Progress in Biophysics and Molecular Biology, volume 147, pages 62-76

Plugged into the Ku-DNA hub: The NHEJ network.

Frit Philippe ^{1, 2}

Ropars Virginie ³

Modesti Mauro ^{4, 5}

Charbonnier J.-B. ³

Calsou Patrick ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Institut de Pharmacologie Et Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France |

Equipe Labellisée Ligue Contre le Cancer, Toulouse, France. |

Institute for Integrative Biology of the Cell (I2BC), Institute Joliot, CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette Cedex, France. |

⁴

Cancer Research Center of Marseille, CNRS UMR7258, INSERM U1068, Institut Paoli-Calmettes, Aix-Marseille Université UM105, Marseille, France |

⁵

Equipe Labellisée Ligue Contre le Cancer, Marseille, France. |

Publication type: Journal Article

Publication date: 2019-10-01

Elsevier

Journal: Progress in Biophysics and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor: 3.8

ISSN: 00796107, 18731732

DOI: 10.1016/j.pbiomolbio.2019.03.001

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Molecular Biology

Biophysics

Abstract

In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken DNA ends forming a recruiting hub. Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on proteins directly interacting with Ku and on the contact points involved, with a particular accent on the different classes of Ku-binding motifs identified in several Ku partners. An integrated structural model of the core NHEJ network at the synapsis step is proposed.

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Citations by journals

	1 2 3 4 5
Nucleic Acids Research	Nucleic Acids Research, 5, 8.33% Nucleic Acids Research 5 publications, 8.33%
Progress in Biophysics and Molecular Biology	Progress in Biophysics and Molecular Biology, 4, 6.67% Progress in Biophysics and Molecular Biology 4 publications, 6.67%
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Biochemical Society Transactions	Biochemical Society Transactions, 2, 3.33% Biochemical Society Transactions 2 publications, 3.33%
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Nature Communications	Nature Communications, 1, 1.67% Nature Communications 1 publication, 1.67%
PLoS Genetics	PLoS Genetics, 1, 1.67% PLoS Genetics 1 publication, 1.67%
Cells	Cells, 1, 1.67% Cells 1 publication, 1.67%
Journal of Biological Chemistry	Journal of Biological Chemistry, 1, 1.67% Journal of Biological Chemistry 1 publication, 1.67%
Cell Reports	Cell Reports, 1, 1.67% Cell Reports 1 publication, 1.67%
Trends in Biochemical Sciences	Trends in Biochemical Sciences, 1, 1.67% Trends in Biochemical Sciences 1 publication, 1.67%
FEBS Journal	FEBS Journal, 1, 1.67% FEBS Journal 1 publication, 1.67%
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Molecular genetics & genomic medicine	Molecular genetics & genomic medicine, 1, 1.67% Molecular genetics & genomic medicine 1 publication, 1.67%
ACS Nano	ACS Nano, 1, 1.67% ACS Nano 1 publication, 1.67%
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Applied and Environmental Microbiology	Applied and Environmental Microbiology, 1, 1.67% Applied and Environmental Microbiology 1 publication, 1.67%
Methods in Molecular Biology	Methods in Molecular Biology, 1, 1.67% Methods in Molecular Biology 1 publication, 1.67%
Annual Review of Biochemistry	Annual Review of Biochemistry, 1, 1.67% Annual Review of Biochemistry 1 publication, 1.67%
Science advances	Science advances, 1, 1.67% Science advances 1 publication, 1.67%
	1 2 3 4 5

Citations by publishers

	2 4 6 8 10 12
Elsevier	Elsevier, 11, 18.33% Elsevier 11 publications, 18.33%
Springer Nature	Springer Nature, 6, 10% Springer Nature 6 publications, 10%
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Oxford University Press	Oxford University Press, 5, 8.33% Oxford University Press 5 publications, 8.33%
Frontiers Media S.A.	Frontiers Media S.A., 4, 6.67% Frontiers Media S.A. 4 publications, 6.67%
Wiley	Wiley, 3, 5% Wiley 3 publications, 5%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 5% American Chemical Society (ACS) 3 publications, 5%
eLife Sciences Publications	eLife Sciences Publications, 2, 3.33% eLife Sciences Publications 2 publications, 3.33%
Portland Press	Portland Press, 2, 3.33% Portland Press 2 publications, 3.33%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.67% Public Library of Science (PLoS) 1 publication, 1.67%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.67% American Society for Biochemistry and Molecular Biology 1 publication, 1.67%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 1.67% Royal Society of Chemistry (RSC) 1 publication, 1.67%
Taylor & Francis	Taylor & Francis, 1, 1.67% Taylor & Francis 1 publication, 1.67%
American Society for Microbiology	American Society for Microbiology, 1, 1.67% American Society for Microbiology 1 publication, 1.67%
Annual Reviews	Annual Reviews, 1, 1.67% Annual Reviews 1 publication, 1.67%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 1.67% American Association for the Advancement of Science (AAAS) 1 publication, 1.67%
	2 4 6 8 10 12

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Frit P. et al. Plugged into the Ku-DNA hub: The NHEJ network. // Progress in Biophysics and Molecular Biology. 2019. Vol. 147. pp. 62-76.

GOST all authors (up to 50) Copy

Frit P., Ropars V., Modesti M., Charbonnier J., Calsou P. Plugged into the Ku-DNA hub: The NHEJ network. // Progress in Biophysics and Molecular Biology. 2019. Vol. 147. pp. 62-76.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.pbiomolbio.2019.03.001

UR - https://doi.org/10.1016%2Fj.pbiomolbio.2019.03.001

TI - Plugged into the Ku-DNA hub: The NHEJ network.

T2 - Progress in Biophysics and Molecular Biology

AU - Frit, Philippe

AU - Ropars, Virginie

AU - Modesti, Mauro

AU - Charbonnier, J.-B.

AU - Calsou, Patrick

PY - 2019

DA - 2019/10/01 00:00:00

PB - Elsevier

SP - 62-76

VL - 147

SN - 0079-6107

SN - 1873-1732

ER -

BibTex

Cite this

BibTex Copy

@article{2019_Frit,

author = {Philippe Frit and Virginie Ropars and Mauro Modesti and J.-B. Charbonnier and Patrick Calsou},

title = {Plugged into the Ku-DNA hub: The NHEJ network.},

journal = {Progress in Biophysics and Molecular Biology},

year = {2019},

volume = {147},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016%2Fj.pbiomolbio.2019.03.001},

pages = {62--76},

doi = {10.1016/j.pbiomolbio.2019.03.001}

}

Found error?

Publisher

Elsevier

Journal

Progress in Biophysics and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor

3.8

ISSN

00796107 (Print)
18731732 (Electronic)