Inorganic Chemistry, volume 60, issue 9, pages 6410-6420

Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light.

Ramu Vanitha
Kundu Paramita
Kondaiah Paturu
Chakravarty Akhil R
Publication typeJournal Article
Publication date2021-04-12
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor4.6
ISSN00201669, 1520510X
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
Maloplatin-B, a cisplatin-based complex, namely [Pt(A-BOD)(NH3)2](NO3) (Pt-A-BOD) with a pendant boron-dipyrromethene (BODIPY) moiety, where HA-BOD is a methyl malonyl chloride derived monostyryl BODIPY ligand, was designed and developed as near-IR light (600-720 nm) organelle-targeting photodynamic therapy agent. The complex [Pt(acac)(NH3)2](NO3) (Pt-Ac) was used as a control. Pt-A-BOD displayed an absorption band at 616 nm (ε = 2.9 × 104 M-1 cm-1) in 10% dimethyl sulfoxide/Dulbecco's Modified Eagle's Medium (DMSO/DMEM, pH 7.2). This complex displayed a broad emission band within 650-850 nm with a λem value of 720 nm in 10% DMSO-DMEM (pH 7.2) upon excitation (λex) at 615 nm with a large Stokes shift. The fluorescence quantum yield (ΦF) value for Pt-A-BOD is 0.032 and for the ligand HA-BOD is 0.24. The BODIPY complex and ligand showed the formation of singlet oxygen as the ROS (reactive oxygen species) on irradiation with near-IR red light of 660 nm, as evidenced from a 1,3-diphenylisobenzofuran (DPBF) assay. The complex displayed remarkable apoptotic NIR light-induced PDT activity with half-maximum inhibitory concentration values (IC50) of 1.6-2.4 μM in A549 lung and HeLa cervical cancer cells, while it was less active in the dark. The cellular ROS generation by the complex in red light was ascertained by a DCFDA (2',7'-dichlorofluorescein diacetate) assay. Cellular imaging showed its localization primarily in the mitochondria of A549 cancer cells. The JC1 and Annexin-V FITC/PI assays carried out for A549 cancer cells treated with the BODIPY complex showed the alteration of mitochondrial membrane potential and apoptotic cell death on near-IR red light (600-720 nm) irradiation, respectively.

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Ramu V. et al. Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light. // Inorganic Chemistry. 2021. Vol. 60. No. 9. pp. 6410-6420.
GOST all authors (up to 50) Copy
Ramu V., Kundu P., Kondaiah P., Chakravarty A. R. Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light. // Inorganic Chemistry. 2021. Vol. 60. No. 9. pp. 6410-6420.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acs.inorgchem.1c00124
UR - https://doi.org/10.1021%2Facs.inorgchem.1c00124
TI - Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light.
T2 - Inorganic Chemistry
AU - Ramu, Vanitha
AU - Kundu, Paramita
AU - Chakravarty, Akhil R
AU - Kondaiah, Paturu
PY - 2021
DA - 2021/04/12 00:00:00
PB - American Chemical Society (ACS)
SP - 6410-6420
IS - 9
VL - 60
SN - 0020-1669
SN - 1520-510X
ER -
BibTex |
Cite this
BibTex Copy
@article{2021_Ramu
author = {Vanitha Ramu and Paramita Kundu and Akhil R Chakravarty and Paturu Kondaiah},
title = {Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light.},
journal = {Inorganic Chemistry},
year = {2021},
volume = {60},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021%2Facs.inorgchem.1c00124},
number = {9},
pages = {6410--6420},
doi = {10.1021/acs.inorgchem.1c00124}
}
MLA
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Ramu, Vanitha, et al. “Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific "Chemo-PDT" Agent Active in Red Light..” Inorganic Chemistry, vol. 60, no. 9, Apr. 2021, pp. 6410-6420. https://doi.org/10.1021%2Facs.inorgchem.1c00124.
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