Open Access

Nature, volume 551, issue 7681, pages 472-477

Visualization of chemical modifications in the human 80S ribosome structure

Natchiar S. Kundhavai ^{1, 2, 3, 4, 5}

Myasnikov Alexander G. ^{1, 2, 3, 4, 5}

Kratzat Hanna ^{1, 2, 3, 4, 5, 6}

Hazemann Isabelle ^{1, 2, 3, 4, 5}

Klaholz Bruno P. ^{1, 2, 3, 4, 5}

Hide authors affiliations Show authors affiliations: 6 affiliations

Institute of Genetics and of Molecular and Cellular Biology (IGBMC), Illkirch, France |

Université de Strasbourg, Illkirch, France |

Institut National de la Santé et de la Recherche Médicale (Inserm), Illkirch, France |

⁴

Centre National de la Recherche Scientifique (CNRS), Illkirch, France |

⁵

Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC, CNRS, Inserm, Université de Strasbourg, Illkirch, France |

⁶

Gene Center, Ludwig-Maximilians-Universität, Munich, Germany |

Publication type: Journal Article

Publication date: 2017-11-01

Springer Nature

Journal: Nature

Quartile SCImago

Quartile WOS

Impact factor: 64.8

ISSN: 00280836, 14764687

DOI: 10.1038/nature24482

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Multidisciplinary

Abstract

Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is found in cancer and other diseases. However, their role in this phenomenon is unknown. Here we visualize more than 130 individual rRNA modifications in the three-dimensional structure of the human ribosome, explaining their structural and functional roles. In addition to a small number of universally conserved sites, we identify many eukaryote- or human-specific modifications and unique sites that form an extended shell in comparison to bacterial ribosomes, and which stabilize the RNA. Several of the modifications are associated with the binding sites of three ribosome-targeting antibiotics, or are associated with degenerate states in cancer, such as keto alkylations on nucleotide bases reminiscent of specialized ribosomes. This high-resolution structure of the human 80S ribosome paves the way towards understanding the role of epigenetic rRNA modifications in human diseases and suggests new possibilities for designing selective inhibitors and therapeutic drugs.

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	5 10 15 20 25
Nucleic Acids Research	Nucleic Acids Research, 21, 7.72% Nucleic Acids Research 21 publications, 7.72%
Nature Communications	Nature Communications, 12, 4.41% Nature Communications 12 publications, 4.41%
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eLife	eLife, 7, 2.57% eLife 7 publications, 2.57%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 6, 2.21% International Journal of Molecular Sciences 6 publications, 2.21%
Cell Reports	Cell Reports, 6, 2.21% Cell Reports 6 publications, 2.21%
Biomolecules	Biomolecules, 5, 1.84% Biomolecules 5 publications, 1.84%
Molecular Cell	Molecular Cell, 5, 1.84% Molecular Cell 5 publications, 1.84%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 5, 1.84% Proceedings of the National Academy of Sciences of the United States of America 5 publications, 1.84%
Acta Crystallographica Section D: Structural Biology	Acta Crystallographica Section D: Structural Biology, 4, 1.47% Acta Crystallographica Section D: Structural Biology 4 publications, 1.47%
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Nature Structural and Molecular Biology	Nature Structural and Molecular Biology, 4, 1.47% Nature Structural and Molecular Biology 4 publications, 1.47%
Analytical Chemistry	Analytical Chemistry, 4, 1.47% Analytical Chemistry 4 publications, 1.47%
Science	Science, 4, 1.47% Science 4 publications, 1.47%
Nature Chemical Biology	Nature Chemical Biology, 3, 1.1% Nature Chemical Biology 3 publications, 1.1%
EMBO Journal	EMBO Journal, 3, 1.1% EMBO Journal 3 publications, 1.1%
Genes	Genes, 3, 1.1% Genes 3 publications, 1.1%
Cells	Cells, 3, 1.1% Cells 3 publications, 1.1%
Frontiers in Plant Science	Frontiers in Plant Science, 3, 1.1% Frontiers in Plant Science 3 publications, 1.1%
Frontiers in Genetics	Frontiers in Genetics, 3, 1.1% Frontiers in Genetics 3 publications, 1.1%
Nature	Nature, 3, 1.1% Nature 3 publications, 1.1%
Structure	Structure, 3, 1.1% Structure 3 publications, 1.1%
Journal of Structural Biology	Journal of Structural Biology, 3, 1.1% Journal of Structural Biology 3 publications, 1.1%
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RNA Biology	RNA Biology, 3, 1.1% RNA Biology 3 publications, 1.1%
NAR Cancer	NAR Cancer, 3, 1.1% NAR Cancer 3 publications, 1.1%
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Biomedicines	Biomedicines, 2, 0.74% Biomedicines 2 publications, 0.74%
	5 10 15 20 25

