Open Access
Nature Reviews Molecular Cell Biology, volume 14, issue 2, pages 69-82
Finding the end: recruitment of telomerase to telomeres
1
Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, BioFrontiers Institute, University of Colorado, Boulder, USA
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Publication type: Journal Article
Publication date: 2013-01-09
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
DOI:
10.1038/nrm3505
PubMed ID:
23299958
Molecular Biology
Cell Biology
Abstract
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit repair by telomere-associated proteins, which in mammals form the shelterin complex. Replicative polymerases are unable to synthesize DNA at the extreme ends of chromosomes, but in unicellular eukaryotes such as yeast and in mammalian germ cells and stem cells, telomere length is maintained by a ribonucleoprotein enzyme known as telomerase. Recent work has provided insights into the mechanisms of telomerase recruitment to telomeres, highlighting the contribution of telomere-associated proteins, including TPP1 in humans, Ccq1 in Schizosaccharomyces pombe and Cdc13 and Ku70–Ku80 in Saccharomyces cerevisiae.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nandakumar J., Cech T. R. Finding the end: recruitment of telomerase to telomeres // Nature Reviews Molecular Cell Biology. 2013. Vol. 14. No. 2. pp. 69-82.
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Nandakumar J., Cech T. R. Finding the end: recruitment of telomerase to telomeres // Nature Reviews Molecular Cell Biology. 2013. Vol. 14. No. 2. pp. 69-82.
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TY - JOUR
DO - 10.1038/nrm3505
UR - https://doi.org/10.1038%2Fnrm3505
TI - Finding the end: recruitment of telomerase to telomeres
T2 - Nature Reviews Molecular Cell Biology
AU - Nandakumar, Jayakrishnan
AU - Cech, Thomas R
PY - 2013
DA - 2013/01/09 00:00:00
PB - Springer Nature
SP - 69-82
IS - 2
VL - 14
PMID - 23299958
SN - 1471-0072
SN - 1471-0080
ER -
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@article{2013_Nandakumar,
author = {Jayakrishnan Nandakumar and Thomas R Cech},
title = {Finding the end: recruitment of telomerase to telomeres},
journal = {Nature Reviews Molecular Cell Biology},
year = {2013},
volume = {14},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1038%2Fnrm3505},
number = {2},
pages = {69--82},
doi = {10.1038/nrm3505}
}
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MLA
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Nandakumar, Jayakrishnan, and Thomas R Cech. “Finding the end: recruitment of telomerase to telomeres.” Nature Reviews Molecular Cell Biology, vol. 14, no. 2, Jan. 2013, pp. 69-82. https://doi.org/10.1038%2Fnrm3505.