ACS Applied Bio Materials, volume 3, issue 9, pages 5845-5855

Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy.

Xie Wensheng ^{1, 2}

Guo Zhenhu ³

Gao Qin ⁴

Wang Dan ¹

Liang Kang ⁵

Gu Zi ⁵

Zhao Lingyun ^{1, 2}

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State Key Laboratory of New Ceramics and Fine Processing, School of materials science and engineering, Tsinghua University, Beijing 100084, China |

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China |

State Key Laboratory of Powder Metallurgy, Powder Metallurgy Research Institute, Central South University, Changsha 410083, China |

⁴

Sinopec Beijing Yanshan Petrochemical Co., Ltd., No. 1 Yanshangang South Road, Fangshan District, Beijing 102500, China |

⁵

School of Chemical Engineering and Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales 2052, Australia |

Publication type: Journal Article

Publication date: 2020-07-16

American Chemical Society (ACS)

Journal: ACS Applied Bio Materials

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Impact factor: 4.6

ISSN: 25766422

DOI: 10.1021/acsabm.0c00564

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General Chemistry

Biomaterials

Biomedical Engineering

Biochemistry (medical)

Abstract

Theranostic nanoplatforms with easy fabrication, high efficiency, and biodegradability are imperative to achieve efficacious and safe cancer treatment outcome. Toward this end, we prepared manganese-doped layered double hydroxide nanoparticles (Mn-LDH NPs) via a facile two-step synthetic method and revealed their excellent photothermal property coupled with simultaneous T1-weighted magnetic resonance imaging enhancement ability. By virtue of these unique properties, imaging-guided photothermal treatment has been achieved to eliminate tumors by using the Mn-LDH NPs without additional photosensitizer, drug, or imaging agent. Specifically, Mn(ox)-LDH NPs (oxidized Mn-LDH NPs) exhibited highly efficient tumor killing ability by activating apoptosis of tumor cells under external NIR 808 nm laser irradiation with the imaging guidance. More importantly, both the MR imaging and in vitro/vivo testing revealed that the Mn-LDH NPs are able to degrade in physiological conditions and demonstrate a high degree of biosafety. Considering the excellent T1-weighted MRI contrast property, effective photothermal performance, biodegradation, and biosafety, the Mn-LDH NPs have presented a potential generation inorganic biodegradable theranostic nanoplatform for efficacious cancer treatment.

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Citations by journals

	1 2
ACS Applied Bio Materials	ACS Applied Bio Materials, 2, 8.33% ACS Applied Bio Materials 2 publications, 8.33%
Chemical Engineering Journal	Chemical Engineering Journal, 2, 8.33% Chemical Engineering Journal 2 publications, 8.33%
Chemical Society Reviews	Chemical Society Reviews, 2, 8.33% Chemical Society Reviews 2 publications, 8.33%
International Journal of Nanomedicine	International Journal of Nanomedicine, 2, 8.33% International Journal of Nanomedicine 2 publications, 8.33%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 4.17% Frontiers in Molecular Biosciences 1 publication, 4.17%
European Physical Journal Plus	European Physical Journal Plus, 1, 4.17% European Physical Journal Plus 1 publication, 4.17%
Journal of the Taiwan Institute of Chemical Engineers	Journal of the Taiwan Institute of Chemical Engineers, 1, 4.17% Journal of the Taiwan Institute of Chemical Engineers 1 publication, 4.17%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 1, 4.17% Advanced Drug Delivery Reviews 1 publication, 4.17%
Journal of Solid State Chemistry	Journal of Solid State Chemistry, 1, 4.17% Journal of Solid State Chemistry 1 publication, 4.17%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 4.17% Journal of Molecular Structure 1 publication, 4.17%
Dyes and Pigments	Dyes and Pigments, 1, 4.17% Dyes and Pigments 1 publication, 4.17%
Advanced NanoBiomed Research	Advanced NanoBiomed Research, 1, 4.17% Advanced NanoBiomed Research 1 publication, 4.17%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 4.17% ACS applied materials & interfaces 1 publication, 4.17%
Biomaterials Science	Biomaterials Science, 1, 4.17% Biomaterials Science 1 publication, 4.17%
CrystEngComm	CrystEngComm, 1, 4.17% CrystEngComm 1 publication, 4.17%
Progress in Materials Science	Progress in Materials Science, 1, 4.17% Progress in Materials Science 1 publication, 4.17%
Nanoscale Horizons	Nanoscale Horizons, 1, 4.17% Nanoscale Horizons 1 publication, 4.17%
Colloids and Surfaces A: Physicochemical and Engineering Aspects	Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1, 4.17% Colloids and Surfaces A: Physicochemical and Engineering Aspects 1 publication, 4.17%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 4.17% Journal of Materials Chemistry B 1 publication, 4.17%
Functionalized Smart Nanomaterials for Point-of-Care Testing	Functionalized Smart Nanomaterials for Point-of-Care Testing, 1, 4.17% Functionalized Smart Nanomaterials for Point-of-Care Testing 1 publication, 4.17%
	1 2

