Nature Chemical Biology, volume 11, issue 1, pages 9-15
Targeting mitochondria metabolism for cancer therapy
1
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA
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Publication type: Journal Article
Publication date: 2014-12-17
Journal:
Nature Chemical Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.8
ISSN: 15524450, 15524469
PubMed ID:
25517383
Molecular Biology
Cell Biology
Abstract
Understanding how tumor cells utilize metabolic pathways for proliferation may provide useful strategies for combating cancer. A Perspective discusses recent advances in cancer drug development that target specific aspects of mitochondrial biosynthesis and bioenergetics processes. Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.
Citations by journals
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Weinberg S. E., Chandel N. S. Targeting mitochondria metabolism for cancer therapy // Nature Chemical Biology. 2014. Vol. 11. No. 1. pp. 9-15.
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Weinberg S. E., Chandel N. S. Targeting mitochondria metabolism for cancer therapy // Nature Chemical Biology. 2014. Vol. 11. No. 1. pp. 9-15.
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TY - JOUR
DO - 10.1038/nchembio.1712
UR - https://doi.org/10.1038%2Fnchembio.1712
TI - Targeting mitochondria metabolism for cancer therapy
T2 - Nature Chemical Biology
AU - Weinberg, Samuel E
AU - Chandel, Navdeep S.
PY - 2014
DA - 2014/12/17 00:00:00
PB - Springer Nature
SP - 9-15
IS - 1
VL - 11
PMID - 25517383
SN - 1552-4450
SN - 1552-4469
ER -
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@article{2014_Weinberg,
author = {Samuel E Weinberg and Navdeep S. Chandel},
title = {Targeting mitochondria metabolism for cancer therapy},
journal = {Nature Chemical Biology},
year = {2014},
volume = {11},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038%2Fnchembio.1712},
number = {1},
pages = {9--15},
doi = {10.1038/nchembio.1712}
}
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MLA
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Weinberg, Samuel E., and Navdeep S. Chandel. “Targeting mitochondria metabolism for cancer therapy.” Nature Chemical Biology, vol. 11, no. 1, Dec. 2014, pp. 9-15. https://doi.org/10.1038%2Fnchembio.1712.