ACS Biomaterials Science and Engineering, volume 6, issue 11, pages 6053-6062
Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles.
1
Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States of America
|
2
Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47906, United States of America
|
Publication type: Journal Article
Publication date: 2020-10-09
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.8
ISSN: 23739878
Biomaterials
Biomedical Engineering
Abstract
Poly(lactic-co-glycolic acid) (PLGA) is the most prevalent polymer drug delivery vehicle in use today. There are about 20 commercialized drug products in which PLGA is used as an excipient. In more than half of these formulations, PLGA is used in the form of microparticles (with sizes in the range between 60 nm and 100 μm). The primary role of PLGA is to control the kinetics of drug release toward achieving sustained release of the drug. Unfortunately, most drug-loaded PLGA microparticles exhibit a common drawback: an initial uncontrolled burst of the drug. After 30 years of utilization of PLGA in controlled drug delivery systems, this initial burst drug release still remains an unresolved challenge. In this Review, we present a summary of the proposed mechanisms responsible for this phenomenon and the known factors affecting the burst release process. Also, we discuss examples of recent efforts made to reduce the initial burst release of the drug from PLGA particles.
Citations by journals
|
2
4
6
8
10
12
14
16
18
|
|
|
Pharmaceutics
|
Pharmaceutics
17 publications, 9.6%
|
|
International Journal of Pharmaceutics
|
International Journal of Pharmaceutics
12 publications, 6.78%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
6 publications, 3.39%
|
|
International Journal of Biological Macromolecules
|
International Journal of Biological Macromolecules
6 publications, 3.39%
|
|
Polymers
|
Polymers
5 publications, 2.82%
|
|
Carbohydrate Polymers
|
Carbohydrate Polymers
5 publications, 2.82%
|
|
ACS Applied Bio Materials
|
ACS Applied Bio Materials
4 publications, 2.26%
|
|
European Journal of Pharmaceutical Sciences
|
European Journal of Pharmaceutical Sciences
4 publications, 2.26%
|
|
Journal of Drug Delivery Science and Technology
|
Journal of Drug Delivery Science and Technology
4 publications, 2.26%
|
|
Journal of Controlled Release
|
Journal of Controlled Release
4 publications, 2.26%
|
|
Journal of Nanobiotechnology
|
Journal of Nanobiotechnology
3 publications, 1.69%
|
|
ACS Omega
|
ACS Omega
3 publications, 1.69%
|
|
European Journal of Pharmaceutics and Biopharmaceutics
|
European Journal of Pharmaceutics and Biopharmaceutics
3 publications, 1.69%
|
|
International Journal of Nanomedicine
|
International Journal of Nanomedicine
3 publications, 1.69%
|
|
Molecules
|
Molecules
2 publications, 1.13%
|
|
Gels
|
Gels
2 publications, 1.13%
|
|
Frontiers in Immunology
|
Frontiers in Immunology
2 publications, 1.13%
|
|
Nature Communications
|
Nature Communications
2 publications, 1.13%
|
|
Ceramics International
|
Ceramics International
2 publications, 1.13%
|
|
Biomaterials Advances
|
Biomaterials Advances
2 publications, 1.13%
|
|
Journal of Pharmaceutical Sciences
|
Journal of Pharmaceutical Sciences
2 publications, 1.13%
|
|
Advanced healthcare materials
|
Advanced healthcare materials
2 publications, 1.13%
|
|
ACS Macro Letters
|
ACS Macro Letters
2 publications, 1.13%
|
|
Biomedical Materials (Bristol)
|
Biomedical Materials (Bristol)
2 publications, 1.13%
|
|
Molecular Pharmaceutics
|
Molecular Pharmaceutics
2 publications, 1.13%
|
|
Antioxidants
|
Antioxidants
1 publication, 0.56%
|
|
Russian Journal of Physical Chemistry B
|
Russian Journal of Physical Chemistry B
1 publication, 0.56%
|
|
Beilstein Journal of Nanotechnology
|
Beilstein Journal of Nanotechnology
1 publication, 0.56%
|
|
Drug Development and Industrial Pharmacy
|
Drug Development and Industrial Pharmacy
1 publication, 0.56%
|
|
2
4
6
8
10
12
14
16
18
|
Citations by publishers
|
10
20
30
40
50
60
|
|
|
Elsevier
|
Elsevier
60 publications, 33.9%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
42 publications, 23.73%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
17 publications, 9.6%
|
|
Springer Nature
|
Springer Nature
14 publications, 7.91%
|
|
Wiley
|
Wiley
9 publications, 5.08%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
8 publications, 4.52%
|
|
Taylor & Francis
|
Taylor & Francis
4 publications, 2.26%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
4 publications, 2.26%
|
|
Dove Medical Press
|
Dove Medical Press
3 publications, 1.69%
|
|
IOP Publishing
|
IOP Publishing
2 publications, 1.13%
|
|
Bentham Science
|
Bentham Science
2 publications, 1.13%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 0.56%
|
|
Beilstein-Institut
|
Beilstein-Institut
1 publication, 0.56%
