Organometallics, volume 33, issue 5, pages 1100-1103
Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes
Peña Bruno
1
,
David Amanda
1
,
Pavani Christiane
2
,
Baptista Mauricio S.
2
,
Wang Ting-Yi
3
,
Turro Claudia
4
,
1
Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842-3012, United States
|
2
Department
of Biochemistry, University of São Paulo, São Paulo 05508-070, Brazil
|
3
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, United States
|
4
Department
of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210-1340, United States
|
Publication type: Journal Article
Publication date: 2014-02-18
Journal:
Organometallics
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 2.8
ISSN: 02767333, 15206041
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
The antiproliferative activity of four Ru(II) dyes incorporating the cyclometallated ligand phpy– (deprotonated 2-phenylpyridine) have been tested against HeLa cells. All of the compounds exhibit cytotoxic activity similar to that of cisplatin. The most active compound, [Ru(phpy)(bpy)(dppn)]+ (4; bpy = 2,2′-bipyridine, dppn = benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine), is 6 times more active than the platinum drug, and it is able to disrupt the mitochondria membrane potential. In addition, [Ru(phpy)(biq)2]+ (3; biq = 2,2′-biqinoline), with strong absorption at 640 nm, exhibits enhanced activity upon irradiation with 633 nm light. These findings demonstrate that coordinatively saturated cyclometallated Ru dyes have the potential to emerge as a new family of organometallic anticancer compounds, both in the dark and upon irradiation with low-energy light. The compound [Ru(phpy)(pap)(NCCH3)2]+ (5; pap = 2-(phenylazo)pyridine) was also synthesized and structurally characterized as a new precursor for the prepar...
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Peña B. et al. Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes // Organometallics. 2014. Vol. 33. No. 5. pp. 1100-1103.
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Peña B., David A., Pavani C., Baptista M. S., Wang T., Turro C., Dunbar K. Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes // Organometallics. 2014. Vol. 33. No. 5. pp. 1100-1103.
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TY - JOUR
DO - 10.1021/om500001h
UR - https://doi.org/10.1021%2Fom500001h
TI - Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes
T2 - Organometallics
AU - Peña, Bruno
AU - David, Amanda
AU - Pavani, Christiane
AU - Baptista, Mauricio S.
AU - Wang, Ting-Yi
AU - Turro, Claudia
AU - Dunbar, Kim
PY - 2014
DA - 2014/02/18 00:00:00
PB - American Chemical Society (ACS)
SP - 1100-1103
IS - 5
VL - 33
SN - 0276-7333
SN - 1520-6041
ER -
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@article{2014_Peña,
author = {Bruno Peña and Amanda David and Christiane Pavani and Mauricio S. Baptista and Ting-Yi Wang and Claudia Turro and Kim Dunbar},
title = {Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes},
journal = {Organometallics},
year = {2014},
volume = {33},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021%2Fom500001h},
number = {5},
pages = {1100--1103},
doi = {10.1021/om500001h}
}
Cite this
MLA
Copy
Peña, Bruno, et al. “Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes.” Organometallics, vol. 33, no. 5, Feb. 2014, pp. 1100-1103. https://doi.org/10.1021%2Fom500001h.