Translational Research, volume 202, pages 35-51
Targeting mitochondria in cancer: current concepts and immunotherapy approaches
1
Department of Radiation Oncology, Perelman School of Medicine University of Pennsylvania, Philadelphia, Pennsylvania.
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2
Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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Publication type: Journal Article
Publication date: 2018-12-01
Journal:
Translational Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.8
ISSN: 19315244
PubMed ID:
30144423
General Medicine
Public Health, Environmental and Occupational Health
Physiology (medical)
Biochemistry (medical)
Abstract
An essential advantage during eukaryotic cell evolution was the acquisition of a network of mitochondria as a source of energy for cell metabolism and contrary to conventional wisdom, functional mitochondria are essential for the cancer cell. Multiple aspects of mitochondrial biology beyond bioenergetics support transformation including mitochondrial biogenesis, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. In cancer, the metabolism of cells is reprogrammed for energy generation from oxidative phosphorylation to aerobic glycolysis and impacts cancer mitochondrial function. Furthermore cancer cells can also modulate energy metabolism within the cancer microenvironment including immune cells and induce "metabolic anergy" of antitumor immune response. Classical approaches targeting the mitochondria of cancer cells usually aim at inducing changing energy metabolism or directly affecting functions of mitochondrial antiapoptotic proteins but most of such approaches miss the required specificity of action and carry important side effects. Several types of cancers harbor somatic mitochondrial DNA mutations and specific immune response to mutated mitochondrial proteins has been observed. An attractive alternative way to target the mitochondria in cancer cells is the induction of an adaptive immune response against mutated mitochondrial proteins. Here, we review the cancer cell-intrinsic and cell-extrinsic mechanisms through which mitochondria influence all steps of oncogenesis, with a focus on the therapeutic potential of targeting mitochondrial DNA mutations or Tumor Associated Mitochondria Antigens using the immune system.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Pustylnikov S. et al. Targeting mitochondria in cancer: current concepts and immunotherapy approaches // Translational Research. 2018. Vol. 202. pp. 35-51.
GOST all authors (up to 50)
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Pustylnikov S., Costabile F., Beghi S., Facciabene A. Targeting mitochondria in cancer: current concepts and immunotherapy approaches // Translational Research. 2018. Vol. 202. pp. 35-51.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.trsl.2018.07.013
UR - https://doi.org/10.1016%2Fj.trsl.2018.07.013
TI - Targeting mitochondria in cancer: current concepts and immunotherapy approaches
T2 - Translational Research
AU - Pustylnikov, Sergey
AU - Costabile, Francesca
AU - Beghi, Silvia
AU - Facciabene, Andrea
PY - 2018
DA - 2018/12/01 00:00:00
PB - Elsevier
SP - 35-51
VL - 202
PMID - 30144423
SN - 1931-5244
ER -
Cite this
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@article{2018_Pustylnikov
author = {Sergey Pustylnikov and Francesca Costabile and Silvia Beghi and Andrea Facciabene},
title = {Targeting mitochondria in cancer: current concepts and immunotherapy approaches},
journal = {Translational Research},
year = {2018},
volume = {202},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.trsl.2018.07.013},
pages = {35--51},
doi = {10.1016/j.trsl.2018.07.013}
}