Open Access
Safety and Health at Work, volume 12, issue 1, pages 127-132
Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers
Intayoung Unchisa
1
,
Wunnapuk Klintean
1
,
Kohsuwan Kanyapak
1
,
Brijnath Bianca
2
,
Khacha Ananda Supakit
1
1
Toxicology Unit, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
|
2
Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
|
Publication type: Journal Article
Publication date: 2021-03-01
Journal:
Safety and Health at Work
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.5
ISSN: 20937911, 20937997
PubMed ID:
33732538
Public Health, Environmental and Occupational Health
Safety, Risk, Reliability and Quality
Safety Research
Chemical Health and Safety
Abstract
Background Herbicides such as glyphosate, paraquat, and 2,4-dichlorophenoxyacetic acid have been reported to cause adverse side effects through production of reactive oxygen species. However, there were no data representing the adverse effects of a mixture herbicide usage in farmers, especially the changes in oxidative marker and antioxidant defense. This study aimed to determine the urinary malondialdehyde (MDA) and glutathione (GSH) level in farmers using mixed herbicides. Methods Ninety-three farmers were recruited, and two spot urine samples (before and after work) were collected. The urinary MDA level was evaluated by thiobarbituric acid reactive substance assay, and the urinary GSH level was determined using the enzymatic recycling method. Results Sixty-two percent of the participants were men, and 59% of the participants worked in a farm for 20–40 years. The common combinations of herbicide usage were glyphosate with 2,4-dichlorophenoxyacetic acid (36.5%). There was no significant difference between pre- and post-work urinary MDA and GSH levels among the 3 groups of herbicides. However, the urinary MDA levels in farmers using the combination of glyphosate and paraquat were significantly higher than those found in farmers using glyphosate alone. The associated factors with changes in MDA levels found that the exposure intensity index (B = 0.154), the cumulative exposure intensity index (B = 0.023), and wearing gloves while working (B = −2.347) were found to be significantly associated with MDA level. Conclusion The results suggest that the combined use of glyphosate and paraquat caused a significant increase in urinary MDA levels. Moreover, intensity of exposure to herbicide and wearing gloves were associated with the level of MDA.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Intayoung U. et al. Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers // Safety and Health at Work. 2021. Vol. 12. No. 1. pp. 127-132.
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Intayoung U., Wunnapuk K., Kohsuwan K., Brijnath B., Khacha Ananda S. Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers // Safety and Health at Work. 2021. Vol. 12. No. 1. pp. 127-132.
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TY - JOUR
DO - 10.1016/j.shaw.2020.09.011
UR - https://doi.org/10.1016%2Fj.shaw.2020.09.011
TI - Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers
T2 - Safety and Health at Work
AU - Intayoung, Unchisa
AU - Wunnapuk, Klintean
AU - Kohsuwan, Kanyapak
AU - Brijnath, Bianca
AU - Khacha Ananda, Supakit
PY - 2021
DA - 2021/03/01 00:00:00
PB - Elsevier
SP - 127-132
IS - 1
VL - 12
PMID - 33732538
SN - 2093-7911
SN - 2093-7997
ER -
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@article{2021_Intayoung,
author = {Unchisa Intayoung and Klintean Wunnapuk and Kanyapak Kohsuwan and Bianca Brijnath and Supakit Khacha Ananda},
title = {Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers},
journal = {Safety and Health at Work},
year = {2021},
volume = {12},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016%2Fj.shaw.2020.09.011},
number = {1},
pages = {127--132},
doi = {10.1016/j.shaw.2020.09.011}
}
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MLA
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Intayoung, Unchisa, et al. “Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers.” Safety and Health at Work, vol. 12, no. 1, Mar. 2021, pp. 127-132. https://doi.org/10.1016%2Fj.shaw.2020.09.011.