Journal of Supercritical Fluids, volume 158, pages 104748
Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics
Golubeva Elena N
1
,
Chumakova N.A.
1
,
Kuzin S. V.
1
,
Grigoriev I A
2
,
Kalai Tamas
3
,
Korotkevich A A
1
,
Bogorodsky S E
4
,
Krotova L I
4
,
Popov V.V.
4
,
Lunin V. V.
1
1
3
Institute of Organic and Medicinal Chemistry, University of Pécs, Medical School, Szigeti St. 12, H-7624, Pécs, Hungary
|
Publication type: Journal Article
Publication date: 2020-04-01
Journal:
Journal of Supercritical Fluids
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.9
ISSN: 08968446
Physical and Theoretical Chemistry
General Chemical Engineering
Condensed Matter Physics
Abstract
Poly(D,L-lactide) microparticles impregnated with a number of bioactive paramagnetic compounds have been fabricated using two SCF techniques: 1). PGSS (Particles from Gas Saturated Solution) and 2). polymer plasticization and swelling by supercritical carbon dioxide followed by its cryomilling. Electron paramagnetic resonance (EPR) spectroscopy manifested homogeneous spatial distribution for the most of these substances encapsulated into the polymer. Irreversible relaxation processes in the prepared polymer structures and formulations were not observed. The qualitative difference in the release kinetics of paramagnetic molecules of different structure from the polymer microparticles into the phosphate-buffered saline (PBS, pH = 7.4) was demonstrated. pH-sensitive ATI spin probe proved the decrease (up to ≤ 4.5) of local pH inside the microparticles during the first 9 days after its immersion in PBS.
Citations by journals
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1
2
3
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Russian Journal of Physical Chemistry B
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Russian Journal of Physical Chemistry B
3 publications, 30%
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Polymers
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2 publications, 20%
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Pharmaceutics
1 publication, 10%
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Antioxidants
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Antioxidants
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Journal of Supercritical Fluids
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Journal of Supercritical Fluids
1 publication, 10%
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Organic Preparations and Procedures International
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Organic Preparations and Procedures International
1 publication, 10%
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Molecules
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Molecules
1 publication, 10%
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1
2
3
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Citations by publishers
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1
2
3
4
5
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 50%
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Pleiades Publishing
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Pleiades Publishing
3 publications, 30%
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Elsevier
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Elsevier
1 publication, 10%
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Taylor & Francis
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Taylor & Francis
1 publication, 10%
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1
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3
4
5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Golubeva E. N. et al. Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics // Journal of Supercritical Fluids. 2020. Vol. 158. p. 104748.
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Golubeva E. N., Chumakova N., Kuzin S. V., Grigoriev I. A., Kalai T., Korotkevich A. A., Bogorodsky S. E., Krotova L. I., Popov V., Lunin V. V. Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics // Journal of Supercritical Fluids. 2020. Vol. 158. p. 104748.
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TY - JOUR
DO - 10.1016/j.supflu.2019.104748
UR - https://doi.org/10.1016%2Fj.supflu.2019.104748
TI - Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics
T2 - Journal of Supercritical Fluids
AU - Golubeva, Elena N
AU - Chumakova, N.A.
AU - Kuzin, S. V.
AU - Grigoriev, I A
AU - Kalai, Tamas
AU - Korotkevich, A A
AU - Bogorodsky, S E
AU - Krotova, L I
AU - Popov, V.V.
AU - Lunin, V. V.
PY - 2020
DA - 2020/04/01 00:00:00
PB - Elsevier
SP - 104748
VL - 158
SN - 0896-8446
ER -
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@article{2020_Golubeva,
author = {Elena N Golubeva and N.A. Chumakova and S. V. Kuzin and I A Grigoriev and Tamas Kalai and A A Korotkevich and S E Bogorodsky and L I Krotova and V.V. Popov and V. V. Lunin},
title = {Paramagnetic bioactives encapsulated in poly(D,L-lactide) microparticules: Spatial distribution and in vitro release kinetics},
journal = {Journal of Supercritical Fluids},
year = {2020},
volume = {158},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.supflu.2019.104748},
pages = {104748},
doi = {10.1016/j.supflu.2019.104748}
}
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