ACS Medicinal Chemistry Letters, volume 6, issue 3, pages 271-275

Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis

Ferreira Soraya Z 1
Carneiro Hellem C. 1
Lara Hugo A 1
Alves Rosemeire B. 1
Resende Jarbas 1
Oliveira Heloísa M 2
Silva Luciana M. 2
Santos Daniel 1
Freitas Rossimiriam 1
1
 
Departamento de Química, Instituto de Ciências Exatas, and Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.
2
 
Serviço de Biologia Celular, Diretoria de Pesquisa e Desenvolvimento da Fundação Ezequiel Dias, Belo Horizonte, Brazil
Publication typeJournal Article
Publication date2015-01-12
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor4.2
ISSN19485875
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Antimicrobial peptides (AMPs) are currently being investigated as potential sources of novel therapeutics against an increasing number of microorganisms resistant to conventional antibiotics. The conjugation of an AMP to other bioactive compounds is an interesting approach for the development of new derivatives with increased antimicrobial efficiency and broader spectra of action. In this work, the synthesis of a new peptide-coumarin conjugate via copper(I)-catalyzed azide-alkyne cycloaddition is described. The conjugate was assayed for in vitro cytotoxicity and displayed antifungal activity against Cryptococcus gattii and Cryptococcus neoformans. Additionally, the conjugate exhibited increased antifungal efficacy when compared with the individual peptide, coumarin, or triazole moieties. Treatment of C. gattii with the peptide-coumarin conjugate enhanced the production of reactive oxygen species, suggesting that the oxidative burst plays an important role in the mechanism of action of the conjugate.

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GOST Copy
Ferreira S. Z. et al. Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis // ACS Medicinal Chemistry Letters. 2015. Vol. 6. No. 3. pp. 271-275.
GOST all authors (up to 50) Copy
Ferreira S. Z., Carneiro H. C., Lara H. A., Alves R. B., Resende J., Oliveira H. M., Silva L. M., Santos D., Freitas R. Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis // ACS Medicinal Chemistry Letters. 2015. Vol. 6. No. 3. pp. 271-275.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/ml500393q
UR - https://doi.org/10.1021%2Fml500393q
TI - Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis
T2 - ACS Medicinal Chemistry Letters
AU - Ferreira, Soraya Z
AU - Carneiro, Hellem C.
AU - Lara, Hugo A
AU - Oliveira, Heloísa M
AU - Silva, Luciana M.
AU - Alves, Rosemeire B.
AU - Resende, Jarbas
AU - Santos, Daniel
AU - Freitas, Rossimiriam
PY - 2015
DA - 2015/01/12 00:00:00
PB - American Chemical Society (ACS)
SP - 271-275
IS - 3
VL - 6
SN - 1948-5875
ER -
BibTex |
Cite this
BibTex Copy
@article{2015_Ferreira
author = {Soraya Z Ferreira and Hellem C. Carneiro and Hugo A Lara and Heloísa M Oliveira and Luciana M. Silva and Rosemeire B. Alves and Jarbas Resende and Daniel Santos and Rossimiriam Freitas},
title = {Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis},
journal = {ACS Medicinal Chemistry Letters},
year = {2015},
volume = {6},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021%2Fml500393q},
number = {3},
pages = {271--275},
doi = {10.1021/ml500393q}
}
MLA
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MLA Copy
Ferreira, Soraya Z., et al. “Synthesis of a New Peptide–Coumarin Conjugate: A Potential Agent against Cryptococcosis.” ACS Medicinal Chemistry Letters, vol. 6, no. 3, Jan. 2015, pp. 271-275. https://doi.org/10.1021%2Fml500393q.
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