Nanomedicine: Nanotechnology, Biology, and Medicine, volume 25, pages 102171
Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination
Garanina A. S.
1, 2
,
Naumenko Victor
3, 4
,
Nikitin Alexey A.
5, 6
,
Myrovali E
7
,
Petukhova Anna Y
8
,
Klimyuk Svetlana V
8
,
Nalench Yulia A
8
,
Ilyasov Artem R
8
,
Erofeev Alexander V.
5, 6
,
Gorelkin Peter
9
,
Angelakeris Mavroeidis
7
,
Wiedwald U.
4, 10
,
Majouga Alexander G.
2, 4, 11
,
Abakumov Maxim A.
4, 12
7
School of Physics, Aristotle University of Thessaloniki, Thessaloniki (Greece)
|
9
Medical Nanotechnology LLC, Skolkovo Innovation Center, Moscow, Russia.
|
10
Faculty of Physics and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany.
|
Publication type: Journal Article
Publication date: 2020-04-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 15499634, 15499642
Medicine (miscellaneous)
Pharmaceutical Science
Molecular Medicine
General Materials Science
Bioengineering
Biomedical Engineering
Abstract
Magnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models - breast (4T1) and colon (CT26) cancer in vitro and in vivo. The overall MHT killing capacity in vitro increased with the temperature and CT26 cells were more sensitive than 4T1 when heated to 43 °C. Well in line with the in vitro data, such heating cured non-metastatic CT26 tumors in vivo, while only inhibiting metastatic 4T1 tumor growth without improving the overall survival. High-temperature MHT (>47 °C) resulted in complete 4T1 primary tumor clearance, 25-40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction. Thus, the specific MHT temperature must be defined for each tumor individually to ensure a successful antitumor therapy.
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1 publication, 1.96%
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1 publication, 1.96%
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1 publication, 1.96%
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6
8
10
12
14
16
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Garanina A. S. et al. Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination // Nanomedicine: Nanotechnology, Biology, and Medicine. 2020. Vol. 25. p. 102171.
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Garanina A. S., Naumenko V., Nikitin A. A., Myrovali E., Petukhova A. Y., Klimyuk S. V., Nalench Y. A., Ilyasov A. R., Vodopyanov S. S., Erofeev A. V., Gorelkin P., Angelakeris M., Savchenko A. G., Wiedwald U., Majouga A. G., Abakumov M. A. Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination // Nanomedicine: Nanotechnology, Biology, and Medicine. 2020. Vol. 25. p. 102171.
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TY - JOUR
DO - 10.1016/j.nano.2020.102171
UR - https://doi.org/10.1016%2Fj.nano.2020.102171
TI - Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination
T2 - Nanomedicine: Nanotechnology, Biology, and Medicine
AU - Garanina, A. S.
AU - Naumenko, Victor
AU - Nikitin, Alexey A.
AU - Myrovali, E
AU - Petukhova, Anna Y
AU - Klimyuk, Svetlana V
AU - Nalench, Yulia A
AU - Ilyasov, Artem R
AU - Vodopyanov, Stepan S
AU - Erofeev, Alexander V.
AU - Gorelkin, Peter
AU - Angelakeris, Mavroeidis
AU - Savchenko, Alexander G.
AU - Wiedwald, U.
AU - Majouga, Alexander G.
AU - Abakumov, Maxim A.
PY - 2020
DA - 2020/04/01 00:00:00
PB - Elsevier
SP - 102171
VL - 25
SN - 1549-9634
SN - 1549-9642
ER -
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@article{2020_Garanina
author = {A. S. Garanina and Victor Naumenko and Alexey A. Nikitin and E Myrovali and Anna Y Petukhova and Svetlana V Klimyuk and Yulia A Nalench and Artem R Ilyasov and Stepan S Vodopyanov and Alexander V. Erofeev and Peter Gorelkin and Mavroeidis Angelakeris and Alexander G. Savchenko and U. Wiedwald and Alexander G. Majouga and Maxim A. Abakumov},
title = {Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination},
journal = {Nanomedicine: Nanotechnology, Biology, and Medicine},
year = {2020},
volume = {25},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.nano.2020.102171},
pages = {102171},
doi = {10.1016/j.nano.2020.102171}
}