Microvascular Research, volume 120, pages 13-20

Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus

Publication typeJournal Article
Publication date2018-11-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor3.1
ISSN00262862, 10959319
Biochemistry
Cell Biology
Cardiology and Cardiovascular Medicine
Abstract
Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In this study Laser Doppler flowmetry, a noninvasive technique for the cutaneous blood flow monitoring, was utilized together with local temperature tests and wavelet analysis. The study of the blood flow in the microvascular bed of toes was carried out in the control group of 40 healthy subjects and in two groups of 17 type 1 and 23 type 2 diabetic patients. The local temperature tests demonstrated that the diabetic patients have impaired vasodilation in response to local heating. The tendency for impaired low frequency pulsations of the blood flow associated with endothelial and neurogenic activities in both diabetes groups was observed. Local thermal tests induced variations in perfusion and its spectral characteristics, which were different in the groups under study. In our opinion, the obtained preliminary results can be a basis for further research and provide a deeper understanding of pathological processes that drive microvascular abnormalities caused by diabetes mellitus.

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GOST Copy
Mizeva I. et al. Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus // Microvascular Research. 2018. Vol. 120. pp. 13-20.
GOST all authors (up to 50) Copy
Mizeva I., Zharkikh E. V., Dremin V., Zherebtsov E. A., Makovik I., Potapova E. V., Dunaev A. V. Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus // Microvascular Research. 2018. Vol. 120. pp. 13-20.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.mvr.2018.05.005
UR - https://doi.org/10.1016%2Fj.mvr.2018.05.005
TI - Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus
T2 - Microvascular Research
AU - Mizeva, I.
AU - Zharkikh, Elena V.
AU - Dremin, Viktor
AU - Zherebtsov, Evgeny A.
AU - Makovik, Irina
AU - Potapova, Elena V.
AU - Dunaev, Andrey V.
PY - 2018
DA - 2018/11/01 00:00:00
PB - Elsevier
SP - 13-20
VL - 120
SN - 0026-2862
SN - 1095-9319
ER -
BibTex
Cite this
BibTex Copy
@article{2018_Mizeva,
author = {I. Mizeva and Elena V. Zharkikh and Viktor Dremin and Evgeny A. Zherebtsov and Irina Makovik and Elena V. Potapova and Andrey V. Dunaev},
title = {Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus},
journal = {Microvascular Research},
year = {2018},
volume = {120},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.mvr.2018.05.005},
pages = {13--20},
doi = {10.1016/j.mvr.2018.05.005}
}
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