Polyhedron, том 107, номера страниц: 27-37

Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines

Zyk Nikolai V.
Veselov Mark S.
Maloshitskaya Olga A.
Manzheliy Eugeniy A.
Тип документаJournal Article
Дата публикации2016-03-09
Название журналаPolyhedron
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ2
Импакт-фактор 20212.98
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Краткое описание
Abstract The synthesis and characterisation of novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2](PF6)2, [Rh(tpy)2](PF6)3, [Ru(phen)(tpy)Cl](PF6), [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = S-[ω-(2,2:6′,2″-terpyridin-4′-yl)phenoxy]alkyl ethanethioate) have been described. Ligands and complexes were characterised by 1H NMR spectroscopy, mass spectrometry, elemental analysis and cyclic voltammetry data. The crystal structure of the complex [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = 4′-phenyl-2,2′:6′,2″-terpyridine) (21), have been determined by X-ray crystallography. Complex 21 show a distorted octahedral geometry around the ruthenium centre. Antimicrobial activity toward Escherichia coli at concentrations as low as 5 μM was found for some of the studied complexes. For complexes [Rh(tpy C6H4 O(CH2)8 SCOCH3)2](PF6)3 (19), [Rh(phen)(tpy C6H4 O (CH2)8 SCOCH3)Cl](PF6)2 (31) and [Rh(phen)(tpy C6H4 O (CH2)11 SCOCH3)Cl](PF6)2 (32), a strong inhibition of in vitro protein synthesis was observed using firefly luciferase. An investigation of cytotoxicity of the complexes against human embryonic kidney cells (HEK293 line) by the MTT assay demonstrates that the toxicity of all tested compounds is of similar magnitude, with IC50 values of 3–30 μM.
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1. Beloglazkina E.K. и др. Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines // Polyhedron. 2016. Т. 107. С. 27–37.


DO - 10.1016/j.poly.2015.12.059

UR - http://dx.doi.org/10.1016/j.poly.2015.12.059

TI - Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines

T2 - Polyhedron

AU - Beloglazkina, Elena K.

AU - Manzheliy, Eugeniy A.

AU - Moiseeva, Anna A.

AU - Maloshitskaya, Olga A.

AU - Zyk, Nikolai V.

AU - Skvortsov, Dmitry A.

AU - Osterman, Ilya A.

AU - Sergiev, Petr V.

AU - Dontsova, Olga A.

AU - Ivanenkov, Yan A.

AU - Veselov, Mark S.

AU - Majouga, Alexander G.

PY - 2016

DA - 2016/03

PB - Elsevier BV

SP - 27-37

VL - 107

SN - 0277-5387

ER -

BibTex |


doi = {10.1016/j.poly.2015.12.059},

url = {https://doi.org/10.1016%2Fj.poly.2015.12.059},

year = 2016,

month = {mar},

publisher = {Elsevier {BV}},

volume = {107},

pages = {27--37},

author = {Elena K. Beloglazkina and Eugeniy A. Manzheliy and Anna A. Moiseeva and Olga A. Maloshitskaya and Nikolai V. Zyk and Dmitry A. Skvortsov and Ilya A. Osterman and Petr V. Sergiev and Olga A. Dontsova and Yan A. Ivanenkov and Mark S. Veselov and Alexander G. Majouga},

title = {Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium({II}) and rhodium({III}) complexes with sulfur-containing terpyridines}


Beloglazkina, Elena K. et al. “Synthesis, Characterisation, Cytotoxicity and Antibacterial Activity of ruthenium(II) and rhodium(III) Complexes with Sulfur-Containing Terpyridines.” Polyhedron 107 (2016): 27–37. Crossref. Web.