Nature Reviews Molecular Cell Biology, volume 17, issue 4, pages 227-239
The regulation and functions of the nuclear RNA exosome complex
Publication type: Journal Article
Publication date: 2016-01-04
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
Molecular Biology
Cell Biology
Abstract
The versatile RNA-degradation functions of the RNA exosome complex make it crucial for RNA biogenesis. It is now emerging that the nuclear exosome is a specific regulator of gene expression in different physiological processes, and that it has a role in transcription regulation and in maintaining genome stability. The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes. The exosome has a central role in several aspects of RNA biogenesis, including RNA maturation and surveillance. Moreover, it is emerging as an important player in regulating the expression levels of specific mRNAs in response to environmental cues and during cell differentiation and development. Although the mechanisms by which RNA is targeted to (or escapes from) the exosome are still not fully understood, general principles have begun to emerge, which we discuss in this Review. In addition, we introduce and discuss novel, previously unappreciated functions of the nuclear exosome, including in transcription regulation and in the maintenance of genome stability.
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- We do not take into account publications that without a DOI.
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Kilchert C., Wittmann S., Vasiljeva L. The regulation and functions of the nuclear RNA exosome complex // Nature Reviews Molecular Cell Biology. 2016. Vol. 17. No. 4. pp. 227-239.
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Kilchert C., Wittmann S., Vasiljeva L. The regulation and functions of the nuclear RNA exosome complex // Nature Reviews Molecular Cell Biology. 2016. Vol. 17. No. 4. pp. 227-239.
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TY - JOUR
DO - 10.1038/nrm.2015.15
UR - https://doi.org/10.1038%2Fnrm.2015.15
TI - The regulation and functions of the nuclear RNA exosome complex
T2 - Nature Reviews Molecular Cell Biology
AU - Kilchert, Cornelia
AU - Wittmann, Sina
AU - Vasiljeva, Lidia
PY - 2016
DA - 2016/01/04 00:00:00
PB - Springer Nature
SP - 227-239
IS - 4
VL - 17
SN - 1471-0072
SN - 1471-0080
ER -
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@article{2016_Kilchert,
author = {Cornelia Kilchert and Sina Wittmann and Lidia Vasiljeva},
title = {The regulation and functions of the nuclear RNA exosome complex},
journal = {Nature Reviews Molecular Cell Biology},
year = {2016},
volume = {17},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1038%2Fnrm.2015.15},
number = {4},
pages = {227--239},
doi = {10.1038/nrm.2015.15}
}
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Kilchert, Cornelia, et al. “The regulation and functions of the nuclear RNA exosome complex.” Nature Reviews Molecular Cell Biology, vol. 17, no. 4, Jan. 2016, pp. 227-239. https://doi.org/10.1038%2Fnrm.2015.15.