Seminars in Cell and Developmental Biology, volume 113, pages 88-96

Alternative paths to telomere elongation.

Lee Jennifer D 1
LEE JUN-YEOP 1
Lee Hyun-Sook 1
1
 
Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 08832, South Korea.
Publication typeJournal Article
Publication date2021-05-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor7.3
ISSN10849521, 10963634
Cell Biology
Developmental Biology
Abstract
Overcoming cellular senescence that is induced by telomere shortening is critical in tumorigenesis. A majority of cancers achieve telomere maintenance through telomerase expression. However, a subset of cancers takes an alternate route for elongating telomeres: recombination-based alternative lengthening of telomeres (ALT). Current evidence suggests that break-induced replication (BIR), independent of RAD51, underlies ALT telomere synthesis. However, RAD51-dependent homologous recombination is required for homology search and inter-chromosomal telomere recombination in human ALT cancer cell maintenance. Accumulating evidence suggests that the breakdown of stalled replication forks, the replication stress, induces BIR at telomeres. Nevertheless, ALT research is still in its early stage and a comprehensive view is still unclear. Here, we review the current findings regarding the genesis of ALT, how this recombinant pathway is chosen, the epigenetic regulation of telomeres in ALT, and perspectives for clinical applications with the hope that this overview will generate new questions.

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Lee J. D., LEE J., Lee H. Alternative paths to telomere elongation. // Seminars in Cell and Developmental Biology. 2021. Vol. 113. pp. 88-96.
GOST all authors (up to 50) Copy
Lee J. D., LEE J., Lee H. Alternative paths to telomere elongation. // Seminars in Cell and Developmental Biology. 2021. Vol. 113. pp. 88-96.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.semcdb.2020.11.003
UR - https://doi.org/10.1016%2Fj.semcdb.2020.11.003
TI - Alternative paths to telomere elongation.
T2 - Seminars in Cell and Developmental Biology
AU - Lee, Jennifer D
AU - LEE, JUN-YEOP
AU - Lee, Hyun-Sook
PY - 2021
DA - 2021/05/01 00:00:00
PB - Elsevier
SP - 88-96
VL - 113
SN - 1084-9521
SN - 1096-3634
ER -
BibTex
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BibTex Copy
@article{2021_Lee
author = {Jennifer D Lee and JUN-YEOP LEE and Hyun-Sook Lee},
title = {Alternative paths to telomere elongation.},
journal = {Seminars in Cell and Developmental Biology},
year = {2021},
volume = {113},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.semcdb.2020.11.003},
pages = {88--96},
doi = {10.1016/j.semcdb.2020.11.003}
}
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