Nature Reviews Clinical Oncology, volume 7, issue 12, pages 702-707
BRCA mutations in the management of breast cancer: the state of the art
1
Womens College Research Institute, Toronto, Canada
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Publication type: Journal Article
Publication date: 2010-10-19
Journal:
Nature Reviews Clinical Oncology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 78.8
ISSN: 17594774, 17594782
Oncology
Abstract
Genetic testing for BRCA1 and BRCA2 mutations is gaining acceptance in clinical oncology worldwide and may help target unaffected high-risk women for prevention and for close surveillance. Annual screening with MRI seems to be an effective surveillance strategy, but the long term follow-up of women with small MRI-detected breast cancers is necessary to establish its ultimate value. Women with cancer and a BRCA mutation may benefit from tailored treatments, such as cisplatin or olaparib. The treatment goals for a woman with a BRCA-associated breast cancer should be to prevent recurrence of the initial cancer and to prevent second primary breast and ovarian cancers. Mutations in BRCA1 and BRCA2 are presented throughout the world and it is important that the benefits of genetic testing and of targeted therapies be extended to women who live outside of North America and Western Europe.
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Citations by publishers
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5
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35
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Narod S. A. BRCA mutations in the management of breast cancer: the state of the art // Nature Reviews Clinical Oncology. 2010. Vol. 7. No. 12. pp. 702-707.
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Narod S. A. BRCA mutations in the management of breast cancer: the state of the art // Nature Reviews Clinical Oncology. 2010. Vol. 7. No. 12. pp. 702-707.
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TY - JOUR
DO - 10.1038/nrclinonc.2010.166
UR - https://doi.org/10.1038%2Fnrclinonc.2010.166
TI - BRCA mutations in the management of breast cancer: the state of the art
T2 - Nature Reviews Clinical Oncology
AU - Narod, Steven A.
PY - 2010
DA - 2010/10/19 00:00:00
PB - Springer Nature
SP - 702-707
IS - 12
VL - 7
SN - 1759-4774
SN - 1759-4782
ER -
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@article{2010_Narod,
author = {Steven A. Narod},
title = {BRCA mutations in the management of breast cancer: the state of the art},
journal = {Nature Reviews Clinical Oncology},
year = {2010},
volume = {7},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1038%2Fnrclinonc.2010.166},
number = {12},
pages = {702--707},
doi = {10.1038/nrclinonc.2010.166}
}
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MLA
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Narod, Steven A.. “BRCA mutations in the management of breast cancer: the state of the art.” Nature Reviews Clinical Oncology, vol. 7, no. 12, Oct. 2010, pp. 702-707. https://doi.org/10.1038%2Fnrclinonc.2010.166.