Radiation Physics and Chemistry, volume 193, pages 109998
On the mechanism of radiation sensitization by gold nanoparticles under X-ray irradiation of oxygen-free aqueous organic solutions: A spin trapping study
Dementeva Olga V
2
,
Kartseva Maria E
2
,
Shishmakova Elena M
2
,
Baranova Irina
1
,
Rudoy Victor.M.
2
,
Publication type: Journal Article
Publication date: 2022-04-01
Journal:
Radiation Physics and Chemistry
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 2.9
ISSN: 0969806X
Radiation
Abstract
In this study we have probed the role of different enhancement mechanisms of the nanosensitizers in the X-ray irradiated oxygen-free model aqueous organic systems containing “bare” gold nanoparticles (AuNPs) using the spin-trapping technique with electron paramagnetic resonance detection. The observed enhancement effect was found to be ca. 1.67 wp −1 for the AuNPs with an average diameter of 18 nm and 45 kVp X-rays. The comparison with Monte Carlo simulation shows that the sensitizing effect of AuNPs in the X-ray irradiated oxygen-free aqueous organic systems could be attributed to the increasing absorbed dose due to high absorption cross-section of gold atoms. It implies that the radiation-chemical yield of hydroxyl radicals responsible for the oxidative damage in the absence of oxygen remains virtually unchanged in the presence of AuNPs. Also, no clear evidence was found for the dose rate effects upon variation of this parameter by more than an order of magnitude (0.06–1.21 Gy/s). In practical sense, these results urge the development of new efficient approaches for the radiation treatment of hypoxic media using nanoparticles. • The sensitizing effect of gold NPs under X-ray irradiation in oxygen-free environment was studied. • The effect is reasonably explained by the physical enhancement mechanism. • The experimental results are in agreement with the Monte Carlo simulations. • No evidence for chemical enhancement was found under the hypoxic conditions.
Citations by journals
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Particle and Particle Systems Characterization
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Pharmaceutics
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Citations by publishers
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1
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Wiley
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Wiley
1 publication, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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1
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Shiryaeva E. S. et al. On the mechanism of radiation sensitization by gold nanoparticles under X-ray irradiation of oxygen-free aqueous organic solutions: A spin trapping study // Radiation Physics and Chemistry. 2022. Vol. 193. p. 109998.
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Shiryaeva E. S., Baranova I. A., Sanochkina E. V., Dementeva O. V., Kartseva M. E., Shishmakova E. M., Belousov A. V., Morozov V. N., Feldman V. I., Baranova I., Rudoy V., Morozov V. A. On the mechanism of radiation sensitization by gold nanoparticles under X-ray irradiation of oxygen-free aqueous organic solutions: A spin trapping study // Radiation Physics and Chemistry. 2022. Vol. 193. p. 109998.
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TY - JOUR
DO - 10.1016/j.radphyschem.2022.109998
UR - https://doi.org/10.1016%2Fj.radphyschem.2022.109998
TI - On the mechanism of radiation sensitization by gold nanoparticles under X-ray irradiation of oxygen-free aqueous organic solutions: A spin trapping study
T2 - Radiation Physics and Chemistry
AU - Shiryaeva, Ekaterina S
AU - Baranova, Irina A
AU - Sanochkina, Elizaveta V
AU - Dementeva, Olga V
AU - Kartseva, Maria E
AU - Shishmakova, Elena M
AU - Belousov, Alexandr V
AU - Morozov, Vladimir N
AU - Feldman, Vladimir I.
AU - Baranova, Irina
AU - Rudoy, Victor.M.
AU - Morozov, Vladimir Alexei
PY - 2022
DA - 2022/04/01 00:00:00
PB - Elsevier
SP - 109998
VL - 193
SN - 0969-806X
ER -
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@article{2022_Shiryaeva,
author = {Ekaterina S Shiryaeva and Irina A Baranova and Elizaveta V Sanochkina and Olga V Dementeva and Maria E Kartseva and Elena M Shishmakova and Alexandr V Belousov and Vladimir N Morozov and Vladimir I. Feldman and Irina Baranova and Victor.M. Rudoy and Vladimir Alexei Morozov},
title = {On the mechanism of radiation sensitization by gold nanoparticles under X-ray irradiation of oxygen-free aqueous organic solutions: A spin trapping study},
journal = {Radiation Physics and Chemistry},
year = {2022},
volume = {193},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.radphyschem.2022.109998},
pages = {109998},
doi = {10.1016/j.radphyschem.2022.109998}
}