Talanta, volume 253, pages 124035
A de novo nanoplatform for the delivery of metal-based drugs studied with high-resolution ICP-MS
Publication type: Journal Article
Publication date: 2023-02-01
Analytical Chemistry
Abstract
The development of nanomaterials designed for enhanced and controlled delivery of metallodrugs is a challenging task and requires using reliable analytical tools. In this bioanalytical study, we employed high-resolution inductively coupled plasma-mass spectrometry to assess a novel type of nanocarrier based on cation-exchanger nanoparticles (CENs). By recording the signals of Pt and S isotopes, it was shown that direct interaction between CENs and activated cisplatin drug results in a fast and high drug loading (up to 0.12 g Pt per gram) and in human serum environment the loaded CENs are rapidly converted into the protein-bound form but do not discharge the payload. To gain an insight into the composition of the protein corona, the relative abundances of proteins attached to the surfaces of parent and cisplatin-loaded CENs were determined using LC-MS/MS. The potential of CENs as a nanocarrier for smart drug delivery has been further confirmed by a sizeable release of cisplatin under conditions relevant to cancer cytosol (but negligible in normal cytosol setting). It is believed that binding to the CENs would provide the cisplatin treatment more targeted action, higher (when necessary) dosages, and possibly reduced side effects. • ICP-MS is shown to serve as a useful tool for testing novel drug nanocarriers. • Nano-sized ion-exchanger is proposed first-ever as a metallodrug delivery vehicle. • A fast and high loading of cisplatin is viable due to dual surface/spatial sorption. • The payload is shown to be stable in human serum environment. • In vitro drug release proves effective under conditions relevant to cancer cytosol.
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Molecules
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Molecules
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
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Kuznetsova O. V. A de novo nanoplatform for the delivery of metal-based drugs studied with high-resolution ICP-MS // Talanta. 2023. Vol. 253. p. 124035.
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Kuznetsova O. V. A de novo nanoplatform for the delivery of metal-based drugs studied with high-resolution ICP-MS // Talanta. 2023. Vol. 253. p. 124035.
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TY - JOUR
DO - 10.1016/j.talanta.2022.124035
UR - https://doi.org/10.1016%2Fj.talanta.2022.124035
TI - A de novo nanoplatform for the delivery of metal-based drugs studied with high-resolution ICP-MS
T2 - Talanta
AU - Kuznetsova, Olga V.
PY - 2023
DA - 2023/02/01 00:00:00
PB - Elsevier
SP - 124035
VL - 253
SN - 0039-9140
SN - 1873-3573
ER -
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@article{2023_Kuznetsova
author = {Olga V. Kuznetsova},
title = {A de novo nanoplatform for the delivery of metal-based drugs studied with high-resolution ICP-MS},
journal = {Talanta},
year = {2023},
volume = {253},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.talanta.2022.124035},
pages = {124035},
doi = {10.1016/j.talanta.2022.124035}
}