Experimental Cell Research, volume 329, issue 1, pages 69-77

Roles of chromatin remodellers in DNA double strand break repair

Jeggo Penny A. 1
Downs Jessica L. 1
1
 
Genome Damage and Stability Centre, Life Sciences, University of Sussex, Brighton BN19RQ, UK.
Publication typeJournal Article
Publication date2014-11-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor3.7
ISSN00144827, 10902422
Cell Biology
Abstract
Now that we have a good understanding of the DNA double strand break (DSB) repair mechanisms and DSB-induced damage signalling, attention is focusing on the changes to the chromatin environment needed for efficient DSB repair. Mutations in chromatin remodelling complexes have been identified in cancers, making it important to evaluate how they impact upon genomic stability. Our current understanding of the DSB repair pathways suggests that each one has distinct requirements for chromatin remodelling. Moreover, restricting the extent of chromatin modifications could be a significant factor regulating the decision of pathway usage. In this review, we evaluate the distinct DSB repair pathways for their potential need for chromatin remodelling and review the roles of ATP-driven chromatin remodellers in the pathways.

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Jeggo P. A., Downs J. L. Roles of chromatin remodellers in DNA double strand break repair // Experimental Cell Research. 2014. Vol. 329. No. 1. pp. 69-77.
GOST all authors (up to 50) Copy
Jeggo P. A., Downs J. L. Roles of chromatin remodellers in DNA double strand break repair // Experimental Cell Research. 2014. Vol. 329. No. 1. pp. 69-77.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.yexcr.2014.09.023
UR - https://doi.org/10.1016%2Fj.yexcr.2014.09.023
TI - Roles of chromatin remodellers in DNA double strand break repair
T2 - Experimental Cell Research
AU - Jeggo, Penny A.
AU - Downs, Jessica L.
PY - 2014
DA - 2014/11/01 00:00:00
PB - Elsevier
SP - 69-77
IS - 1
VL - 329
SN - 0014-4827
SN - 1090-2422
ER -
BibTex |
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BibTex Copy
@article{2014_Jeggo,
author = {Penny A. Jeggo and Jessica L. Downs},
title = {Roles of chromatin remodellers in DNA double strand break repair},
journal = {Experimental Cell Research},
year = {2014},
volume = {329},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.yexcr.2014.09.023},
number = {1},
pages = {69--77},
doi = {10.1016/j.yexcr.2014.09.023}
}
MLA
Cite this
MLA Copy
Jeggo, Penny A., and Jessica L. Downs. “Roles of chromatin remodellers in DNA double strand break repair.” Experimental Cell Research, vol. 329, no. 1, Nov. 2014, pp. 69-77. https://doi.org/10.1016%2Fj.yexcr.2014.09.023.
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