Nature, volume 362, issue 6422, pages 709-715

Instability and decay of the primary structure of DNA

Lindahl Tomas 1
1
 
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms. Hertfordshire, UK
Publication typeJournal Article
Publication date1993-04-01
Journal: Nature
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor64.8
ISSN00280836, 14764687
Multidisciplinary
Abstract
Although DNA is the carrier of genetic information, it has limited chemical stability. Hydrolysis, oxidation and nonenzymatic methylation of DNA occur at significant ratesin vivo, and are counteracted by specific DNA repair processes. The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.

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GOST |
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GOST Copy
Lindahl T. Instability and decay of the primary structure of DNA // Nature. 1993. Vol. 362. No. 6422. pp. 709-715.
GOST all authors (up to 50) Copy
Lindahl T. Instability and decay of the primary structure of DNA // Nature. 1993. Vol. 362. No. 6422. pp. 709-715.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/362709a0
UR - https://doi.org/10.1038%2F362709a0
TI - Instability and decay of the primary structure of DNA
T2 - Nature
AU - Lindahl, Tomas
PY - 1993
DA - 1993/04/01 00:00:00
PB - Springer Nature
SP - 709-715
IS - 6422
VL - 362
SN - 0028-0836
SN - 1476-4687
ER -
BibTex |
Cite this
BibTex Copy
@article{1993_Lindahl
author = {Tomas Lindahl},
title = {Instability and decay of the primary structure of DNA},
journal = {Nature},
year = {1993},
volume = {362},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1038%2F362709a0},
number = {6422},
pages = {709--715},
doi = {10.1038/362709a0}
}
MLA
Cite this
MLA Copy
Lindahl, Tomas. “Instability and decay of the primary structure of DNA.” Nature, vol. 362, no. 6422, Apr. 1993, pp. 709-715. https://doi.org/10.1038%2F362709a0.
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