Biomacromolecules, volume 22, issue 3, pages 1167-1176
PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy.
3
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China
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Publication type: Journal Article
Publication date: 2021-02-10
Journal:
Biomacromolecules
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.2
ISSN: 15257797, 15264602
Materials Chemistry
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
In this study, we reported a nanocomplex (PAF) of PEGylated polygalacturonic acid, 5,10,15,20-tetrakis (4-aminophenyl) porphyrin (TAPP), and Fe3+ for photodynamic therapy (PDT)-enhanced ferroptosis in cancer treatment. PAF exhibited a size of 135 nm and a TAPP and Fe3+ loading content of 6.99 and 0.77%, respectively. The singlet oxygen (1O2) generation capacity of TAPP can be activated and significantly enhanced at acidic pH (4.5-5.0). Besides, the enhanced near-infrared absorption of TAPP at acidic pH enabled a further increase in 1O2 generation capability by a near-infrared laser (760 nm). The polysaccharide-based polymer carrier offers excellent biocompatibility, and PAF displayed a proliferative effect in both normal (L929) and cancer (B16) cells. However, upon light irradiation, PAF exhibited high toxicity to B16 melanoma cells by intracellular reactive oxygen species elevation, glutathione depletion, and lipid peroxidation. PAF displayed a much better anticancer effect than the nanocomplex containing Fe3+ or TAPP alone, indicating the PDT-enhanced ferroptosis in PAF. This study suggested that PDT-enhanced ferroptosis could be a facile and robust strategy of nanotherapeutics with high potency, tumor selectivity, and excellent biocompatibility.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Li J. et al. PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy. // Biomacromolecules. 2021. Vol. 22. No. 3. pp. 1167-1176.
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Li J., Li J., Pu Y., LI S., Gao W., He B. PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy. // Biomacromolecules. 2021. Vol. 22. No. 3. pp. 1167-1176.
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TY - JOUR
DO - 10.1021/acs.biomac.0c01679
UR - https://doi.org/10.1021%2Facs.biomac.0c01679
TI - PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy.
T2 - Biomacromolecules
AU - Li, Junhua
AU - LI, SAI
AU - Pu, Yuji
AU - Gao, Wenxia
AU - He, Bin
AU - Li, Jing
PY - 2021
DA - 2021/02/10 00:00:00
PB - American Chemical Society (ACS)
SP - 1167-1176
IS - 3
VL - 22
SN - 1525-7797
SN - 1526-4602
ER -
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@article{2021_Li,
author = {Junhua Li and SAI LI and Yuji Pu and Wenxia Gao and Bin He and Jing Li},
title = {PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy.},
journal = {Biomacromolecules},
year = {2021},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021%2Facs.biomac.0c01679},
number = {3},
pages = {1167--1176},
doi = {10.1021/acs.biomac.0c01679}
}
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MLA
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Li, Jing, et al. “PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy..” Biomacromolecules, vol. 22, no. 3, Feb. 2021, pp. 1167-1176. https://doi.org/10.1021%2Facs.biomac.0c01679.