Nano Letters, volume 20, issue 10, pages 7536-7542

Physiologically Relevant Mechanics of Biodegradable Polyester Nanoparticles.

Alsharif Nourin 1
Eshaghi Behnaz 2
Reinhard Bjoern 2
Brown Keith 1, 3
1
 
Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, United States
2
 
Department of Chemistry and the Photonics Center, Boston University, Boston, Massachusetts 02215, United States
3
 
Physics Department and Division of Materials Science and Engineering, Boston University, Boston, Massachusetts 02215, United States
Publication typeJournal Article
Publication date2020-09-28
Journal: Nano Letters
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor10.8
ISSN15306984, 15306992
General Chemistry
Condensed Matter Physics
General Materials Science
Mechanical Engineering
Bioengineering
Abstract
Despite the extensive use of biodegradable polyester nanoparticles for drug delivery, and reports of the strong influence of nanoparticle mechanics on nano-bio interactions, there is a lack of systematic studies on the mechanics of these nanoparticles under physiologically relevant conditions. Here, we report indentation experiments on poly(lactic acid) and poly(lactide-co-glycolide) nanoparticles using atomic force microscopy. While dried nanoparticles were found to be rigid at room temperature, their elastic modulus was found to decrease by as much as 30 fold under simulated physiological conditions (i.e., in water at 37 °C). Differential scanning calorimetry confirms that this softening can be attributed to the glass transition of the nanoparticles. Using a combination of mechanical and thermoanalytical characterization, the plasticizing effects of miniaturization, molecular weight, and immersion in water were investigated. Collectively, these experiments provide insight for experimentalists exploring the relationship between polymer nanoparticle mechanics and in vivo behavior.

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GOST Copy
Alsharif N. et al. Physiologically Relevant Mechanics of Biodegradable Polyester Nanoparticles. // Nano Letters. 2020. Vol. 20. No. 10. pp. 7536-7542.
GOST all authors (up to 50) Copy
Alsharif N., Eshaghi B., Reinhard B., Brown K. Physiologically Relevant Mechanics of Biodegradable Polyester Nanoparticles. // Nano Letters. 2020. Vol. 20. No. 10. pp. 7536-7542.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acs.nanolett.0c03004
UR - https://doi.org/10.1021%2Facs.nanolett.0c03004
TI - Physiologically Relevant Mechanics of Biodegradable Polyester Nanoparticles.
T2 - Nano Letters
AU - Alsharif, Nourin
AU - Reinhard, Bjoern
AU - Brown, Keith
AU - Eshaghi, Behnaz
PY - 2020
DA - 2020/09/28 00:00:00
PB - American Chemical Society (ACS)
SP - 7536-7542
IS - 10
VL - 20
PMID - 32986433
SN - 1530-6984
SN - 1530-6992
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Alsharif
author = {Nourin Alsharif and Bjoern Reinhard and Keith Brown and Behnaz Eshaghi},
title = {Physiologically Relevant Mechanics of Biodegradable Polyester Nanoparticles.},
journal = {Nano Letters},
year = {2020},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021%2Facs.nanolett.0c03004},
number = {10},
pages = {7536--7542},
doi = {10.1021/acs.nanolett.0c03004}
}
MLA
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MLA Copy
Alsharif, Nourin, et al. “Physiologically Relevant Mechanics of Biodegradable Polyester Nanoparticles..” Nano Letters, vol. 20, no. 10, Sep. 2020, pp. 7536-7542. https://doi.org/10.1021%2Facs.nanolett.0c03004.
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