Citations by publishers

	1 2 3 4 5 6 7 8
Elsevier	Elsevier, 8, 33.33% Elsevier 8 publications, 33.33%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 25% Royal Society of Chemistry (RSC) 6 publications, 25%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 12.5% American Chemical Society (ACS) 3 publications, 12.5%
Springer Nature	Springer Nature, 2, 8.33% Springer Nature 2 publications, 8.33%
Dove Medical Press	Dove Medical Press, 2, 8.33% Dove Medical Press 2 publications, 8.33%
Frontiers Media S.A.	Frontiers Media S.A., 1, 4.17% Frontiers Media S.A. 1 publication, 4.17%
Taiwan Institute of Chemical Engineers	Taiwan Institute of Chemical Engineers, 1, 4.17% Taiwan Institute of Chemical Engineers 1 publication, 4.17%
Wiley	Wiley, 1, 4.17% Wiley 1 publication, 4.17%
	1 2 3 4 5 6 7 8

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Xie W. et al. Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy. // ACS Applied Bio Materials. 2020. Vol. 3. No. 9. pp. 5845-5855.

GOST all authors (up to 50) Copy

Xie W., Guo Z., Gao Q., Wang D., Liang K., Gu Z., Zhao L. Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy. // ACS Applied Bio Materials. 2020. Vol. 3. No. 9. pp. 5845-5855.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acsabm.0c00564

UR - https://doi.org/10.1021%2Facsabm.0c00564

TI - Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy.

T2 - ACS Applied Bio Materials

AU - Xie, Wensheng

AU - Liang, Kang

AU - Gu, Zi

AU - Zhao, Lingyun

AU - Guo, Zhenhu

AU - Gao, Qin

AU - Wang, Dan

PY - 2020

DA - 2020/07/16 00:00:00

PB - American Chemical Society (ACS)

SP - 5845-5855

IS - 9

VL - 3

SN - 2576-6422

ER -

BibTex |

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BibTex Copy

@article{2020_Xie,

author = {Wensheng Xie and Kang Liang and Zi Gu and Lingyun Zhao and Zhenhu Guo and Qin Gao and Dan Wang},

title = {Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy.},

journal = {ACS Applied Bio Materials},

year = {2020},

volume = {3},

publisher = {American Chemical Society (ACS)},

month = {jul},

url = {https://doi.org/10.1021%2Facsabm.0c00564},

number = {9},

pages = {5845--5855},

doi = {10.1021/acsabm.0c00564}

}

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Xie, Wensheng, et al. “Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy..” ACS Applied Bio Materials, vol. 3, no. 9, Jul. 2020, pp. 5845-5855. https://doi.org/10.1021%2Facsabm.0c00564.

Found error?

Publisher

American Chemical Society (ACS)

Journal

ACS Applied Bio Materials

Quartile SCImago

Quartile WOS

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Impact factor

4.6

ISSN

25766422 (Electronic)