Open Access
Current Opinion in Structural Biology, volume 53, pages 187-198
PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification
1
Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec, Canada
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Publication type: Journal Article
Publication date: 2018-12-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.8
ISSN: 0959440X, 1879033X
PubMed ID:
30481609
Molecular Biology
Structural Biology
Abstract
Poly(ADP-ribose) is a posttranslational modification and signaling molecule that regulates many aspects of human cell biology, and it is synthesized by enzymes known as poly(ADP-ribose) polymerases, or PARPs. A diverse collection of domain structures dictates the different cellular roles of PARP enzymes and regulates the production of poly(ADP-ribose). Here we primarily review recent structural insights into the regulation and catalysis of two family members: PARP-1 and Tankyrase. PARP-1 has multiple roles in the cellular response to DNA damage and the regulation of gene transcription, and Tankyrase regulates a diverse set of target proteins involved in cellular processes such as mitosis, genome integrity, and cell signaling. Both enzymes offer interesting modes of regulating the production and the target site selectivity of the poly(ADP-ribose) modification.
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- We do not take into account publications that without a DOI.
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Langelier M. et al. PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification // Current Opinion in Structural Biology. 2018. Vol. 53. pp. 187-198.
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Langelier M., Eisemann T., Riccio A. A., Pascal J. M. PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification // Current Opinion in Structural Biology. 2018. Vol. 53. pp. 187-198.
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TY - JOUR
DO - 10.1016/j.sbi.2018.11.002
UR - https://doi.org/10.1016%2Fj.sbi.2018.11.002
TI - PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification
T2 - Current Opinion in Structural Biology
AU - Langelier, Marie-France
AU - Eisemann, Travis
AU - Riccio, Amanda A
AU - Pascal, John M.
PY - 2018
DA - 2018/12/01 00:00:00
PB - Elsevier
SP - 187-198
VL - 53
PMID - 30481609
SN - 0959-440X
SN - 1879-033X
ER -
Cite this
BibTex
Copy
@article{2018_Langelier,
author = {Marie-France Langelier and Travis Eisemann and Amanda A Riccio and John M. Pascal},
title = {PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification},
journal = {Current Opinion in Structural Biology},
year = {2018},
volume = {53},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.sbi.2018.11.002},
pages = {187--198},
doi = {10.1016/j.sbi.2018.11.002}
}