Open Access
Trends in Biochemical Sciences, volume 43, issue 9, pages 668-684
How Macrolide Antibiotics Work
1
Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
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Publication type: Journal Article
Publication date: 2018-09-01
Journal:
Trends in Biochemical Sciences
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 13.8
ISSN: 03765067, 09680004, 13624326
PubMed ID:
30054232
Biochemistry
Molecular Biology
Abstract
Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been viewed as 'tunnel plugs' that stop the synthesis of every protein. More recent evidence, however, demonstrates that macrolides selectively inhibit the translation of a subset of cellular proteins, and that their action crucially depends on the nascent protein sequence and on the antibiotic structure. Therefore, macrolides emerge as modulators of translation rather than as global inhibitors of protein synthesis. The context-specific action of macrolides is the basis for regulating the expression of resistance genes. Understanding the details of the mechanism of macrolide action may inform rational design of new drugs and unveil important principles of translation regulation.
Citations by journals
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Antibiotics
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Antibiotics
9 publications, 4.64%
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Nature Communications
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Nature Communications
8 publications, 4.12%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
5 publications, 2.58%
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Frontiers in Microbiology
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Frontiers in Microbiology
5 publications, 2.58%
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Molecules
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Molecules
4 publications, 2.06%
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Marine Drugs
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Marine Drugs
4 publications, 2.06%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
4 publications, 2.06%
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Nature Chemical Biology
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Nature Chemical Biology
3 publications, 1.55%
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Microorganisms
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Microorganisms
3 publications, 1.55%
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Biochemistry (Moscow)
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Biochemistry (Moscow)
2 publications, 1.03%
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mBio
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mBio
2 publications, 1.03%
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Open Biochemistry Journal
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Open Biochemistry Journal
2 publications, 1.03%
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Microbiology
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Microbiology
2 publications, 1.03%
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Pharmaceuticals
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Pharmaceuticals
2 publications, 1.03%
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Infection
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Infection
2 publications, 1.03%
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Helicobacter
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Helicobacter
2 publications, 1.03%
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Journal of Hazardous Materials
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Journal of Hazardous Materials
2 publications, 1.03%
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Journal of Pharmaceutical and Biomedical Analysis
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Journal of Pharmaceutical and Biomedical Analysis
2 publications, 1.03%
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Medicinal Research Reviews
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Medicinal Research Reviews
2 publications, 1.03%
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Experimental Dermatology
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Experimental Dermatology
2 publications, 1.03%
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Journal of Antimicrobial Chemotherapy
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Journal of Antimicrobial Chemotherapy
2 publications, 1.03%
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Nucleic Acids Research
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Nucleic Acids Research
2 publications, 1.03%
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
2 publications, 1.03%
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Microbial genomics
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Microbial genomics
1 publication, 0.52%
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Current Pharmaceutical Design
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Current Pharmaceutical Design
1 publication, 0.52%
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Open Biology
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Open Biology
1 publication, 0.52%
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Journal of Molecular Medicine
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Journal of Molecular Medicine
1 publication, 0.52%
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Биохимия
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Биохимия
1 publication, 0.52%
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Toxins
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Toxins
1 publication, 0.52%
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9
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Citations by publishers
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5
10
15
20
25
30
35
40
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
37 publications, 19.07%
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Elsevier
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Elsevier
28 publications, 14.43%
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Springer Nature
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Springer Nature
25 publications, 12.89%
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Wiley
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Wiley
13 publications, 6.7%
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Frontiers Media S.A.
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Frontiers Media S.A.
9 publications, 4.64%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
8 publications, 4.12%
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Taylor & Francis
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Taylor & Francis
5 publications, 2.58%
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Bentham Science
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Bentham Science
4 publications, 2.06%
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Oxford University Press
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Oxford University Press
4 publications, 2.06%
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Hindawi Limited
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Hindawi Limited
4 publications, 2.06%
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Pleiades Publishing
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Pleiades Publishing
3 publications, 1.55%
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American Society for Microbiology
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American Society for Microbiology
3 publications, 1.55%
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Microbiology Society
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Microbiology Society
3 publications, 1.55%
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Dove Medical Press
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Dove Medical Press
2 publications, 1.03%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
2 publications, 1.03%
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Thieme
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Thieme
2 publications, 1.03%
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The Royal Society
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The Royal Society
1 publication, 0.52%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
1 publication, 0.52%
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American Society of Agronomy
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American Society of Agronomy
1 publication, 0.52%
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BMJ
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BMJ
1 publication, 0.52%
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Colegio Brasileiro de Patologia Animal
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Colegio Brasileiro de Patologia Animal, 1, 0.52%
Colegio Brasileiro de Patologia Animal
1 publication, 0.52%
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Scientific Research Publishing
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Scientific Research Publishing
1 publication, 0.52%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 0.52%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 0.52%
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American Association for Cancer Research (AACR)
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American Association for Cancer Research (AACR)
1 publication, 0.52%
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Belgorod National Research University
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Belgorod National Research University
1 publication, 0.52%
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Sociedade Brasileira de Genetica
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Sociedade Brasileira de Genetica, 1, 0.52%
Sociedade Brasileira de Genetica
1 publication, 0.52%
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Wolters Kluwer Health
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Wolters Kluwer Health
1 publication, 0.52%
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5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Vázquez Laslop N., Mankin A. S. How Macrolide Antibiotics Work // Trends in Biochemical Sciences. 2018. Vol. 43. No. 9. pp. 668-684.
GOST all authors (up to 50)
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Vázquez Laslop N., Mankin A. S. How Macrolide Antibiotics Work // Trends in Biochemical Sciences. 2018. Vol. 43. No. 9. pp. 668-684.
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RIS
Copy
TY - JOUR
DO - 10.1016/j.tibs.2018.06.011
UR - https://doi.org/10.1016%2Fj.tibs.2018.06.011
TI - How Macrolide Antibiotics Work
T2 - Trends in Biochemical Sciences
AU - Vázquez Laslop, Nora
AU - Mankin, Alexander S.
PY - 2018
DA - 2018/09/01 00:00:00
PB - Elsevier
SP - 668-684
IS - 9
VL - 43
PMID - 30054232
SN - 0376-5067
SN - 0968-0004
SN - 1362-4326
ER -
Cite this
BibTex
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@article{2018_Vázquez Laslop,
author = {Nora Vázquez Laslop and Alexander S. Mankin},
title = {How Macrolide Antibiotics Work},
journal = {Trends in Biochemical Sciences},
year = {2018},
volume = {43},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.tibs.2018.06.011},
number = {9},
pages = {668--684},
doi = {10.1016/j.tibs.2018.06.011}
}
Cite this
MLA
Copy
Vázquez Laslop, Nora, and Alexander S. Mankin. “How Macrolide Antibiotics Work.” Trends in Biochemical Sciences, vol. 43, no. 9, Sep. 2018, pp. 668-684. https://doi.org/10.1016%2Fj.tibs.2018.06.011.