ACS applied materials & interfaces, volume 8, issue 24, pages 15000-15012

Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells

ZHOU YANHUI 1
YU QIANQIAN 1
Qin Xiuying 1
Bhavsar Dhairya 1
Yang Licong 1
Chen Qingchang 1
Zheng Wenjing 1
Chen Lanmei 1
Liu Jie 1
Publication typeJournal Article
Publication date2015-06-10
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor9.5
ISSN19448244, 19448252
General Materials Science
Abstract
Functionalization can promote the uptake of nanoparticles into cancer cells via receptor-mediated endocytosis, enabling them to exert their therapeutic effects. In this paper, epigallocatechin gallate (EGCG), which has a high binding affinity to 67 kDa laminin receptor (67LR) overexpressed in HCC cells, was employed in the present study to functionalized ruthenium nanoparticles (RuNPs) loaded with luminescent ruthenium complexes to achieve antiliver cancer efficacy. [Ru(bpy)2(4-B)] (ClO4)2·2H2O (RuBB)-loaded EGCG-RuNPs (bpy = 2,2'-bipyridine) showed small particle size with narrow distribution, better stability, and high selectivity between liver cancer and normal cells. The internalization of RuBB-loaded EGCG-RuNPs was inhibited by 67LR-blocking antibody or laminin, suggesting that 67LR-mediated endocytosis played an important role in the uptake into HCC cells. Moreover, transmission electron microscopy and confocal microscopic images showed that RuBB-loaded EGCG-RuNPs accumulated in the cytoplasm of SMMC-7721 cells. Furthermore, our results indicated that the EGCG-functionalized nanoparticles displayed enhanced anticancer effects in a target-specific manner. Concentrations of RuBB-loaded EGCG-RuNPs, nontoxic in normal L-02 cells, showed direct reactive oxygen species-dependent cytotoxic, pro-apoptotic, and anti-invasive effects in SMMC-7721 cells. Furthermore, in vivo animal study demonstrated that RuBB-loaded EGCG-RuNPs possessed high antitumor efficacy on tumor-bearing nude mice. It is encouraging to conclude that the multifunctional RuNPs may form the basis of new strategies on the treatment of liver cancer and other malignancies.

Citations by journals

1
2
OpenNano
OpenNano, 2, 4.65%
OpenNano
2 publications, 4.65%
Drug Delivery
Drug Delivery, 2, 4.65%
Drug Delivery
2 publications, 4.65%
Polyhedron
Polyhedron, 1, 2.33%
Polyhedron
1 publication, 2.33%
Current Drug Delivery
Current Drug Delivery, 1, 2.33%
Current Drug Delivery
1 publication, 2.33%
Nutrients
Nutrients, 1, 2.33%
Nutrients
1 publication, 2.33%
Nanomaterials
Nanomaterials, 1, 2.33%
Nanomaterials
1 publication, 2.33%
Cancers
Cancers, 1, 2.33%
Cancers
1 publication, 2.33%
Frontiers in Pharmacology
Frontiers in Pharmacology, 1, 2.33%
Frontiers in Pharmacology
1 publication, 2.33%
Frontiers in Oncology
Frontiers in Oncology, 1, 2.33%
Frontiers in Oncology
1 publication, 2.33%
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, 1, 2.33%
Frontiers in Bioengineering and Biotechnology
1 publication, 2.33%
Foods
Foods, 1, 2.33%
Foods
1 publication, 2.33%
Nanoscale Research Letters
Nanoscale Research Letters, 1, 2.33%
Nanoscale Research Letters
1 publication, 2.33%
Scientific Reports
Scientific Reports, 1, 2.33%
Scientific Reports
1 publication, 2.33%
Journal of Nanobiotechnology
Journal of Nanobiotechnology, 1, 2.33%
Journal of Nanobiotechnology
1 publication, 2.33%
Acta Pharmacologica Sinica
Acta Pharmacologica Sinica, 1, 2.33%
Acta Pharmacologica Sinica
1 publication, 2.33%
Life Sciences
Life Sciences, 1, 2.33%
Life Sciences
1 publication, 2.33%
Materials Today
Materials Today, 1, 2.33%
Materials Today
1 publication, 2.33%
Materials Science and Engineering C
Materials Science and Engineering C, 1, 2.33%
Materials Science and Engineering C
1 publication, 2.33%
Clinica Chimica Acta
Clinica Chimica Acta, 1, 2.33%
Clinica Chimica Acta
1 publication, 2.33%
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 1, 2.33%
European Journal of Medicinal Chemistry
1 publication, 2.33%
Journal of Functional Foods
Journal of Functional Foods, 1, 2.33%
Journal of Functional Foods
1 publication, 2.33%
Seminars in Cancer Biology
Seminars in Cancer Biology, 1, 2.33%
Seminars in Cancer Biology
1 publication, 2.33%
Coordination Chemistry Reviews
Coordination Chemistry Reviews, 1, 2.33%
Coordination Chemistry Reviews
1 publication, 2.33%
Pharmacological Research
Pharmacological Research, 1, 2.33%
Pharmacological Research
1 publication, 2.33%
Chemistry of Materials
Chemistry of Materials, 1, 2.33%
Chemistry of Materials
1 publication, 2.33%
ACS applied materials & interfaces
ACS applied materials & interfaces, 1, 2.33%
ACS applied materials & interfaces
1 publication, 2.33%
Journal of Materials Chemistry B
Journal of Materials Chemistry B, 1, 2.33%
Journal of Materials Chemistry B
1 publication, 2.33%
Inorganic Chemistry Frontiers
Inorganic Chemistry Frontiers, 1, 2.33%
Inorganic Chemistry Frontiers
1 publication, 2.33%
Chemical Society Reviews
Chemical Society Reviews, 1, 2.33%
Chemical Society Reviews
1 publication, 2.33%
1
2

