One-pot synthesis of 4-heteroaryl-1,2-dihydro-3-benzazepines from 3,4-dihydroisoquinolinium salts or pseudo bases
Alexander A Zubenko
1
,
Viktor G Kartsev
2
,
А. С. Морковник
3
,
Ludmila N Divaeva
3
,
Gennadii S Borodkin
3
,
Alexander I Klimenko
5
1
Federal State Budgetary Scientific Institution North-Caucasus Zonal Scientific Research Veterinary Institute, Novocherkassk 346406, Russia
|
2
InterBioScreen Ltd., Moscow 119019, Russia
|
Publication type: Journal Article
Publication date: 2017-03-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A novel one-pot synthetic route to the poorly studied 4-heteroaryl-1,2-dihydro-3-benzazepine motif from 3,4-dihydroisoquinolinium compounds is described. The synthetic approach is based on heterocyclic ring expansion of isoquinoline substrates upon reaction with chloromethyl-substituted heterocycles. The scope and limitations of the reaction were investigated to give a series of novel heteroaryl-3-benzazepines.
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Zubenko A. A. et al. One-pot synthesis of 4-heteroaryl-1,2-dihydro-3-benzazepines from 3,4-dihydroisoquinolinium salts or pseudo bases // Tetrahedron Letters. 2017. Vol. 58. No. 12. pp. 1233-1236.
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Zubenko A. A., Kartsev V. G., Морковник А. С., Divaeva L. N., Alexeenko D. V., Suponitsky K. Y., Borodkin G. S., Klimenko A. I. One-pot synthesis of 4-heteroaryl-1,2-dihydro-3-benzazepines from 3,4-dihydroisoquinolinium salts or pseudo bases // Tetrahedron Letters. 2017. Vol. 58. No. 12. pp. 1233-1236.
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RIS
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TY - JOUR
DO - 10.1016/j.tetlet.2017.02.036
UR - https://doi.org/10.1016/j.tetlet.2017.02.036
TI - One-pot synthesis of 4-heteroaryl-1,2-dihydro-3-benzazepines from 3,4-dihydroisoquinolinium salts or pseudo bases
T2 - Tetrahedron Letters
AU - Zubenko, Alexander A
AU - Kartsev, Viktor G
AU - Морковник, А. С.
AU - Divaeva, Ludmila N
AU - Alexeenko, Danil V
AU - Suponitsky, Kyrill Yu.
AU - Borodkin, Gennadii S
AU - Klimenko, Alexander I
PY - 2017
DA - 2017/03/01
PB - Elsevier
SP - 1233-1236
IS - 12
VL - 58
SN - 0040-4039
SN - 1873-3581
ER -
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BibTex (up to 50 authors)
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@article{2017_Zubenko,
author = {Alexander A Zubenko and Viktor G Kartsev and А. С. Морковник and Ludmila N Divaeva and Danil V Alexeenko and Kyrill Yu. Suponitsky and Gennadii S Borodkin and Alexander I Klimenko},
title = {One-pot synthesis of 4-heteroaryl-1,2-dihydro-3-benzazepines from 3,4-dihydroisoquinolinium salts or pseudo bases},
journal = {Tetrahedron Letters},
year = {2017},
volume = {58},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.tetlet.2017.02.036},
number = {12},
pages = {1233--1236},
doi = {10.1016/j.tetlet.2017.02.036}
}
Cite this
MLA
Copy
Zubenko, Alexander A., et al. “One-pot synthesis of 4-heteroaryl-1,2-dihydro-3-benzazepines from 3,4-dihydroisoquinolinium salts or pseudo bases.” Tetrahedron Letters, vol. 58, no. 12, Mar. 2017, pp. 1233-1236. https://doi.org/10.1016/j.tetlet.2017.02.036.
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