Open Access
Nature Reviews Molecular Cell Biology, volume 12, issue 12, pages 827-841
All tangled up: how cells direct, manage and exploit topoisomerase function
1
Department of Molecular and Cell Biology, 374D Stanley Hall #3220, University of California, Berkeley, Berkeley, USA
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Publication type: Journal Article
Publication date: 2011-11-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
DOI:
10.1038/nrm3228
PubMed ID:
22108601
Molecular Biology
Cell Biology
Abstract
Topoisomerases are complex molecular machines that modulate DNA topology to maintain chromosome superstructure and integrity. Although capable of stand-alone activity in vitro, topoisomerases are frequently linked to larger pathways and systems that resolve specific DNA superstructures and intermediates arising from cellular processes such as DNA repair, transcription, replication and chromosome compaction. Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various exogenous agents that interfere with cell proliferation. Despite decades of study, surprising findings involving topoisomerases continue to emerge with respect to their cellular function, regulation and utility as therapeutic targets.
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Vos S. M. et al. All tangled up: how cells direct, manage and exploit topoisomerase function // Nature Reviews Molecular Cell Biology. 2011. Vol. 12. No. 12. pp. 827-841.
GOST all authors (up to 50)
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Vos S. M., Tretter E. M., Schmidt B. H., Berger J. M. All tangled up: how cells direct, manage and exploit topoisomerase function // Nature Reviews Molecular Cell Biology. 2011. Vol. 12. No. 12. pp. 827-841.
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RIS
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TY - JOUR
DO - 10.1038/nrm3228
UR - https://doi.org/10.1038%2Fnrm3228
TI - All tangled up: how cells direct, manage and exploit topoisomerase function
T2 - Nature Reviews Molecular Cell Biology
AU - Vos, Seychelle M
AU - Tretter, Elsa M
AU - Schmidt, Bryan H
AU - Berger, James M.
PY - 2011
DA - 2011/11/23 00:00:00
PB - Springer Nature
SP - 827-841
IS - 12
VL - 12
PMID - 22108601
SN - 1471-0072
SN - 1471-0080
ER -
Cite this
BibTex
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@article{2011_Vos,
author = {Seychelle M Vos and Elsa M Tretter and Bryan H Schmidt and James M. Berger},
title = {All tangled up: how cells direct, manage and exploit topoisomerase function},
journal = {Nature Reviews Molecular Cell Biology},
year = {2011},
volume = {12},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1038%2Fnrm3228},
number = {12},
pages = {827--841},
doi = {10.1038/nrm3228}
}
Cite this
MLA
Copy
Vos, Seychelle M., et al. “All tangled up: how cells direct, manage and exploit topoisomerase function.” Nature Reviews Molecular Cell Biology, vol. 12, no. 12, Nov. 2011, pp. 827-841. https://doi.org/10.1038%2Fnrm3228.