Journal of Organic Chemistry, volume 77, issue 2, pages 1181-1185
Titration of nonstabilized diazoalkane solutions by fluorine NMR.
1
Department of Chemistry,
Eugene F. Merkert Chemistry
Center, Boston College, Chestnut Hill,
Massachusetts 02467, United States
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Publication type: Journal Article
Publication date: 2012-01-11
Journal:
Journal of Organic Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 3.6
ISSN: 00223263, 15206904
Organic Chemistry
Abstract
A new protocol for titrating nonstabilized diazoalkane solutions by quantitative (19)F NMR is reported. An excess of 2-fluorobenzoic acid dissolved in CDCl(3) is treated with the diazoalkane solution at a low temperature, immediately forming the corresponding 2-fluorobenzoate ester upon warming. A significant difference in the (19)F chemical shift between the ester and acid is seen, allowing facile and accurate integration to determine titer. The procedure is safe, rapid, and indicates the active diazoalkane concentration with high precision.
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Citations by publishers
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1
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3
4
5
6
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American Chemical Society (ACS)
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6 publications, 33.33%
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Wiley
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Wiley
4 publications, 22.22%
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Elsevier
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3 publications, 16.67%
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Royal Society of Chemistry (RSC)
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3 publications, 16.67%
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Thieme
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Thieme
1 publication, 5.56%
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Springer Nature
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Springer Nature
1 publication, 5.56%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Rendina V. L., Kingsbury J. S. Titration of nonstabilized diazoalkane solutions by fluorine NMR. // Journal of Organic Chemistry. 2012. Vol. 77. No. 2. pp. 1181-1185.
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Rendina V. L., Kingsbury J. S. Titration of nonstabilized diazoalkane solutions by fluorine NMR. // Journal of Organic Chemistry. 2012. Vol. 77. No. 2. pp. 1181-1185.
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TY - JOUR
DO - 10.1021/jo202214e
UR - https://doi.org/10.1021%2Fjo202214e
TI - Titration of nonstabilized diazoalkane solutions by fluorine NMR.
T2 - Journal of Organic Chemistry
AU - Rendina, Victor L
AU - Kingsbury, Jason S
PY - 2012
DA - 2012/01/11 00:00:00
PB - American Chemical Society (ACS)
SP - 1181-1185
IS - 2
VL - 77
SN - 0022-3263
SN - 1520-6904
ER -
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@article{2012_Rendina,
author = {Victor L Rendina and Jason S Kingsbury},
title = {Titration of nonstabilized diazoalkane solutions by fluorine NMR.},
journal = {Journal of Organic Chemistry},
year = {2012},
volume = {77},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021%2Fjo202214e},
number = {2},
pages = {1181--1185},
doi = {10.1021/jo202214e}
}
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Rendina, Victor L., and Jason S Kingsbury. “Titration of nonstabilized diazoalkane solutions by fluorine NMR..” Journal of Organic Chemistry, vol. 77, no. 2, Jan. 2012, pp. 1181-1185. https://doi.org/10.1021%2Fjo202214e.