Open Access

Nature Genetics, volume 47, issue 12, pages 1482-1488

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

Moon Diane H. ^{1, 2, 3, 4}

Segal Matthew ^{1, 2, 3, 4}

Boyraz Baris ^{1, 2, 3, 4, 5}

Guinan Eva ⁶

Hofmann Inga ^{1, 2, 4}

Cahan Patrick ⁴

Tai Albert ⁷

Agarwal Suneet ^{1, 2, 3, 4}

Hide authors affiliations Show authors affiliations: 7 affiliations

Department of Pediatrics, Harvard Medical School, Boston, USA |

Harvard Stem Cell Institute, Boston, USA |

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, USA |

⁴

Division of Hematology/Oncology, Boston Children's Hospital, Boston, USA |

⁵

Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey |

⁶

Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, USA |

⁷

Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, USA |

Publication type: Journal Article

Publication date: 2015-10-19

Springer Nature

Journal: Nature Genetics

Quartile SCImago

Quartile WOS

Impact factor: 30.8

ISSN: 10614036, 15461718

DOI: 10.1038/ng.3423

Copy DOI

PubMed ID: 26482878

Genetics

Abstract

Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita, but how PARN deficiency impairs telomere maintenance is unclear. Here, using somatic cells and induced pluripotent stem cells (iPSCs) from patients with dyskeratosis congenita with PARN mutations, we show that PARN is required for the 3′-end maturation of the telomerase RNA component (TERC). Patient-derived cells as well as immortalized cells in which PARN is disrupted show decreased levels of TERC. Deep sequencing of TERC RNA 3′ termini shows that PARN is required for removal of post-transcriptionally acquired oligo(A) tails that target nuclear RNAs for degradation. Diminished TERC levels and the increased proportion of oligo(A) forms of TERC are normalized by restoring PARN, which is limiting for TERC maturation in cells. Our results demonstrate a new role for PARN in the biogenesis of TERC and provide a mechanism linking PARN mutations to telomere diseases.

By date By citations

Citations by journals

	1 2 3 4 5 6
Nature Communications	Nature Communications, 6, 4.41% Nature Communications 6 publications, 4.41%
Molecular Cell	Molecular Cell, 5, 3.68% Molecular Cell 5 publications, 3.68%
Cell Reports	Cell Reports, 5, 3.68% Cell Reports 5 publications, 3.68%
Nucleic Acids Research	Nucleic Acids Research, 5, 3.68% Nucleic Acids Research 5 publications, 3.68%
American Journal of Respiratory and Critical Care Medicine	American Journal of Respiratory and Critical Care Medicine, 4, 2.94% American Journal of Respiratory and Critical Care Medicine 4 publications, 2.94%
RNA Biology	RNA Biology, 4, 2.94% RNA Biology 4 publications, 2.94%
Scientific Reports	Scientific Reports, 3, 2.21% Scientific Reports 3 publications, 2.21%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 2.21% International Journal of Molecular Sciences 3 publications, 2.21%
Cells	Cells, 3, 2.21% Cells 3 publications, 2.21%
Blood advances	Blood advances, 3, 2.21% Blood advances 3 publications, 2.21%
Journal of Biological Chemistry	Journal of Biological Chemistry, 3, 2.21% Journal of Biological Chemistry 3 publications, 2.21%
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Journal of Clinical Investigation	Journal of Clinical Investigation, 2, 1.47% Journal of Clinical Investigation 2 publications, 1.47%
European Respiratory Journal	European Respiratory Journal, 2, 1.47% European Respiratory Journal 2 publications, 1.47%
Cancers	Cancers, 2, 1.47% Cancers 2 publications, 1.47%
Frontiers in Genetics	Frontiers in Genetics, 2, 1.47% Frontiers in Genetics 2 publications, 1.47%
Nature Structural and Molecular Biology	Nature Structural and Molecular Biology, 2, 1.47% Nature Structural and Molecular Biology 2 publications, 1.47%
Trends in Molecular Medicine	Trends in Molecular Medicine, 2, 1.47% Trends in Molecular Medicine 2 publications, 1.47%
Cell Stem Cell	Cell Stem Cell, 2, 1.47% Cell Stem Cell 2 publications, 1.47%
Advances in Biological Regulation	Advances in Biological Regulation, 2, 1.47% Advances in Biological Regulation 2 publications, 1.47%
Human Mutation	Human Mutation, 2, 1.47% Human Mutation 2 publications, 1.47%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 2, 1.47% Proceedings of the National Academy of Sciences of the United States of America 2 publications, 1.47%
Genes and Development	Genes and Development, 2, 1.47% Genes and Development 2 publications, 1.47%
Biomedicines	Biomedicines, 1, 0.74% Biomedicines 1 publication, 0.74%
Annals of Internal Medicine	Annals of Internal Medicine, 1, 0.74% Annals of Internal Medicine 1 publication, 0.74%
Annals of the American Thoracic Society	Annals of the American Thoracic Society, 1, 0.74% Annals of the American Thoracic Society 1 publication, 0.74%
European Respiratory Review	European Respiratory Review, 1, 0.74% European Respiratory Review 1 publication, 0.74%
F1000Research	F1000Research, 1, 0.74% F1000Research 1 publication, 0.74%
Philosophical Transactions of the Royal Society B: Biological Sciences	Philosophical Transactions of the Royal Society B: Biological Sciences, 1, 0.74% Philosophical Transactions of the Royal Society B: Biological Sciences 1 publication, 0.74%
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Citations by publishers