Citations by publishers

	5 10 15 20 25 30 35 40
Springer Nature	Springer Nature, 40, 14.71% Springer Nature 40 publications, 14.71%
Elsevier	Elsevier, 35, 12.87% Elsevier 35 publications, 12.87%
Oxford University Press	Oxford University Press, 25, 9.19% Oxford University Press 25 publications, 9.19%
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Wiley	Wiley, 19, 6.99% Wiley 19 publications, 6.99%
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Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 9, 3.31% Cold Spring Harbor Laboratory 9 publications, 3.31%
American Chemical Society (ACS)	American Chemical Society (ACS), 8, 2.94% American Chemical Society (ACS) 8 publications, 2.94%
eLife Sciences Publications	eLife Sciences Publications, 7, 2.57% eLife Sciences Publications 7 publications, 2.57%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 6, 2.21% American Association for the Advancement of Science (AAAS) 6 publications, 2.21%
Taylor & Francis	Taylor & Francis, 5, 1.84% Taylor & Francis 5 publications, 1.84%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 5, 1.84% Proceedings of the National Academy of Sciences (PNAS) 5 publications, 1.84%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 4, 1.47% International Union of Crystallography (IUCr) 4 publications, 1.47%
EMBO press	EMBO press, 3, 1.1% EMBO press 3 publications, 1.1%
Portland Press	Portland Press, 2, 0.74% Portland Press 2 publications, 0.74%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 0.74% American Society for Biochemistry and Molecular Biology 2 publications, 0.74%
Pleiades Publishing	Pleiades Publishing, 1, 0.37% Pleiades Publishing 1 publication, 0.37%
Acta Naturae Ltd	Acta Naturae Ltd, 1, 0.37% Acta Naturae Ltd 1 publication, 0.37%
Bentham Science	Bentham Science, 1, 0.37% Bentham Science 1 publication, 0.37%
EDP Sciences	EDP Sciences, 1, 0.37% EDP Sciences 1 publication, 0.37%
S. Karger AG	S. Karger AG, 1, 0.37% S. Karger AG 1 publication, 0.37%
Spandidos Publications	Spandidos Publications, 1, 0.37% Spandidos Publications 1 publication, 0.37%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.37% Public Library of Science (PLoS) 1 publication, 0.37%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 0.37% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 0.37%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 0.37% Royal Society of Chemistry (RSC) 1 publication, 0.37%
Walter de Gruyter	Walter de Gruyter, 1, 0.37% Walter de Gruyter 1 publication, 0.37%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 0.37% American Association for Cancer Research (AACR) 1 publication, 0.37%
American Physiological Society	American Physiological Society, 1, 0.37% American Physiological Society 1 publication, 0.37%
Rockefeller University Press	Rockefeller University Press, 1, 0.37% Rockefeller University Press 1 publication, 0.37%
	5 10 15 20 25 30 35 40

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GOST Copy

Natchiar S. K. et al. Visualization of chemical modifications in the human 80S ribosome structure // Nature. 2017. Vol. 551. No. 7681. pp. 472-477.

GOST all authors (up to 50) Copy

Natchiar S. K., Myasnikov A. G., Kratzat H., Hazemann I., Klaholz B. P. Visualization of chemical modifications in the human 80S ribosome structure // Nature. 2017. Vol. 551. No. 7681. pp. 472-477.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nature24482

UR - https://doi.org/10.1038%2Fnature24482

TI - Visualization of chemical modifications in the human 80S ribosome structure

T2 - Nature

AU - Natchiar, S. Kundhavai

AU - Myasnikov, Alexander G.

AU - Kratzat, Hanna

AU - Hazemann, Isabelle

AU - Klaholz, Bruno P.

PY - 2017

DA - 2017/11/01 00:00:00

PB - Springer Nature

SP - 472-477

IS - 7681

VL - 551

SN - 0028-0836

SN - 1476-4687

ER -

BibTex |

Cite this

BibTex Copy

@article{2017_Natchiar,

author = {S. Kundhavai Natchiar and Alexander G. Myasnikov and Hanna Kratzat and Isabelle Hazemann and Bruno P. Klaholz},

title = {Visualization of chemical modifications in the human 80S ribosome structure},

journal = {Nature},

year = {2017},

volume = {551},

publisher = {Springer Nature},

month = {nov},

url = {https://doi.org/10.1038%2Fnature24482},

number = {7681},

pages = {472--477},

doi = {10.1038/nature24482}

}

MLA

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MLA Copy

Natchiar, S. Kundhavai, et al. “Visualization of chemical modifications in the human 80S ribosome structure.” Nature, vol. 551, no. 7681, Nov. 2017, pp. 472-477. https://doi.org/10.1038%2Fnature24482.

Found error?

Publisher

Springer Nature

Journal

Nature

Quartile SCImago

Quartile WOS

Impact factor

64.8

ISSN

00280836 (Print)
14764687 (Electronic)