Elsevier
Progress in Biophysics and Molecular Biology
,  том 159 ,  страницы 34-45

The role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscle

Тип публикации: Journal Article
Дата публикации: 2021-01-01
Elsevier
scimago Q1
wos Q1
БС1
SJR: 1.141
CiteScore: 9.2
Impact factor: 4.5
ISSN: 00796107, 18731732
Molecular Biology
Biophysics
Краткое описание
Myocardial function is tuned by dynamic changes in length and load via mechano-calcium feedback. This regulation may be significantly affected by heart rhythm. We evaluated the mechano-induced modulation of contractility and Ca-transient (CaT) in the rat myocardium subjected to twitch-by-twitch shortening–re-lengthening (↓–↑) trains of different lengths (N = 1 … 720 cycles) at low (1 Hz) and near-physiological (3.5 Hz) pacing rates. Force/CaT characteristics were evaluated in the first post-train isometric twitch (immediate effect) and during slow changes (delayed maximal elevation/decrease) and compared with those of the pre-train twitch. The immediate inotropic effect was positive for N = 30 … 720 and negative for N = 1 … 20, while the delayed effect was always positive. The immediate and delayed inotropic effects were significantly higher at 3.5-Hz vs 1-Hz (P
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Lookin O. et al. The role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscle // Progress in Biophysics and Molecular Biology. 2021. Vol. 159. pp. 34-45.
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Lookin O., Protsenko Y. The role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscle // Progress in Biophysics and Molecular Biology. 2021. Vol. 159. pp. 34-45.
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TY - JOUR
DO - 10.1016/j.pbiomolbio.2020.05.005
UR - https://doi.org/10.1016/j.pbiomolbio.2020.05.005
TI - The role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscle
T2 - Progress in Biophysics and Molecular Biology
AU - Lookin, Oleg
AU - Protsenko, Yuri
PY - 2021
DA - 2021/01/01
PB - Elsevier
SP - 34-45
VL - 159
PMID - 32450183
SN - 0079-6107
SN - 1873-1732
ER -
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@article{2021_Lookin,
author = {Oleg Lookin and Yuri Protsenko},
title = {The role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscle},
journal = {Progress in Biophysics and Molecular Biology},
year = {2021},
volume = {159},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.pbiomolbio.2020.05.005},
pages = {34--45},
doi = {10.1016/j.pbiomolbio.2020.05.005}
}