Polyhedron, том 107, номера страниц: 27-37

Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines

Zyk Nikolai V.
Veselov Mark S.
Maloshitskaya Olga A.
Manzheliy Eugeniy A.
Тип документаJournal Article
Дата публикации2016-03-09
ИздательElsevier
Название журналаPolyhedron
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ2
Импакт-фактор 20212.98
ISSN02775387
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Краткое описание
Abstract The synthesis and characterisation of novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2](PF6)2, [Rh(tpy)2](PF6)3, [Ru(phen)(tpy)Cl](PF6), [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = S-[ω-(2,2:6′,2″-terpyridin-4′-yl)phenoxy]alkyl ethanethioate) have been described. Ligands and complexes were characterised by 1H NMR spectroscopy, mass spectrometry, elemental analysis and cyclic voltammetry data. The crystal structure of the complex [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = 4′-phenyl-2,2′:6′,2″-terpyridine) (21), have been determined by X-ray crystallography. Complex 21 show a distorted octahedral geometry around the ruthenium centre. Antimicrobial activity toward Escherichia coli at concentrations as low as 5 μM was found for some of the studied complexes. For complexes [Rh(tpy C6H4 O(CH2)8 SCOCH3)2](PF6)3 (19), [Rh(phen)(tpy C6H4 O (CH2)8 SCOCH3)Cl](PF6)2 (31) and [Rh(phen)(tpy C6H4 O (CH2)11 SCOCH3)Cl](PF6)2 (32), a strong inhibition of in vitro protein synthesis was observed using firefly luciferase. An investigation of cytotoxicity of the complexes against human embryonic kidney cells (HEK293 line) by the MTT assay demonstrates that the toxicity of all tested compounds is of similar magnitude, with IC50 values of 3–30 μM.
Пристатейные ссылки: 109
Цитируется в публикациях: 9
A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells
Liu S., Xu H., Zhu J., Wang Y., Liu Y., Liang J., Zhang G., Cao D., Lin Y., Guo Q., Wu Y.
Q2 Polyhedron 2016 цитирований: 2
Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs
Furrer J., Süss-Fink G.
Q1 Coordination Chemistry Reviews 2016 цитирований: 83
Synthesis, Anticancer Activity, and Genome Profiling of Thiazolo Arene Ruthenium Complexes
Grozav A., Balacescu O., Balacescu L., Cheminel T., Berindan-Neagoe I., Therrien B.
Q1 Journal of Medicinal Chemistry 2015 цитирований: 44
Open Access
Open access
Synthesis, Structure, DNA/Protein Binding, and Anticancer Activity of Some Half-Sandwich Cyclometalated Rh(III) and Ir(III) Complexes
Mukhopadhyay S., Gupta R.K., Paitandi R.P., Rana N.K., Sharma G., Koch B., Rana L.K., Hundal M.S., Pandey D.S.
Q1 Organometallics 2015 цитирований: 97
Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells
Zhou Y., Yu Q., Qin X., Bhavsar D., Yang L., Chen Q., Zheng W., Chen L., Liu J.
Q1 ACS applied materials & interfaces 2015 цитирований: 38
Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome
Polikanov Y., Osterman I., Szal T., Tashlitsky V., Serebryakova M., Kusochek P., Bulkley D., Malanicheva I., Efimenko T., Efremenkova O., Konevega A., Shaw K., Bogdanov A., Rodnina M., Dontsova O., et. al.
Q1 Molecular Cell 2014 цитирований: 62
Open Access
Open access
Applications of five-membered ring products of cyclometalation reactions as anticancer agents
Omae I.
Q1 Coordination Chemistry Reviews 2014 цитирований: 85
Group 9 Organometallic Compounds for Therapeutic and Bioanalytical Applications
Ma D., Chan D.S., Leung C.
Q1 Accounts of Chemical Research 2014 цитирований: 205
Derivation of Structure–Activity Relationships from the Anticancer Properties of Ruthenium(II) Arene Complexes with 2-Aryldiazole Ligands
Martínez-Alonso M., Busto N., Jalón F.A., Manzano B.R., Leal J.M., Rodríguez A.M., García B., Espino G.
Q1 Inorganic Chemistry 2014 цитирований: 69
Structural features and cytotoxic activities of [Ru(AA-H)(dppb)(bipy)]PF6 complexes
Almeida M.A., do Nascimento F.B., Graminha A.E., Ferreira A.G., Ellena J., Mello F.M., de Lima A.P., Silveira-Lacerda E.D., Batista A.A.
Q2 Polyhedron 2014 цитирований: 15
Interaction of ferrocene appended Ru(II), Rh(III) and Ir(III) dipyrrinato complexes with DNA/protein, molecular docking and antitumor activity
Paitandi R.P., Gupta R.K., Singh R.S., Sharma G., Koch B., Pandey D.S.
Q1 European Journal of Medicinal Chemistry 2014 цитирований: 63
Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity
Majouga A.G., Zvereva M.I., Rubtsova M.P., Skvortsov D.A., Mironov A.V., Azhibek D.M., Krasnovskaya O.O., Gerasimov V.M., Udina A.V., Vorozhtsov N.I., Beloglazkina E.K., Agron L., Mikhina L.V., Tretyakova A.V., Zyk N.V., et. al.
Q1 Journal of Medicinal Chemistry 2014 цитирований: 59
Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes
Peña B., David A., Pavani C., Baptista M.S., Pellois J., Turro C., Dunbar K.R.
Q1 Organometallics 2014 цитирований: 90
Structural, electronic and acid/base properties of [Ru(tpy)(tpyOH)]2+ and [Ru(tpyOH)2]2+ (tpy=2,2′:6′,2″-terpyridine, tpyOH=4′-hydroxy-2,2′:6′,2″-terpyridine)
Maghacut K.A., Wood A.B., Boyko W.J., Dudley T.J., Paul J.J.
Q2 Polyhedron 2014 цитирований: 11
Метрики

