Structure, volume 15, issue 11, pages 1403-1412
Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding
1
Gene Expression and Regulation Program, The Wistar Institute, University of Pennsylvania, 3601 Spruce Street, Philadelphia, PA 19104, USA
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Publication type: Journal Article
Publication date: 2007-11-01
Molecular Biology
Structural Biology
Abstract
Telomerase, a ribonucleoprotein complex, replicates the linear ends of eukaryotic chromosomes, thus taking care of the "end of replication problem." TERT contains an essential and universally conserved domain (TRBD) that makes extensive contacts with the RNA (TER) component of the holoenzyme, and this interaction is thought to facilitate TERT/TER assembly and repeat-addition processivity. Here, we present a high-resolution structure of TRBD from Tetrahymena thermophila. The nearly all-helical structure comprises a nucleic acid-binding fold suitable for TER binding. An extended pocket on the surface of the protein, formed by two conserved motifs (CP and T motifs) comprises TRBD's RNA-binding pocket. The width and the chemical nature of this pocket suggest that it binds both single- and double-stranded RNA, possibly stem I, and the template boundary element (TBE). Moreover, the structure provides clues into the role of this domain in TERT/TER stabilization and telomerase repeat-addition processivity.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Rouda S., Skordalakes E. Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding // Structure. 2007. Vol. 15. No. 11. pp. 1403-1412.
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Rouda S., Skordalakes E. Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding // Structure. 2007. Vol. 15. No. 11. pp. 1403-1412.
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TY - JOUR
DO - 10.1016/j.str.2007.09.007
UR - https://doi.org/10.1016%2Fj.str.2007.09.007
TI - Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding
T2 - Structure
AU - Rouda, Susan
AU - Skordalakes, E.
PY - 2007
DA - 2007/11/01 00:00:00
PB - Elsevier
SP - 1403-1412
IS - 11
VL - 15
SN - 0969-2126
SN - 1878-4186
ER -
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@article{2007_Rouda,
author = {Susan Rouda and E. Skordalakes},
title = {Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding},
journal = {Structure},
year = {2007},
volume = {15},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.str.2007.09.007},
number = {11},
pages = {1403--1412},
doi = {10.1016/j.str.2007.09.007}
}
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MLA
Copy
Rouda, Susan, and E. Skordalakes. “Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding.” Structure, vol. 15, no. 11, Nov. 2007, pp. 1403-1412. https://doi.org/10.1016%2Fj.str.2007.09.007.