Photodiagnosis and Photodynamic Therapy, volume 31, pages 101917
Chlorin e6-mediated photodynamic therapy modulates adipocyte differentiation and lipogenesis in 3T3-L1 cells.
1
Department of Medical Biotechnology, Soonchunhyang University, 22 Soonchunhyang-ro, Asan-si, 31538, Republic of Korea
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2
Daegu Cancer Center, Research and Development Unit, DongSung Bio-Pharmaceuticals Co. Ltd., 8, Cheombok-ro, Daegu-si, 41061, Republic of Korea.
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Publication type: Journal Article
Publication date: 2020-09-01
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.3
ISSN: 15721000
Oncology
Biophysics
Pharmacology (medical)
Dermatology
Abstract
BACKGROUND
Chlorin e6-mediated photodynamic therapy (Ce6-mediated PDT) is a therapeutic modality that consists of a photosensitizer, source of light at a suitable wavelength, and molecular oxygen. PDT has been widely used for the treatment of cancers and non-neoplastic disorders. However, information on the inhibitory activity of Ce6-mediated PDT on adipogenesis and lipogenesis in 3T3-L1 cells is not available to date.
METHODS
MTT assay, Oil Red O staining, and Nile red staining were used to investigate lipid accumulation in 3T3-L1 cells to clarify adipocyte differentiation. The expression levels of various molecular signals associated with adipogenesis and lipogenesis were examined by RT-PCR and western blot analysis.
RESULTS
Adipocyte differentiation and lipid accumulation were reduced by Ce6-mediated PDT in 3T3-L1 cells. Inhibition of the expression of PPAR-γ, C/EBPα, β, δ, SREBP-1, FAS, and LPL and the activation of AMPK, revealed concise modulation of adipogenic and lipogenic molecules by Ce6-mediated PDT. The anti-adipogenic effect of Ce6-mediated PDT was reversed by AMPKα siRNA.
CONCLUSION
Ce6-mediated PDT inhibits adipocyte differentiation and lipogenesis via regulating AMPK. Ce6-mediated PDT can serve as an effective potential therapy for the treatment of obesity and obesity-associated diseases.
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1 publication, 11.11%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ryu A. R., Kim Y., Lee M. Chlorin e6-mediated photodynamic therapy modulates adipocyte differentiation and lipogenesis in 3T3-L1 cells. // Photodiagnosis and Photodynamic Therapy. 2020. Vol. 31. p. 101917.
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Ryu A. R., Kim Y., Lee M. Chlorin e6-mediated photodynamic therapy modulates adipocyte differentiation and lipogenesis in 3T3-L1 cells. // Photodiagnosis and Photodynamic Therapy. 2020. Vol. 31. p. 101917.
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TY - JOUR
DO - 10.1016/j.pdpdt.2020.101917
UR - https://doi.org/10.1016%2Fj.pdpdt.2020.101917
TI - Chlorin e6-mediated photodynamic therapy modulates adipocyte differentiation and lipogenesis in 3T3-L1 cells.
T2 - Photodiagnosis and Photodynamic Therapy
AU - Ryu, A Reum
AU - Kim, Yong-Wan
AU - Lee, Miyoung
PY - 2020
DA - 2020/09/01 00:00:00
PB - Elsevier
SP - 101917
VL - 31
SN - 1572-1000
ER -
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@article{2020_Ryu,
author = {A Reum Ryu and Yong-Wan Kim and Miyoung Lee},
title = {Chlorin e6-mediated photodynamic therapy modulates adipocyte differentiation and lipogenesis in 3T3-L1 cells.},
journal = {Photodiagnosis and Photodynamic Therapy},
year = {2020},
volume = {31},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.pdpdt.2020.101917},
pages = {101917},
doi = {10.1016/j.pdpdt.2020.101917}
}