Polyhedron, volume 105, pages 12-17
A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells
Liu Si-Hong
1
,
Xu Hui-Hua
1
,
Zhu Jianwei
1
,
Wang Yan
1
,
Liu Ya-Min
1
,
Liang Junbo
1
,
Zhang Guiqiang
1
,
Cao Di Hua
2
,
Lin Yang-Yang
2
,
Guo Qifeng
1
,
Wu Yong
3
Publication type: Journal Article
Publication date: 2016-02-01
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
A new Ru(II) complex, [Ru(ttbpy) 2 (NMIP)](ClO 4 ) 2 (ttbpy = 4,4′-di-tert butyl-2,2′-bipyridine, NMIP = 2′-(2″-nitro-3″,4″-methylenedioxyphenyl)imidazo[4′,5′- f ][1,10]-phenanthroline), has been synthesized and characterized by elemental analysis, ESI-MS and 1 H NMR spectroscopy. The complex induces a decrease in fluorescent intensity upon binding to protein bovine serum albumin (BSA). The cytotoxic activity of the ligand and the complex against A549, BEL-7402, HeLa, PC-12, SGC-7901, SiHa and LO2 (normal) cell lines was investigated by the MTT method. The complex show high cytotoxicity toward BEL-7402 (IC 50 = 5.0 ± 1.2 μM), HeLa (IC 50 = 5.7 ± 1.8 μM) and SGC-7901 (IC 50 = 4.9 ± 0.2 μM) cell lines. The cellular uptake indicates that the complex can enter into the cytoplasm and accumulate in the cell nuclei. In addition, the complex can increase the reactive oxygen species levels and induce a decrease in the mitochondrial membrane potential in SGC-7901 cells. The cell cycle arrest shows that the complex inhibited the cell growth in SGC-7901 cells at the G2/M phase.
Citations by journals
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1 publication, 33.33%
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Applied Organometallic Chemistry
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1 publication, 33.33%
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1
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Elsevier
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Elsevier
1 publication, 33.33%
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Wiley
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Wiley
1 publication, 33.33%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 33.33%
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1
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Liu S. et al. A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells // Polyhedron. 2016. Vol. 105. pp. 12-17.
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Liu S., Xu H., Zhu J., Wang Y., Liu Y., Liang J., Zhang G., Cao D. H., Lin Y., Guo Q., Wu Y. A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells // Polyhedron. 2016. Vol. 105. pp. 12-17.
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TY - JOUR
DO - 10.1016/j.poly.2015.11.052
UR - https://doi.org/10.1016%2Fj.poly.2015.11.052
TI - A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells
T2 - Polyhedron
AU - Liu, Si-Hong
AU - Xu, Hui-Hua
AU - Zhu, Jianwei
AU - Wang, Yan
AU - Liu, Ya-Min
AU - Liang, Junbo
AU - Zhang, Guiqiang
AU - Cao, Di Hua
AU - Lin, Yang-Yang
AU - Guo, Qifeng
AU - Wu, Yong
PY - 2016
DA - 2016/02/01 00:00:00
PB - Elsevier
SP - 12-17
VL - 105
SN - 0277-5387
ER -
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@article{2016_Liu,
author = {Si-Hong Liu and Hui-Hua Xu and Jianwei Zhu and Yan Wang and Ya-Min Liu and Junbo Liang and Guiqiang Zhang and Di Hua Cao and Yang-Yang Lin and Qifeng Guo and Yong Wu},
title = {A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells},
journal = {Polyhedron},
year = {2016},
volume = {105},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.poly.2015.11.052},
pages = {12--17},
doi = {10.1016/j.poly.2015.11.052}
}