	5 10 15 20 25
Springer Nature	Springer Nature, 21, 15.44% Springer Nature 21 publications, 15.44%
Elsevier	Elsevier, 21, 15.44% Elsevier 21 publications, 15.44%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 14, 10.29% Multidisciplinary Digital Publishing Institute (MDPI) 14 publications, 10.29%
Wiley	Wiley, 9, 6.62% Wiley 9 publications, 6.62%
Taylor & Francis	Taylor & Francis, 9, 6.62% Taylor & Francis 9 publications, 6.62%
Oxford University Press	Oxford University Press, 8, 5.88% Oxford University Press 8 publications, 5.88%
American Thoracic Society	American Thoracic Society, 5, 3.68% American Thoracic Society 5 publications, 3.68%
Frontiers Media S.A.	Frontiers Media S.A., 4, 2.94% Frontiers Media S.A. 4 publications, 2.94%
American Society of Hematology	American Society of Hematology, 4, 2.94% American Society of Hematology 4 publications, 2.94%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 4, 2.94% Cold Spring Harbor Laboratory 4 publications, 2.94%
European Respiratory Society (ERS)	European Respiratory Society (ERS), 3, 2.21% European Respiratory Society (ERS) 3 publications, 2.21%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 3, 2.21% American Society for Biochemistry and Molecular Biology 3 publications, 2.21%
American Society for Clinical Investigation	American Society for Clinical Investigation, 2, 1.47% American Society for Clinical Investigation 2 publications, 1.47%
BMJ	BMJ, 2, 1.47% BMJ 2 publications, 1.47%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 2, 1.47% Proceedings of the National Academy of Sciences (PNAS) 2 publications, 1.47%
EMBO press	EMBO press, 2, 1.47% EMBO press 2 publications, 1.47%
American College of Physicians	American College of Physicians, 1, 0.74% American College of Physicians 1 publication, 0.74%
F1000 Research	F1000 Research, 1, 0.74% F1000 Research 1 publication, 0.74%
The Royal Society	The Royal Society, 1, 0.74% The Royal Society 1 publication, 0.74%
Histochemical Society	Histochemical Society, 1, 0.74% Histochemical Society 1 publication, 0.74%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.74% Public Library of Science (PLoS) 1 publication, 0.74%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.74% American Association for the Advancement of Science (AAAS) 1 publication, 0.74%
American Physiological Society	American Physiological Society, 1, 0.74% American Physiological Society 1 publication, 0.74%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.74% eLife Sciences Publications 1 publication, 0.74%
Portland Press	Portland Press, 1, 0.74% Portland Press 1 publication, 0.74%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 0.74% American Association for Cancer Research (AACR) 1 publication, 0.74%
	5 10 15 20 25

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Moon D. H. et al. Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component // Nature Genetics. 2015. Vol. 47. No. 12. pp. 1482-1488.

GOST all authors (up to 50) Copy

Moon D. H., Segal M., Boyraz B., Guinan E., Hofmann I., Cahan P., Tai A., Agarwal S. Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component // Nature Genetics. 2015. Vol. 47. No. 12. pp. 1482-1488.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/ng.3423

UR - https://doi.org/10.1038%2Fng.3423

TI - Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

T2 - Nature Genetics

AU - Moon, Diane H.

AU - Segal, Matthew

AU - Boyraz, Baris

AU - Guinan, Eva

AU - Hofmann, Inga

AU - Cahan, Patrick

AU - Tai, Albert

AU - Agarwal, Suneet

PY - 2015

DA - 2015/10/19 00:00:00

PB - Springer Nature

SP - 1482-1488

IS - 12

VL - 47

PMID - 26482878

SN - 1061-4036

SN - 1546-1718

ER -

BibTex |

Cite this

BibTex Copy

@article{2015_Moon,

author = {Diane H. Moon and Matthew Segal and Baris Boyraz and Eva Guinan and Inga Hofmann and Patrick Cahan and Albert Tai and Suneet Agarwal},

title = {Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component},

journal = {Nature Genetics},

year = {2015},

volume = {47},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1038%2Fng.3423},

number = {12},

pages = {1482--1488},

doi = {10.1038/ng.3423}

}

MLA

Cite this

MLA Copy

Moon, Diane H., et al. “Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component.” Nature Genetics, vol. 47, no. 12, Oct. 2015, pp. 1482-1488. https://doi.org/10.1038%2Fng.3423.

Found error?

Publisher

Springer Nature

Journal

Nature Genetics

Quartile SCImago

Quartile WOS

Impact factor

30.8

ISSN

10614036 (Print)
15461718 (Electronic)