Nature Reviews Molecular Cell Biology, volume 19, issue 4, pages 262-274
Transcription regulation by the Mediator complex
1
Institute for Integrative Biology of the Cell (I2BC), Institute of Life Sciences Frédéric Joliot, Commissariat à l'énergie Atomique et aux énergies alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), University Paris Sud, University Paris Saclay, France
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Publication type: Journal Article
Publication date: 2017-12-06
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
Molecular Biology
Cell Biology
Abstract
Alterations in the regulation of gene expression are frequently associated with developmental diseases or cancer. Transcription activation is a key phenomenon in the regulation of gene expression. In all eukaryotes, mediator of RNA polymerase II transcription (Mediator), a large complex with modular organization, is generally required for transcription by RNA polymerase II, and it regulates various steps of this process. The main function of Mediator is to transduce signals from the transcription activators bound to enhancer regions to the transcription machinery, which is assembled at promoters as the preinitiation complex (PIC) to control transcription initiation. Recent functional studies of Mediator with the use of structural biology approaches and functional genomics have revealed new insights into Mediator activity and its regulation during transcription initiation, including how Mediator is recruited to transcription regulatory regions and how it interacts and cooperates with PIC components to assist in PIC assembly. Novel roles of Mediator in the control of gene expression have also been revealed by showing its connection to the nuclear pore and linking Mediator to the regulation of gene positioning in the nuclear space. Clear links between Mediator subunits and disease have also encouraged studies to explore targeting of this complex as a potential therapeutic approach in cancer and fungal infections.
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- We do not take into account publications that without a DOI.
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Soutourina J. Transcription regulation by the Mediator complex // Nature Reviews Molecular Cell Biology. 2017. Vol. 19. No. 4. pp. 262-274.
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Soutourina J. Transcription regulation by the Mediator complex // Nature Reviews Molecular Cell Biology. 2017. Vol. 19. No. 4. pp. 262-274.
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TY - JOUR
DO - 10.1038/nrm.2017.115
UR - https://doi.org/10.1038%2Fnrm.2017.115
TI - Transcription regulation by the Mediator complex
T2 - Nature Reviews Molecular Cell Biology
AU - Soutourina, Julie
PY - 2017
DA - 2017/12/06 00:00:00
PB - Springer Nature
SP - 262-274
IS - 4
VL - 19
SN - 1471-0072
SN - 1471-0080
ER -
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@article{2017_Soutourina,
author = {Julie Soutourina},
title = {Transcription regulation by the Mediator complex},
journal = {Nature Reviews Molecular Cell Biology},
year = {2017},
volume = {19},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038%2Fnrm.2017.115},
number = {4},
pages = {262--274},
doi = {10.1038/nrm.2017.115}
}
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Soutourina, Julie. “Transcription regulation by the Mediator complex.” Nature Reviews Molecular Cell Biology, vol. 19, no. 4, Dec. 2017, pp. 262-274. https://doi.org/10.1038%2Fnrm.2017.115.