Inorganic Chemistry, volume 60, issue 9, pages 6410-6420
Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light.
Publication type: Journal Article
Publication date: 2021-04-12
Journal:
Inorganic Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.6
ISSN: 00201669, 1520510X
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
Maloplatin-B, a cisplatin-based complex, namely [Pt(A-BOD)(NH3)2](NO3) (Pt-A-BOD) with a pendant boron-dipyrromethene (BODIPY) moiety, where HA-BOD is a methyl malonyl chloride derived monostyryl BODIPY ligand, was designed and developed as near-IR light (600-720 nm) organelle-targeting photodynamic therapy agent. The complex [Pt(acac)(NH3)2](NO3) (Pt-Ac) was used as a control. Pt-A-BOD displayed an absorption band at 616 nm (ε = 2.9 × 104 M-1 cm-1) in 10% dimethyl sulfoxide/Dulbecco's Modified Eagle's Medium (DMSO/DMEM, pH 7.2). This complex displayed a broad emission band within 650-850 nm with a λem value of 720 nm in 10% DMSO-DMEM (pH 7.2) upon excitation (λex) at 615 nm with a large Stokes shift. The fluorescence quantum yield (ΦF) value for Pt-A-BOD is 0.032 and for the ligand HA-BOD is 0.24. The BODIPY complex and ligand showed the formation of singlet oxygen as the ROS (reactive oxygen species) on irradiation with near-IR red light of 660 nm, as evidenced from a 1,3-diphenylisobenzofuran (DPBF) assay. The complex displayed remarkable apoptotic NIR light-induced PDT activity with half-maximum inhibitory concentration values (IC50) of 1.6-2.4 μM in A549 lung and HeLa cervical cancer cells, while it was less active in the dark. The cellular ROS generation by the complex in red light was ascertained by a DCFDA (2',7'-dichlorofluorescein diacetate) assay. Cellular imaging showed its localization primarily in the mitochondria of A549 cancer cells. The JC1 and Annexin-V FITC/PI assays carried out for A549 cancer cells treated with the BODIPY complex showed the alteration of mitochondrial membrane potential and apoptotic cell death on near-IR red light (600-720 nm) irradiation, respectively.
Citations by journals
1
2
3
|
|
Dalton Transactions
|
Dalton Transactions
3 publications, 18.75%
|
Chemistry - An Asian Journal
|
Chemistry - An Asian Journal
2 publications, 12.5%
|
Molecules
|
Molecules
1 publication, 6.25%
|
Journal of Porphyrins and Phthalocyanines
|
Journal of Porphyrins and Phthalocyanines
1 publication, 6.25%
|
Cells
|
Cells
1 publication, 6.25%
|
ACS Applied Bio Materials
|
ACS Applied Bio Materials
1 publication, 6.25%
|
Journal of Inorganic Biochemistry
|
Journal of Inorganic Biochemistry
1 publication, 6.25%
|
Dyes and Pigments
|
Dyes and Pigments
1 publication, 6.25%
|
European Journal of Medicinal Chemistry Reports
|
European Journal of Medicinal Chemistry Reports
1 publication, 6.25%
|
Chinese Chemical Letters
|
Chinese Chemical Letters
1 publication, 6.25%
|
Journal of Materials Chemistry C
|
Journal of Materials Chemistry C
1 publication, 6.25%
|
Sensors & Diagnostics
|
Sensors & Diagnostics
1 publication, 6.25%
|
Journal of Materials Chemistry B
|
Journal of Materials Chemistry B
1 publication, 6.25%
|
1
2
3
|
Citations by publishers
1
2
3
4
5
6
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
6 publications, 37.5%
|
Elsevier
|
Elsevier
4 publications, 25%
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 12.5%
|
Wiley
|
Wiley
2 publications, 12.5%
|
World Scientific
|
World Scientific
1 publication, 6.25%
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
1 publication, 6.25%
|
1
2
3
4
5
6
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[2,7,7],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["12.5","43.75","43.75"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Dalton Transactions","Chemistry - An Asian Journal","Molecules","Journal of Porphyrins and Phthalocyanines","Cells","ACS Applied Bio Materials","Journal of Inorganic Biochemistry","Dyes and Pigments","European Journal of Medicinal Chemistry Reports","Chinese Chemical Letters","Journal of Materials Chemistry C","Sensors & Diagnostics","Journal of Materials Chemistry B"],"ids":[8473,10120,1770,9848,25293,21728,6830,10101,33269,20341,3848,29914,11516],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/jZQkhOOcY9wrGwZm7XGRwMe8H7fThQu3KamISuun_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp"],"datasets":[{"label":"","data":[3,2,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[18.75,12.5,6.25,6.25,6.25,6.25,6.25,6.25,6.25,6.25,6.25,6.25,6.25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Royal Society of Chemistry (RSC)","Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Wiley","World Scientific","American Chemical Society (ACS)"],"ids":[123,17,202,11,23,40],"codes":[0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/jZQkhOOcY9wrGwZm7XGRwMe8H7fThQu3KamISuun_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp"],"datasets":[{"label":"","data":[6,4,2,2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[37.5,25,12.5,12.5,6.25,6.25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Ramu V. et al. Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light. // Inorganic Chemistry. 2021. Vol. 60. No. 9. pp. 6410-6420.
GOST all authors (up to 50)
Copy
Ramu V., Kundu P., Kondaiah P., Chakravarty A. R. Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light. // Inorganic Chemistry. 2021. Vol. 60. No. 9. pp. 6410-6420.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.inorgchem.1c00124
UR - https://doi.org/10.1021%2Facs.inorgchem.1c00124
TI - Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light.
T2 - Inorganic Chemistry
AU - Ramu, Vanitha
AU - Kundu, Paramita
AU - Chakravarty, Akhil R
AU - Kondaiah, Paturu
PY - 2021
DA - 2021/04/12 00:00:00
PB - American Chemical Society (ACS)
SP - 6410-6420
IS - 9
VL - 60
SN - 0020-1669
SN - 1520-510X
ER -
Cite this
BibTex
Copy
@article{2021_Ramu
author = {Vanitha Ramu and Paramita Kundu and Akhil R Chakravarty and Paturu Kondaiah},
title = {Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light.},
journal = {Inorganic Chemistry},
year = {2021},
volume = {60},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021%2Facs.inorgchem.1c00124},
number = {9},
pages = {6410--6420},
doi = {10.1021/acs.inorgchem.1c00124}
}
Cite this
MLA
Copy
Ramu, Vanitha, et al. “Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light..” Inorganic Chemistry, vol. 60, no. 9, Apr. 2021, pp. 6410-6420. https://doi.org/10.1021%2Facs.inorgchem.1c00124.