Journal of Medicinal Chemistry, volume 52, issue 14, pages 4380-4390
Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships
Ermoli Antonella
1
,
Bargiotti Alberto
1
,
Brasca Maria Gabriella
1
,
Ciavolella Antonella
1
,
Colombo Nicoletta
1
,
Fachin Gabriele
1
,
Isacchi Antonella
1
,
Menichincheri Maria
1
,
MOLINARI Antonio
1
,
Montagnoli Alessia
1
,
Pillan Antonio
1
,
Rainoldi Sonia
1
,
Sirtori Federico Riccardi
1
,
SOLA FRANCESCO
1
,
Thieffine Sandrine
1
,
Tibolla Marcellino
1
,
VALSASINA Barbara
1
,
Volpi Daniele
1
,
Santocanale Corrado
1
,
Vanotti Ermes
1
1
Nerviano Medical Sciences, Srl viale Pasteur 10, 20014 Nerviano, Milano, Italy
|
Publication type: Journal Article
Publication date: 2009-06-25
Journal:
Journal of Medicinal Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.3
ISSN: 00222623, 15204804
Drug Discovery
Molecular Medicine
Abstract
Cdc7 kinase has recently emerged as an attractive target for cancer therapy and low-molecular-weight inhibitors of Cdc7 kinase have been found to be effective in the inhibition of tumor growth in animal models. In this paper, we describe synthesis and structure−activity relationships of new 1H-pyrrolo[2,3-b]pyridine derivatives identified as inhibitors of Cdc7 kinase. Progress from (Z)-2-phenyl-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-3,5-dihydro-4H-imidazol-4-one (1) to [(Z)-2-(benzylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-1,3-thiazol-4(5H)-one] (42), a potent ATP mimetic inhibitor of Cdc7 kinase with IC50 value of 7 nM, is also reported.
Citations by journals
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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1 publication, 2.13%
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International Journal of Pharmacology, 1, 2.13%
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1 publication, 2.13%
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7
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Citations by publishers
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5
10
15
20
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Elsevier
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Elsevier
20 publications, 42.55%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
9 publications, 19.15%
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Wiley
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4 publications, 8.51%
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Springer Nature
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Springer Nature
3 publications, 6.38%
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Royal Society of Chemistry (RSC)
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2 publications, 4.26%
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1 publication, 2.13%
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1 publication, 2.13%
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Public Library of Science (PLoS)
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1 publication, 2.13%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 2.13%
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Science Alert
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Science Alert, 1, 2.13%
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1 publication, 2.13%
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American Association for Cancer Research (AACR)
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American Association for Cancer Research (AACR)
1 publication, 2.13%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 2.13%
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Thieme
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Thieme
1 publication, 2.13%
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Taylor & Francis
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Taylor & Francis
1 publication, 2.13%
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5
10
15
20
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Ermoli A. et al. Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships // Journal of Medicinal Chemistry. 2009. Vol. 52. No. 14. pp. 4380-4390.
GOST all authors (up to 50)
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Ermoli A., Bargiotti A., Brasca M. G., Ciavolella A., Colombo N., Fachin G., Isacchi A., Menichincheri M., MOLINARI A., Montagnoli A., Pillan A., Rainoldi S., Sirtori F. R., SOLA F., Thieffine S., Tibolla M., VALSASINA B., Volpi D., Santocanale C., Vanotti E. Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships // Journal of Medicinal Chemistry. 2009. Vol. 52. No. 14. pp. 4380-4390.
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TY - JOUR
DO - 10.1021/jm900248g
UR - https://doi.org/10.1021%2Fjm900248g
TI - Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships
T2 - Journal of Medicinal Chemistry
AU - Ermoli, Antonella
AU - Bargiotti, Alberto
AU - Brasca, Maria Gabriella
AU - Ciavolella, Antonella
AU - Colombo, Nicoletta
AU - Fachin, Gabriele
AU - Isacchi, Antonella
AU - Menichincheri, Maria
AU - MOLINARI, Antonio
AU - Montagnoli, Alessia
AU - Pillan, Antonio
AU - Rainoldi, Sonia
AU - Sirtori, Federico Riccardi
AU - SOLA, FRANCESCO
AU - Thieffine, Sandrine
AU - Tibolla, Marcellino
AU - VALSASINA, Barbara
AU - Volpi, Daniele
AU - Vanotti, Ermes
AU - Santocanale, Corrado
PY - 2009
DA - 2009/06/25 00:00:00
PB - American Chemical Society (ACS)
SP - 4380-4390
IS - 14
VL - 52
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2009_Ermoli,
author = {Antonella Ermoli and Alberto Bargiotti and Maria Gabriella Brasca and Antonella Ciavolella and Nicoletta Colombo and Gabriele Fachin and Antonella Isacchi and Maria Menichincheri and Antonio MOLINARI and Alessia Montagnoli and Antonio Pillan and Sonia Rainoldi and Federico Riccardi Sirtori and FRANCESCO SOLA and Sandrine Thieffine and Marcellino Tibolla and Barbara VALSASINA and Daniele Volpi and Ermes Vanotti and Corrado Santocanale},
title = {Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships},
journal = {Journal of Medicinal Chemistry},
year = {2009},
volume = {52},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021%2Fjm900248g},
number = {14},
pages = {4380--4390},
doi = {10.1021/jm900248g}
}
Cite this
MLA
Copy
Ermoli, Antonella, et al. “Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships.” Journal of Medicinal Chemistry, vol. 52, no. 14, Jun. 2009, pp. 4380-4390. https://doi.org/10.1021%2Fjm900248g.