Journal of the American Chemical Society, volume 142, issue 26, pages 11442-11450

Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer.

Feng Haitao ^{1, 2}

Zou Shaomin

Chen Ming ²

Xiong Feng ³

Lee Mong-Hong

Fang Lekun

Wang Dong ^{2, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Baoji AIE Research Center, Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China |

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, Institute for Advanced Study, Department of Chemical and Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, and Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China |

Shenzhen Jinyu Biotechnology Co., Ltd., B1203 Compass Life Science Park, Julongshan B Road, Shenzhen 518118, China |

⁴

State Key Laboratory of Luminescent Materials and Devices, Center for Aggregation-induced emission, South China University of Technology, Guangzhou 510640, China |

Publication type: Journal Article

Publication date: 2020-06-01

American Chemical Society (ACS)

Journal: Journal of the American Chemical Society

Quartile SCImago

Quartile WOS

Impact factor: 15

ISSN: 00027863, 15205126

DOI: 10.1021/jacs.0c02434

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General Chemistry

Catalysis

Biochemistry

Colloid and Surface Chemistry

Abstract

Colon cancer is one of the most common cancers with high mortality in humans. Early diagnosis and treatment of colon cancer is of great significance for cancer therapy. Up until now, numerous theranostic agents have been developed to detect and kill cancer cells. However, few reports have focused on how these agents control and affect gene expression of cancer cells in vivo. Herein, three pyridinium-functionalized tetraphenylethylene derivatives (namely TPE-OM, TPE-H and TPE-NO2) with electron-donating and electron-withdrawing groups were facilely synthesized as theranostic agents for cell imaging and anti-colon cancer therapy. Among these AIE luminogens (AIEgens), TPE-OM with donor and acceptor structure showed the best treatment efficacy for colon cancer through systematic biological evaluation and comparison. Both in vitro cell imaging and in vivo tumor treatment experiments demonstrated that TPE-OM can be utilized as an efficient theranostic agent to diagnose and kill colon cancer cells. Flow cytometric analysis revealed that cell cycle process was disturbed by TPE-OM in colon cancer cells. Deep insight into the gene level revealed that the expressions of cell cycle-promoting genes were inhibited upon addition of TPE-OM. This study may open a new venue for unraveling the mechanisms of cancer metastasis.

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Citations by journals

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Chemical Engineering Journal	Chemical Engineering Journal, 3, 4.84% Chemical Engineering Journal 3 publications, 4.84%
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Advanced healthcare materials	Advanced healthcare materials, 3, 4.84% Advanced healthcare materials 3 publications, 4.84%
Chemical Research in Chinese Universities	Chemical Research in Chinese Universities, 2, 3.23% Chemical Research in Chinese Universities 2 publications, 3.23%
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 2, 3.23% Coordination Chemistry Reviews 2 publications, 3.23%
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Chinese Chemical Letters	Chinese Chemical Letters, 2, 3.23% Chinese Chemical Letters 2 publications, 3.23%
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Chemical Communications	Chemical Communications, 2, 3.23% Chemical Communications 2 publications, 3.23%
RSC Chemical Biology	RSC Chemical Biology, 2, 3.23% RSC Chemical Biology 2 publications, 3.23%
ACS Applied Bio Materials	ACS Applied Bio Materials, 1, 1.61% ACS Applied Bio Materials 1 publication, 1.61%
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Frontiers in Chemistry	Frontiers in Chemistry, 1, 1.61% Frontiers in Chemistry 1 publication, 1.61%
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Materials and Design	Materials and Design, 1, 1.61% Materials and Design 1 publication, 1.61%
ACS Applied Nano Materials	ACS Applied Nano Materials, 1, 1.61% ACS Applied Nano Materials 1 publication, 1.61%
Pharmacological Research	Pharmacological Research, 1, 1.61% Pharmacological Research 1 publication, 1.61%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 1, 1.61% International Journal of Pharmaceutics 1 publication, 1.61%
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1, 1.61% Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 1 publication, 1.61%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 1.61% International Journal of Biological Macromolecules 1 publication, 1.61%
Analytica Chimica Acta	Analytica Chimica Acta, 1, 1.61% Analytica Chimica Acta 1 publication, 1.61%
Materials Science and Engineering: R: Reports	Materials Science and Engineering: R: Reports, 1, 1.61% Materials Science and Engineering: R: Reports 1 publication, 1.61%
Advanced Functional Materials	Advanced Functional Materials, 1, 1.61% Advanced Functional Materials 1 publication, 1.61%
Angewandte Chemie	Angewandte Chemie, 1, 1.61% Angewandte Chemie 1 publication, 1.61%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 1.61% Angewandte Chemie - International Edition 1 publication, 1.61%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 1.61% Chemistry - A European Journal 1 publication, 1.61%
Small	Small, 1, 1.61% Small 1 publication, 1.61%
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Citations by publishers

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Elsevier	Elsevier, 19, 30.65% Elsevier 19 publications, 30.65%
Wiley	Wiley, 13, 20.97% Wiley 13 publications, 20.97%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 13, 20.97% Royal Society of Chemistry (RSC) 13 publications, 20.97%
American Chemical Society (ACS)	American Chemical Society (ACS), 7, 11.29% American Chemical Society (ACS) 7 publications, 11.29%
Springer Nature	Springer Nature, 5, 8.06% Springer Nature 5 publications, 8.06%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 4.84% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 4.84%
Frontiers Media S.A.	Frontiers Media S.A., 2, 3.23% Frontiers Media S.A. 2 publications, 3.23%
	2 4 6 8 10 12 14 16 18 20

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Feng H. et al. Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer. // Journal of the American Chemical Society. 2020. Vol. 142. No. 26. pp. 11442-11450.

GOST all authors (up to 50) Copy

Feng H., Zou S., Chen M., Xiong F., Lee M., Fang L., Wang D. Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer. // Journal of the American Chemical Society. 2020. Vol. 142. No. 26. pp. 11442-11450.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/jacs.0c02434

UR - https://doi.org/10.1021%2Fjacs.0c02434

TI - Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer.

T2 - Journal of the American Chemical Society

AU - Fang, Lekun

AU - Feng, Haitao

AU - Chen, Ming

AU - Xiong, Feng

AU - Wang, Dong

AU - Zou, Shaomin

AU - Lee, Mong-Hong

PY - 2020

DA - 2020/06/01 00:00:00

PB - American Chemical Society (ACS)

SP - 11442-11450

IS - 26

VL - 142

SN - 0002-7863

SN - 1520-5126

ER -

BibTex |

Cite this

BibTex Copy

@article{2020_Feng,

author = {Lekun Fang and Haitao Feng and Ming Chen and Feng Xiong and Dong Wang and Shaomin Zou and Mong-Hong Lee},

title = {Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer.},

journal = {Journal of the American Chemical Society},

year = {2020},

volume = {142},

publisher = {American Chemical Society (ACS)},

month = {jun},

url = {https://doi.org/10.1021%2Fjacs.0c02434},

number = {26},

pages = {11442--11450},

doi = {10.1021/jacs.0c02434}

}

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MLA Copy

Feng, Haitao, et al. “Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer..” Journal of the American Chemical Society, vol. 142, no. 26, Jun. 2020, pp. 11442-11450. https://doi.org/10.1021%2Fjacs.0c02434.

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Publisher

American Chemical Society (ACS)

Journal

Journal of the American Chemical Society

Quartile SCImago

Quartile WOS

Impact factor

ISSN

00027863 (Print)
15205126 (Electronic)