Translational Research, volume 202, pages 35-51

Targeting mitochondria in cancer: current concepts and immunotherapy approaches

Pustylnikov Sergey 1
Costabile Francesca 1
Beghi Silvia 1
Facciabene Andrea 2
1
 
Department of Radiation Oncology, Perelman School of Medicine University of Pennsylvania, Philadelphia, Pennsylvania.
2
 
Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Publication typeJournal Article
Publication date2018-12-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor7.8
ISSN19315244
General Medicine
Public Health, Environmental and Occupational Health
Physiology (medical)
Biochemistry (medical)
Abstract
An essential advantage during eukaryotic cell evolution was the acquisition of a network of mitochondria as a source of energy for cell metabolism and contrary to conventional wisdom, functional mitochondria are essential for the cancer cell. Multiple aspects of mitochondrial biology beyond bioenergetics support transformation including mitochondrial biogenesis, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. In cancer, the metabolism of cells is reprogrammed for energy generation from oxidative phosphorylation to aerobic glycolysis and impacts cancer mitochondrial function. Furthermore cancer cells can also modulate energy metabolism within the cancer microenvironment including immune cells and induce "metabolic anergy" of antitumor immune response. Classical approaches targeting the mitochondria of cancer cells usually aim at inducing changing energy metabolism or directly affecting functions of mitochondrial antiapoptotic proteins but most of such approaches miss the required specificity of action and carry important side effects. Several types of cancers harbor somatic mitochondrial DNA mutations and specific immune response to mutated mitochondrial proteins has been observed. An attractive alternative way to target the mitochondria in cancer cells is the induction of an adaptive immune response against mutated mitochondrial proteins. Here, we review the cancer cell-intrinsic and cell-extrinsic mechanisms through which mitochondria influence all steps of oncogenesis, with a focus on the therapeutic potential of targeting mitochondrial DNA mutations or Tumor Associated Mitochondria Antigens using the immune system.

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Pustylnikov S. et al. Targeting mitochondria in cancer: current concepts and immunotherapy approaches // Translational Research. 2018. Vol. 202. pp. 35-51.
GOST all authors (up to 50) Copy
Pustylnikov S., Costabile F., Beghi S., Facciabene A. Targeting mitochondria in cancer: current concepts and immunotherapy approaches // Translational Research. 2018. Vol. 202. pp. 35-51.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.trsl.2018.07.013
UR - https://doi.org/10.1016%2Fj.trsl.2018.07.013
TI - Targeting mitochondria in cancer: current concepts and immunotherapy approaches
T2 - Translational Research
AU - Pustylnikov, Sergey
AU - Costabile, Francesca
AU - Beghi, Silvia
AU - Facciabene, Andrea
PY - 2018
DA - 2018/12/01 00:00:00
PB - Elsevier
SP - 35-51
VL - 202
PMID - 30144423
SN - 1931-5244
ER -
BibTex
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BibTex Copy
@article{2018_Pustylnikov
author = {Sergey Pustylnikov and Francesca Costabile and Silvia Beghi and Andrea Facciabene},
title = {Targeting mitochondria in cancer: current concepts and immunotherapy approaches},
journal = {Translational Research},
year = {2018},
volume = {202},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.trsl.2018.07.013},
pages = {35--51},
doi = {10.1016/j.trsl.2018.07.013}
}
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