Поделиться

Цитировать
ГОСТ |
Цитировать
1. Beloglazkina E.K. и др. Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines // Polyhedron. 2016. Т. 107. С. 27–37.
RIS |
Цитировать

TY - JOUR

DO - 10.1016/j.poly.2015.12.059

UR - http://dx.doi.org/10.1016/j.poly.2015.12.059

TI - Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines

T2 - Polyhedron

AU - Beloglazkina, Elena K.

AU - Manzheliy, Eugeniy A.

AU - Moiseeva, Anna A.

AU - Maloshitskaya, Olga A.

AU - Zyk, Nikolai V.

AU - Skvortsov, Dmitry A.

AU - Osterman, Ilya A.

AU - Sergiev, Petr V.

AU - Dontsova, Olga A.

AU - Ivanenkov, Yan A.

AU - Veselov, Mark S.

AU - Majouga, Alexander G.

PY - 2016

DA - 2016/03

PB - Elsevier BV

SP - 27-37

VL - 107

SN - 0277-5387

ER -

BibTex |
Цитировать

@article{2016,

doi = {10.1016/j.poly.2015.12.059},

url = {https://doi.org/10.1016%2Fj.poly.2015.12.059},

year = 2016,

month = {mar},

publisher = {Elsevier {BV}},

volume = {107},

pages = {27--37},

author = {Elena K. Beloglazkina and Eugeniy A. Manzheliy and Anna A. Moiseeva and Olga A. Maloshitskaya and Nikolai V. Zyk and Dmitry A. Skvortsov and Ilya A. Osterman and Petr V. Sergiev and Olga A. Dontsova and Yan A. Ivanenkov and Mark S. Veselov and Alexander G. Majouga},

title = {Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium({II}) and rhodium({III}) complexes with sulfur-containing terpyridines}

}

MLA
Цитировать
Beloglazkina, Elena K. et al. “Synthesis, Characterisation, Cytotoxicity and Antibacterial Activity of ruthenium(II) and rhodium(III) Complexes with Sulfur-Containing Terpyridines.” Polyhedron 107 (2016): 27–37. Crossref. Web.