|
|
Pharmaceutical Society of Korea
|
Pharmaceutical Society of Korea
1 publication, 0.56%
|
|
Korean Society of Industrial Engineering Chemistry
|
Korean Society of Industrial Engineering Chemistry, 1, 0.56%
Korean Society of Industrial Engineering Chemistry
1 publication, 0.56%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
1 publication, 0.56%
|
|
Hindawi Limited
|
Hindawi Limited
1 publication, 0.56%
|
|
Begell House
|
Begell House
1 publication, 0.56%
|
|
The Korean Fiber Society
|
The Korean Fiber Society
1 publication, 0.56%
|
|
10
20
30
40
50
60
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[2,24,55,71,25],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["1.13","13.56","31.07","40.11","14.12"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Pharmaceutics","International Journal of Pharmaceutics","International Journal of Molecular Sciences","International Journal of Biological Macromolecules","Polymers","Carbohydrate Polymers","ACS Applied Bio Materials","European Journal of Pharmaceutical Sciences","Journal of Drug Delivery Science and Technology","Journal of Controlled Release","Journal of Nanobiotechnology","ACS Omega","European Journal of Pharmaceutics and Biopharmaceutics","International Journal of Nanomedicine","Molecules","Gels","Frontiers in Immunology","Nature Communications","Ceramics International","Biomaterials Advances","Journal of Pharmaceutical Sciences","Advanced healthcare materials","ACS Macro Letters","Biomedical Materials (Bristol)","Molecular Pharmaceutics","Antioxidants","Russian Journal of Physical Chemistry B","Beilstein Journal of Nanotechnology","Drug Development and Industrial Pharmacy"],"ids":[4502,3305,14627,23035,11204,11946,21728,9338,17907,14351,11794,18901,25165,10956,1770,16915,1699,3231,15103,27992,7218,21975,957,13063,19735,16381,16359,24250,24331],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/ex6KJoZujZOZFZh7jGfeHauiftuB3CI7iwJVFRDg_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp"],"datasets":[{"label":"","data":[17,12,6,6,5,5,4,4,4,4,3,3,3,3,2,2,2,2,2,2,2,2,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[9.6,6.78,3.39,3.39,2.82,2.82,2.26,2.26,2.26,2.26,1.69,1.69,1.69,1.69,1.13,1.13,1.13,1.13,1.13,1.13,1.13,1.13,1.13,1.13,1.13,0.56,0.56,0.56,0.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","American Chemical Society (ACS)","Springer Nature","Wiley","Royal Society of Chemistry (RSC)","Taylor & Francis","Frontiers Media S.A.","Dove Medical Press","IOP Publishing","Bentham Science","Pleiades Publishing","Beilstein-Institut","Pharmaceutical Society of Korea","Korean Society of Industrial Engineering Chemistry","Public Library of Science (PLoS)","Hindawi Limited","Begell House","The Korean Fiber Society"],"ids":[17,202,40,8,11,123,18,208,417,2075,39,101,6139,8825,709,344,6921,93,7431],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/ex6KJoZujZOZFZh7jGfeHauiftuB3CI7iwJVFRDg_medium.webp","\/storage\/images\/resized\/orXcZtXpI7UpnWWqQEfW5ZNVoteL6CqvOi1ztUcD_medium.webp","","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/PuQOXgokguLFai08NXV6ys8UB0t2UiK3jku1V7aj_medium.webp","\/storage\/images\/resized\/0hTYLrwJ8rHnOcrTj7DxlPdgL8G6CfN3h3QElPp5_medium.webp"],"datasets":[{"label":"","data":[60,42,17,14,9,8,4,4,3,2,2,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.9,23.73,9.6,7.91,5.08,4.52,2.26,2.26,1.69,1.13,1.13,0.56,0.56,0.56,0.56,0.56,0.56,0.56,0.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Yoo J., Won Y. S. Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles. // ACS Biomaterials Science and Engineering. 2020. Vol. 6. No. 11. pp. 6053-6062.
GOST all authors (up to 50)
Copy
Yoo J., Won Y. S. Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles. // ACS Biomaterials Science and Engineering. 2020. Vol. 6. No. 11. pp. 6053-6062.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsbiomaterials.0c01228
UR - https://doi.org/10.1021%2Facsbiomaterials.0c01228
TI - Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles.
T2 - ACS Biomaterials Science and Engineering
AU - Won, You Sun
AU - Yoo, Jin
PY - 2020
DA - 2020/10/09 00:00:00
PB - American Chemical Society (ACS)
SP - 6053-6062
IS - 11
VL - 6
SN - 2373-9878
ER -
Cite this
BibTex
Copy
@article{2020_Yoo,
author = {You Sun Won and Jin Yoo},
title = {Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles.},
journal = {ACS Biomaterials Science and Engineering},
year = {2020},
volume = {6},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021%2Facsbiomaterials.0c01228},
number = {11},
pages = {6053--6062},
doi = {10.1021/acsbiomaterials.0c01228}
}
Cite this
MLA
Copy
Yoo, Jin, et al. “Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles..” ACS Biomaterials Science and Engineering, vol. 6, no. 11, Oct. 2020, pp. 6053-6062. https://doi.org/10.1021%2Facsbiomaterials.0c01228.