Citations by publishers

2
4
6
8
10
12
Elsevier
Elsevier, 12, 27.91%
Elsevier
12 publications, 27.91%
Royal Society of Chemistry (RSC)
Royal Society of Chemistry (RSC), 6, 13.95%
Royal Society of Chemistry (RSC)
6 publications, 13.95%
Taylor & Francis
Taylor & Francis, 6, 13.95%
Taylor & Francis
6 publications, 13.95%
Springer Nature
Springer Nature, 5, 11.63%
Springer Nature
5 publications, 11.63%
Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 4, 9.3%
Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 9.3%
Frontiers Media S.A.
Frontiers Media S.A., 3, 6.98%
Frontiers Media S.A.
3 publications, 6.98%
American Chemical Society (ACS)
American Chemical Society (ACS), 2, 4.65%
American Chemical Society (ACS)
2 publications, 4.65%
Bentham Science
Bentham Science, 1, 2.33%
Bentham Science
1 publication, 2.33%
Dove Medical Press
Dove Medical Press, 1, 2.33%
Dove Medical Press
1 publication, 2.33%
King Saud University
King Saud University, 1, 2.33%
King Saud University
1 publication, 2.33%
2
4
6
8
10
12
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
ZHOU Y. et al. Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells // ACS applied materials & interfaces. 2015. Vol. 8. No. 24. pp. 15000-15012.
GOST all authors (up to 50) Copy
ZHOU Y., YU Q., Qin X., Bhavsar D., Yang L., Chen Q., Zheng W., Chen L., Liu J. Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells // ACS applied materials & interfaces. 2015. Vol. 8. No. 24. pp. 15000-15012.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/acsami.5b02261
UR - https://doi.org/10.1021%2Facsami.5b02261
TI - Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells
T2 - ACS applied materials & interfaces
AU - YU, QIANQIAN
AU - Qin, Xiuying
AU - Bhavsar, Dhairya
AU - Yang, Licong
AU - Chen, Qingchang
AU - Zheng, Wenjing
AU - Chen, Lanmei
AU - ZHOU, YANHUI
AU - Liu, Jie
PY - 2015
DA - 2015/06/10 00:00:00
PB - American Chemical Society (ACS)
SP - 15000-15012
IS - 24
VL - 8
SN - 1944-8244
SN - 1944-8252
ER -
BibTex |
Cite this
BibTex Copy
@article{2015_ZHOU
author = {QIANQIAN YU and Xiuying Qin and Dhairya Bhavsar and Licong Yang and Qingchang Chen and Wenjing Zheng and Lanmei Chen and YANHUI ZHOU and Jie Liu},
title = {Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells},
journal = {ACS applied materials & interfaces},
year = {2015},
volume = {8},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021%2Facsami.5b02261},
number = {24},
pages = {15000--15012},
doi = {10.1021/acsami.5b02261}
}
MLA
Cite this
MLA Copy
ZHOU, YANHUI, et al. “Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells.” ACS applied materials & interfaces, vol. 8, no. 24, Jun. 2015, pp. 15000-15012. https://doi.org/10.1021%2Facsami.5b02261.
Found error?