Talanta, volume 230, pages 122310

Determination of nitrofuran metabolites in honey using a new derivatization reagent, magnetic solid-phase extraction and LC–MS/MS

Melekhin Artem O ^{1, 2}

Apyari Vladimir ³

Dmitrienko S ³

Tolmacheva Veronika V. ³

Shubina Elena G

Grudev Artyom I ²

shubina Elena S. ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Analytical Chemistry Division, Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119991, Russia |

Central Scientific Methodological Veterinary Laboratory, Orangereynaya st., 23, 111622, Moscow, Russia. |

Analytical Chemistry Division, Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia. |

Publication type: Journal Article

Publication date: 2021-08-01

Elsevier

Journal: Talanta

Quartile SCImago

Quartile WOS

Impact factor: 6.1

ISSN: 00399140, 18733573

DOI: 10.1016/j.talanta.2021.122310

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Analytical Chemistry

Abstract

In this study, 5-nitro-2-furaldehyde (5-NFA) was proposed as a new derivatizing agent for nitrofuran metabolites. It reacts with nitrofuran metabolites producing the parent nitrofurans (furazolidone, furaltadone, nitrofurantoin, and nitrofurazone). Magnetic hypercrosslinked polystyrene (HCP/Fe3O4) was first used for magnetic solid phase extraction (MSPE) clean-up before the determination of nitrofuran metabolite derivatives in honey via LC-MS/MS. Main parameters affecting the derivatization and MSPE efficiency were investigated in detail and the optimal conditions were found. The method was validated using honey spiked with the four metabolites at 1, 2 and 200 μg kg-1. Recoveries of >85% were achieved for the all analytes. The matrix calibration curve was fitted with the correlation coefficient (R2) > 0.99 in the range of 1-200 μg kg-1. Precision values expressed as relative standard deviation (RSD) were <12% and <15% for intra-day and inter-day precision, respectively. The limits of detection (LODs) for the nitrofuran metabolites were of 0.1-0.3 μg kg-1 and the limits of quantitation (LOQs) were of 0.3-1.0 μg kg-1. The proposed LC-MS/MS method was applied to the analysis of real honey samples.

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Journal of Pharmaceutical and Biomedical Analysis	Journal of Pharmaceutical and Biomedical Analysis, 1, 3.57% Journal of Pharmaceutical and Biomedical Analysis 1 publication, 3.57%
Science of the Total Environment	Science of the Total Environment, 1, 3.57% Science of the Total Environment 1 publication, 3.57%
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Citations by publishers

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Elsevier	Elsevier, 15, 53.57% Elsevier 15 publications, 53.57%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 17.86% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 17.86%
Springer Nature	Springer Nature, 3, 10.71% Springer Nature 3 publications, 10.71%
Pleiades Publishing	Pleiades Publishing, 2, 7.14% Pleiades Publishing 2 publications, 7.14%
Frontiers Media S.A.	Frontiers Media S.A., 1, 3.57% Frontiers Media S.A. 1 publication, 3.57%
Xi'an Jiaotong University	Xi'an Jiaotong University, 1, 3.57% Xi'an Jiaotong University 1 publication, 3.57%
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Melekhin A. O. et al. Determination of nitrofuran metabolites in honey using a new derivatization reagent, magnetic solid-phase extraction and LC–MS/MS // Talanta. 2021. Vol. 230. p. 122310.

GOST all authors (up to 50) Copy

Melekhin A. O., Tolmacheva V. V., Shubina E. G., Dmitrienko S., Apyari V., Grudev A. I., shubina E. S. Determination of nitrofuran metabolites in honey using a new derivatization reagent, magnetic solid-phase extraction and LC–MS/MS // Talanta. 2021. Vol. 230. p. 122310.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.talanta.2021.122310

UR - https://doi.org/10.1016%2Fj.talanta.2021.122310

TI - Determination of nitrofuran metabolites in honey using a new derivatization reagent, magnetic solid-phase extraction and LC–MS/MS

T2 - Talanta

AU - Melekhin, Artem O

AU - Tolmacheva, Veronika V.

AU - Shubina, Elena G

AU - Dmitrienko, S

AU - Apyari, Vladimir

AU - Grudev, Artyom I

AU - shubina, Elena S.

PY - 2021

DA - 2021/08/01 00:00:00

PB - Elsevier

SP - 122310

VL - 230

SN - 0039-9140

SN - 1873-3573

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Melekhin,

author = {Artem O Melekhin and Veronika V. Tolmacheva and Elena G Shubina and S Dmitrienko and Vladimir Apyari and Artyom I Grudev and Elena S. shubina},

title = {Determination of nitrofuran metabolites in honey using a new derivatization reagent, magnetic solid-phase extraction and LC–MS/MS},

journal = {Talanta},

year = {2021},

volume = {230},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016%2Fj.talanta.2021.122310},

pages = {122310},

doi = {10.1016/j.talanta.2021.122310}

}

Found error?

Publisher

Elsevier

Journal

Talanta

Quartile SCImago

Quartile WOS

Impact factor

6.1

ISSN

00399140 (Print)
18733573 (Electronic)

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