Nanomedicine: Nanotechnology, Biology, and Medicine, volume 32, pages 102317
Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles
Naumenko Victor A
,
Abakumov Maxim A.
,
Muslimov Albert R.
1
,
Erofeev Alexander S.
,
Vaneev Alexander N
,
Timin Alexander S
,
Kiseleva Elena
,
Minin Artem S
,
Brikunova Olga Ya
4
,
Murzakaev Aidar M
5, 6
,
Malkeyeva Dina
,
Vtorushin Sergey V
,
Ogorodova Ludmila M
,
Gorelkin Peter V
,
Nizamov Timur R
,
Larionova Irina V
,
Gereng Elena A
4
,
Vaneev Alexander N.
8, 9
,
Naumenko Victor
9, 10
,
Erofeev Alexander V.
8, 9
,
Gorelkin Peter
9, 11
,
Nizamov Timur R.
7
,
Malkeyeva Dina
12
,
Kiseleva Elena
12
,
Vtorushin Sergey V.
13, 14
,
Larionova Irina
15, 16
,
Minin A.S.
17
,
Ogorodova Ludmila M
4
3
Nauchnaya laboratoriya meditsinskoy khimii i perspektivnykh organicheskikh materialov
11
Medical Nanotechnology LLC, Skolkovo Innovation Center Bolshoy boulevard, 42/1, Moscow, 121205, Russia.
|
Publication type: Journal Article
Publication date: 2021-02-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 15499634, 15499642
Medicine (miscellaneous)
Pharmaceutical Science
Molecular Medicine
General Materials Science
Bioengineering
Biomedical Engineering
Abstract
Acidification of the extracellular matrix, an intrinsic characteristic of many solid tumors, is widely exploited for physiologically triggered delivery of contrast agents, drugs, and nanoparticles to tumor. However, pH of tumor microenvironment shows intra- and inter-tumor variation. Herein, we investigate the impact of this variation on pH-triggered delivery of magnetic nanoparticles (MNPs) modified with pH-(low)-insertion peptide (pHLIP). Fluorescent flow cytometry, laser confocal scanning microscopy and transmission electron microscopy data proved that pHLIP-conjugated MNPs interacted with 4T1 cells in two-dimensional culture and in spheroids more effectively at pH 6.4 than at pH 7.2, and entered the cell via clathrin-independent endocytosis. The accumulation efficiency of pHLIP-conjugated MNPs in 4T1 tumors after their intravenous injection, monitored in vivo by magnetic resonance imaging, showed variation. Analysis of the tumor pH profiles recorded with implementation of original nanoprobe pH sensor, revealed obvious correlation between pH measured in the tumor with the amount of accumulated MNPs.
Citations by journals
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4
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Russian Chemical Bulletin
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Russian Chemical Bulletin
4 publications, 25%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 12.5%
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Bioprinting
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Bioprinting
1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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Drug Delivery and Translational Research
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1 publication, 6.25%
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Molecules
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Molecules
1 publication, 6.25%
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Molecular Pharmaceutics
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Molecular Pharmaceutics
1 publication, 6.25%
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Journal of Volgograd State Medical University
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Journal of Volgograd State Medical University
1 publication, 6.25%
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Biomaterials Science
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Biomaterials Science
1 publication, 6.25%
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Frontiers in Pharmacology
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Frontiers in Pharmacology
1 publication, 6.25%
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4
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Citations by publishers
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1
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5
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Springer Nature
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Springer Nature
5 publications, 31.25%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 31.25%
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Elsevier
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Elsevier
1 publication, 6.25%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 6.25%
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Volgograd State Medical University
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Volgograd State Medical University
1 publication, 6.25%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 6.25%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 6.25%
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Pershina A. G. et al. Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles // Nanomedicine: Nanotechnology, Biology, and Medicine. 2021. Vol. 32. p. 102317.
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Brikunova O. Ya., Majouga A. G., Timin A. S., Erofeev A. S., Ogorodova L. M., Krasnov V. P., Murzakaev A. M., Minin A. S., Gereng E. A., Larionova I. V., Vtorushin S. V., Malkeyeva D., Muslimov A. R., Nizamov T. R., Gorelkin P. V., Naumenko V. A., Vaneev A. N., Abakumov M. A., Demin A. V., Pershina A. G., Kiseleva E., Abakumov M. A., Vaneev A. N., Naumenko V., Erofeev A. V., Gorelkin P., Nizamov T. R., Timin A. S., Malkeyeva D., Kiseleva E., Vtorushin S. V., Larionova I., Minin A., Ogorodova L. M. Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles // Nanomedicine: Nanotechnology, Biology, and Medicine. 2021. Vol. 32. p. 102317.
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TY - JOUR
DO - 10.1016/j.nano.2020.102317
UR - https://doi.org/10.1016%2Fj.nano.2020.102317
TI - Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles
T2 - Nanomedicine: Nanotechnology, Biology, and Medicine
AU - Pershina, Alexandra G.
AU - Brikunova, Olga Ya
AU - Demin, Alexander V.
AU - Abakumov, Maxim A.
AU - Vaneev, Alexander N
AU - Naumenko, Victor A
AU - Gorelkin, Peter V
AU - Nizamov, Timur R
AU - Muslimov, Albert R.
AU - Malkeyeva, Dina
AU - Kiseleva, Elena
AU - Vtorushin, Sergey V
AU - Larionova, Irina V
AU - Gereng, Elena A
AU - Minin, Artem S
AU - Murzakaev, Aidar M
AU - Krasnov, Victor P.
AU - Ogorodova, Ludmila M
AU - Erofeev, Alexander S.
AU - Timin, Alexander S
AU - Majouga, Alexander G.
AU - Abakumov, Maxim A.
AU - Vaneev, Alexander N.
AU - Naumenko, Victor
AU - Erofeev, Alexander V.
AU - Gorelkin, Peter
AU - Nizamov, Timur R.
AU - Timin, Alexander S.
AU - Malkeyeva, Dina
AU - Kiseleva, Elena
AU - Vtorushin, Sergey V.
AU - Larionova, Irina
AU - Minin, A.S.
AU - Ogorodova, Ludmila M
PY - 2021
DA - 2021/02/01 00:00:00
PB - Elsevier
SP - 102317
VL - 32
SN - 1549-9634
SN - 1549-9642
ER -
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@article{2021_Pershina,
author = {Alexandra G. Pershina and Olga Ya Brikunova and Alexander V. Demin and Maxim A. Abakumov and Alexander N Vaneev and Victor A Naumenko and Peter V Gorelkin and Timur R Nizamov and Albert R. Muslimov and Dina Malkeyeva and Elena Kiseleva and Sergey V Vtorushin and Irina V Larionova and Elena A Gereng and Artem S Minin and Aidar M Murzakaev and Victor P. Krasnov and Ludmila M Ogorodova and Alexander S. Erofeev and Alexander S Timin and Alexander G. Majouga and Maxim A. Abakumov and Alexander N. Vaneev and Victor Naumenko and Alexander V. Erofeev and Peter Gorelkin and Timur R. Nizamov and Alexander S. Timin and Dina Malkeyeva and Elena Kiseleva and Sergey V. Vtorushin and Irina Larionova and A.S. Minin and Ludmila M Ogorodova},
title = {Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles},
journal = {Nanomedicine: Nanotechnology, Biology, and Medicine},
year = {2021},
volume = {32},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.nano.2020.102317},
pages = {102317},
doi = {10.1016/j.nano.2020.102317}
}