug delivery: Advances and challenges

T2 - Materials Today Advances

AU - Trushina, Daria

AU - Borodina, T N

AU - Belyakov, Sergei

AU - Antipina, Maria N.

PY - 2022

DA - 2022/06/01 00:00:00

PB - Elsevier

SP - 100214

VL - 14

SN - 2590-0498

ER -

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BibTex Copy

@article{2022_Trushina,

author = {Daria Trushina and T N Borodina and Sergei Belyakov and Maria N. Antipina},

title = {Calcium carbonate vaterite particles for drug delivery: Advances and challenges},

journal = {Materials Today Advances},

year = {2022},

volume = {14},

publisher = {Elsevier},

month = {jun},

url = {https://doi.org/10.1016%2Fj.mtadv.2022.100214},

pages = {100214},

doi = {10.1016/j.mtadv.2022.100214}

}

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Publisher

Elsevier

Journal

Materials Today Advances

Quartile SCImago

Quartile WOS

Impact factor

ISSN

25900498 (Electronic)

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