Nature, volume 455, issue 7213, pages 633-637
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
1
Gene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA ,
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Publication type: Journal Article
Publication date: 2008-08-31
Multidisciplinary
Abstract
A common hallmark of human cancers is the overexpression of telomerase, a ribonucleoprotein complex that is responsible for maintaining the length and integrity of chromosome ends. Telomere length deregulation and telomerase activation is an early, and perhaps necessary, step in cancer cell evolution. Here we present the high-resolution structure of the Tribolium castaneum catalytic subunit of telomerase, TERT. The protein consists of three highly conserved domains, organized into a ring-like structure that shares common features with retroviral reverse transcriptases, viral RNA polymerases and B-family DNA polymerases. Domain organization places motifs implicated in substrate binding and catalysis in the interior of the ring, which can accommodate seven to eight bases of double-stranded nucleic acid. Modelling of an RNA–DNA heteroduplex in the interior of this ring demonstrates a perfect fit between the protein and the nucleic acid substrate, and positions the 3′-end of the DNA primer at the active site of the enzyme, providing evidence for the formation of an active telomerase elongation complex.
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Gillis A. J., Schuller A. P., Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT // Nature. 2008. Vol. 455. No. 7213. pp. 633-637.
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Gillis A. J., Schuller A. P., Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT // Nature. 2008. Vol. 455. No. 7213. pp. 633-637.
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TY - JOUR
DO - 10.1038/nature07283
UR - https://doi.org/10.1038%2Fnature07283
TI - Structure of the Tribolium castaneum telomerase catalytic subunit TERT
T2 - Nature
AU - Gillis, Andrew J
AU - Schuller, Anthony P
AU - Skordalakes, Emmanuel
PY - 2008
DA - 2008/08/31 00:00:00
PB - Springer Nature
SP - 633-637
IS - 7213
VL - 455
SN - 0028-0836
SN - 1476-4687
ER -
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@article{2008_Gillis,
author = {Andrew J Gillis and Anthony P Schuller and Emmanuel Skordalakes},
title = {Structure of the Tribolium castaneum telomerase catalytic subunit TERT},
journal = {Nature},
year = {2008},
volume = {455},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038%2Fnature07283},
number = {7213},
pages = {633--637},
doi = {10.1038/nature07283}
}
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MLA
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Gillis, Andrew J., et al. “Structure of the Tribolium castaneum telomerase catalytic subunit TERT.” Nature, vol. 455, no. 7213, Aug. 2008, pp. 633-637. https://doi.org/10.1038%2Fnature07283.