Molecular Therapy, volume 26, issue 7, pages 1685-1693
Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.
An Songtao
1, 2
,
Wang Xiaoyin
3
,
Ruck Melissa A
4
,
Kostyushev Dmitry S
,
Varga Mónika
3
,
Luu Emmy
5
,
Derakhshandeh Ronak
3
,
Suchkov Sergey V.
6, 7
,
Hermiston Michelle L.
,
Kogan Scott C
,
Springer Matthew L.
,
Rodriguez Hilda J.
5, 8
,
KOGAN SCOTT C.
,
Hermiston M. L.
8, 9
,
Springer Matthew L.
8
1
Division of Cardiology, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan 450003, China.
|
2
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
|
3
Cardiovascular Research Institute, University of California-San Francisco, San Francisco, CA, 94143, USA.
|
4
Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA,
|
5
Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143, USA
|
8
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
|
9
Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA
|
Publication type: Journal Article
Publication date: 2018-07-01
Journal:
Molecular Therapy
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 12.4
ISSN: 15250016, 15250024
PubMed ID:
29914756
Drug Discovery
Molecular Biology
Pharmacology
Genetics
Molecular Medicine
Abstract
Treatment of myocardial infarction (MI) with bone marrow cells (BMCs) improves post-MI cardiac function in rodents. However, clinical trials of BMC therapy have been less effective. While most rodent experiments use young healthy donors, patients undergoing autologous cell therapy are older and post-MI. We previously demonstrated that BMCs from aged and post-MI donor mice are therapeutically impaired, and that donor MI induces inflammatory changes in BMC composition including reduced levels of B lymphocytes. Here, we hypothesized that B cell alterations in bone marrow account for the reduced therapeutic potential of post-MI and aged donor BMCs. Injection of BMCs from increasingly aged donor mice resulted in progressively poorer cardiac function and larger infarct size. Flow cytometry revealed fewer B cells in aged donor bone marrow. Therapeutic efficacy of young healthy donor BMCs was reduced by depletion of B cells. Implantation of intact or lysed B cells improved cardiac function, whereas intact or lysed T cells provided only minor benefit. We conclude that B cells play an important paracrine role in effective BMC therapy for MI. Reduction of bone marrow B cells because of age or MI may partially explain why clinical autologous cell therapy has not matched the success of rodent experiments.
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PLoS ONE
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1 publication, 16.67%
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1 publication, 16.67%
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1
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Citations by publishers
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1
2
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Frontiers Media S.A.
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2 publications, 33.33%
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Public Library of Science (PLoS)
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1 publication, 16.67%
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Dove Medical Press
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1 publication, 16.67%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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An S. et al. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. // Molecular Therapy. 2018. Vol. 26. No. 7. pp. 1685-1693.
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An S., Wang X., Ruck M. A., Kostyushev D. S., Varga M., Luu E., Derakhshandeh R., Suchkov S. V., Hermiston M. L., Kogan S. C., Springer M. L., Rodriguez H. J., Kostyushev D., KOGAN S. C., Hermiston M. L., Springer M. L. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. // Molecular Therapy. 2018. Vol. 26. No. 7. pp. 1685-1693.
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TY - JOUR
DO - 10.1016/j.ymthe.2018.05.015
UR - https://doi.org/10.1016%2Fj.ymthe.2018.05.015
TI - Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.
T2 - Molecular Therapy
AU - An, Songtao
AU - Wang, Xiaoyin
AU - Ruck, Melissa A
AU - Kostyushev, Dmitry S
AU - Varga, Mónika
AU - Luu, Emmy
AU - Derakhshandeh, Ronak
AU - Suchkov, Sergey V.
AU - Hermiston, Michelle L.
AU - Kogan, Scott C
AU - Springer, Matthew L.
AU - Rodriguez, Hilda J.
AU - Kostyushev, Dmitry
AU - KOGAN, SCOTT C.
AU - Hermiston, M. L.
AU - Springer, Matthew L.
PY - 2018
DA - 2018/07/01 00:00:00
PB - Elsevier
SP - 1685-1693
IS - 7
VL - 26
PMID - 29914756
SN - 1525-0016
SN - 1525-0024
ER -
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@article{2018_An,
author = {Songtao An and Xiaoyin Wang and Melissa A Ruck and Dmitry S Kostyushev and Mónika Varga and Emmy Luu and Ronak Derakhshandeh and Sergey V. Suchkov and Michelle L. Hermiston and Scott C Kogan and Matthew L. Springer and Hilda J. Rodriguez and Dmitry Kostyushev and SCOTT C. KOGAN and M. L. Hermiston and Matthew L. Springer},
title = {Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.},
journal = {Molecular Therapy},
year = {2018},
volume = {26},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016%2Fj.ymthe.2018.05.015},
number = {7},
pages = {1685--1693},
doi = {10.1016/j.ymthe.2018.05.015}
}
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MLA
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An, Songtao, et al. “Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes..” Molecular Therapy, vol. 26, no. 7, Jul. 2018, pp. 1685-1693. https://doi.org/10.1016%2Fj.ymthe.2018.05.015.
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