Polyhedron, volume 107, pages 27-37

Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines

Beloglazkina Elena K. ^{1, 2}

Manzheliy Eugeniy A ³

Moiseeva Anna A. ³

Maloshitskaya Olga A ³

Zyk Nikolai V. ³

Skvortsov Dmitry ³

Osterman Ilya A ³

Sergiev Petr V. ³

Dontsova Olga A. ³

Ivanenkov Yan ^{1, 4, 5}

Veselov Mark S. ^{1, 4, 5}

Majouga Alexander G. ^{1, 2}

Hide authors affiliations Show authors affiliations: 5 affiliations

National University of Science and Technology “MISIS” (MISiS), Leninskiy Prospekt 4, 119049 Moscow, Russia |

Department of Chemistry, M.V.Lomonosov Moscow State University, Leninskie Gory, 119991 Moscow, Russia |

Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory, 119991, Moscow, Russia |

⁴

Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory, 119991 Moscow, Russia |

⁵

Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Institutski Pereulok 9, 141700 Moskovskaya Oblast, Russia |

Publication type: Journal Article

Publication date: 2016-03-01

Elsevier

Journal: Polyhedron

Quartile SCImago

Quartile WOS

Impact factor: 2.6

ISSN: 02775387

DOI: 10.1016/j.poly.2015.12.059

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Materials Chemistry

Inorganic Chemistry

Physical and Theoretical Chemistry

Abstract

Abstract The synthesis and characterisation of novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2](PF6)2, [Rh(tpy)2](PF6)3, [Ru(phen)(tpy)Cl](PF6), [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = S-[ω-(2,2:6′,2″-terpyridin-4′-yl)phenoxy]alkyl ethanethioate) have been described. Ligands and complexes were characterised by 1H NMR spectroscopy, mass spectrometry, elemental analysis and cyclic voltammetry data. The crystal structure of the complex [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = 4′-phenyl-2,2′:6′,2″-terpyridine) (21), have been determined by X-ray crystallography. Complex 21 show a distorted octahedral geometry around the ruthenium centre. Antimicrobial activity toward Escherichia coli at concentrations as low as 5 μM was found for some of the studied complexes. For complexes [Rh(tpy C6H4 O(CH2)8 SCOCH3)2](PF6)3 (19), [Rh(phen)(tpy C6H4 O (CH2)8 SCOCH3)Cl](PF6)2 (31) and [Rh(phen)(tpy C6H4 O (CH2)11 SCOCH3)Cl](PF6)2 (32), a strong inhibition of in vitro protein synthesis was observed using firefly luciferase. An investigation of cytotoxicity of the complexes against human embryonic kidney cells (HEK293 line) by the MTT assay demonstrates that the toxicity of all tested compounds is of similar magnitude, with IC50 values of 3–30 μM.

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Beloglazkina E. K. et al. Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines // Polyhedron. 2016. Vol. 107. pp. 27-37.

GOST all authors (up to 50) Copy

Beloglazkina E. K., Manzheliy E. A., Moiseeva A. A., Maloshitskaya O. A., Zyk N. V., Skvortsov D., Osterman I. A., Sergiev P. V., Dontsova O. A., Ivanenkov Y., Veselov M. S., Majouga A. G. Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines // Polyhedron. 2016. Vol. 107. pp. 27-37.

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RIS Copy

TY - JOUR

DO - 10.1016/j.poly.2015.12.059

UR - https://doi.org/10.1016%2Fj.poly.2015.12.059

TI - Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines

T2 - Polyhedron

AU - Manzheliy, Eugeniy A

AU - Moiseeva, Anna A.

AU - Maloshitskaya, Olga A

AU - Zyk, Nikolai V.

AU - Dontsova, Olga A.

AU - Ivanenkov, Yan

AU - Veselov, Mark S.

AU - Beloglazkina, Elena K.

AU - Skvortsov, Dmitry

AU - Osterman, Ilya A

AU - Sergiev, Petr V.

AU - Majouga, Alexander G.

PY - 2016

DA - 2016/03/01 00:00:00

PB - Elsevier

SP - 27-37

VL - 107

SN - 0277-5387

ER -

BibTex

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BibTex Copy

@article{2016_Beloglazkina,

author = {Eugeniy A Manzheliy and Anna A. Moiseeva and Olga A Maloshitskaya and Nikolai V. Zyk and Olga A. Dontsova and Yan Ivanenkov and Mark S. Veselov and Elena K. Beloglazkina and Dmitry Skvortsov and Ilya A Osterman and Petr V. Sergiev and Alexander G. Majouga},

title = {Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines},

journal = {Polyhedron},

year = {2016},

volume = {107},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016%2Fj.poly.2015.12.059},

pages = {27--37},

doi = {10.1016/j.poly.2015.12.059}

}

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Publisher

Elsevier

Journal

Polyhedron

Quartile SCImago

Quartile WOS

Impact factor

2.6

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02775387 (Print)

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Polyhedron	Polyhedron, 3, 18.75% Polyhedron 3 publications, 18.75%
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Pharmaceutics	Pharmaceutics, 1, 6.25% Pharmaceutics 1 publication, 6.25%
Journal of Inorganic Biochemistry	Journal of Inorganic Biochemistry, 1, 6.25% Journal of Inorganic Biochemistry 1 publication, 6.25%
International Biodeterioration and Biodegradation	International Biodeterioration and Biodegradation, 1, 6.25% International Biodeterioration and Biodegradation 1 publication, 6.25%
Advances in Microbial Physiology	Advances in Microbial Physiology, 1, 6.25% Advances in Microbial Physiology 1 publication, 6.25%
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