Open Access
Nature Communications, volume 6, issue 1, publication number 6104
Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA
1
Stowers Institute for Medical Research, Kansas City, USA
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2
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA
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3
Present address: Memorial Sloan Kettering Cancer Center, 417 E 68th Street, New York, New York 10065, USA,
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4
Howard Hughes Medical Institute, Kansas City, USA
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Publication type: Journal Article
Publication date: 2015-01-19
Journal:
Nature Communications
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 20411723
PubMed ID:
25598145
General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy
Abstract
The 3′ end of Schizosaccharomyces pombe telomerase RNA (SpTER1) is generated by spliceosomal cleavage, a reaction that corresponds to the first step of splicing. The observation that the spliceosome functions in 3′ end processing raised questions about the evolutionary origin and conservation of this mechanism. We now present data in support of spliceosomes generating 3′ ends of telomerase RNAs in other fungi. Strikingly, the mechanistic basis for restricting spliceosomal splicing to the first transesterification reaction differs substantially among species. Unlike S. pombe, two other fission yeasts rely on hyperstabilization of the U6 snRNA—5′ splice site interaction to impede the 2nd step of splicing. In contrast, a non-canonical 5′ splice site blocks the second transesterification reaction in Aspergillus species. These results demonstrate a conserved role for spliceosomes functioning in 3′ end processing. Divergent mechanisms of uncoupling the two steps of splicing argue for multiple origins of this pathway.
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- We do not take into account publications that without a DOI.
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Kannan R. et al. Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA // Nature Communications. 2015. Vol. 6. No. 1. 6104
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Kannan R., Helston R. M., Dannebaum R. O., Baumann P. Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA // Nature Communications. 2015. Vol. 6. No. 1. 6104
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TY - JOUR
DO - 10.1038/ncomms7104
UR - https://doi.org/10.1038%2Fncomms7104
TI - Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA
T2 - Nature Communications
AU - Kannan, Ram
AU - Helston, Rachel M
AU - Dannebaum, Richard O
AU - Baumann, Peter
PY - 2015
DA - 2015/01/19 00:00:00
PB - Springer Nature
IS - 1
VL - 6
PMID - 25598145
SN - 2041-1723
ER -
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@article{2015_Kannan,
author = {Ram Kannan and Rachel M Helston and Richard O Dannebaum and Peter Baumann},
title = {Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA},
journal = {Nature Communications},
year = {2015},
volume = {6},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1038%2Fncomms7104},
number = {1},
doi = {10.1038/ncomms7104}
}