Nature Reviews Microbiology, volume 8, issue 6, pages 423-435

How antibiotics kill bacteria: from targets to networks

Kohanski Michael A. ^{1, 2}

Dwyer Daniel J. ¹

Collins James J. ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Howard Hughes Medical Institute and the Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, Boston, USA |

Boston University School Of Medicine, Boston, USA |

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA |

Publication type: Journal Article

Publication date: 2010-05-04

Springer Nature

Journal: Nature Reviews Microbiology

Quartile SCImago

Quartile WOS

Impact factor: 88.1

ISSN: 17401526, 17401534

DOI: 10.1038/nrmicro2333

Copy DOI

PubMed ID: 20440275

Microbiology

Infectious Diseases

General Immunology and Microbiology

Abstract

Bacterial responses to antibiotics are complex and involve many genetic and biochemical pathways. This Review describes the effects of bactericidal antibiotics on bacterial cellular processes, the associated responses that contribute to killing and recent insights into these processes revealed through the study of biological networks. Antibiotic drug–target interactions, and their respective direct effects, are generally well characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to cell death are not as well understood and have proven to be complex as they involve many genetic and biochemical pathways. In this Review, we discuss the multilayered effects of drug–target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response mechanisms that contribute to killing. We also discuss new insights into these mechanisms that have been revealed through the study of biological networks, and describe how these insights, together with related developments in synthetic biology, could be exploited to create new antibacterial therapies.

By date By citations

Citations by journals

	5 10 15 20 25 30 35 40 45
Frontiers in Microbiology	Frontiers in Microbiology, 42, 2.85% Frontiers in Microbiology 42 publications, 2.85%
Antimicrobial Agents and Chemotherapy	Antimicrobial Agents and Chemotherapy, 36, 2.44% Antimicrobial Agents and Chemotherapy 36 publications, 2.44%
Antibiotics	Antibiotics, 27, 1.83% Antibiotics 27 publications, 1.83%
PLoS ONE	PLoS ONE, 24, 1.63% PLoS ONE 24 publications, 1.63%
Molecules	Molecules, 18, 1.22% Molecules 18 publications, 1.22%
Scientific Reports	Scientific Reports, 17, 1.15% Scientific Reports 17 publications, 1.15%
mBio	mBio, 16, 1.08% mBio 16 publications, 1.08%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 15, 1.02% International Journal of Molecular Sciences 15 publications, 1.02%
Nature Communications	Nature Communications, 15, 1.02% Nature Communications 15 publications, 1.02%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 14, 0.95% Proceedings of the National Academy of Sciences of the United States of America 14 publications, 0.95%
Journal of Antimicrobial Chemotherapy	Journal of Antimicrobial Chemotherapy, 13, 0.88% Journal of Antimicrobial Chemotherapy 13 publications, 0.88%
Journal of Hazardous Materials	Journal of Hazardous Materials, 12, 0.81% Journal of Hazardous Materials 12 publications, 0.81%
Microbial Pathogenesis	Microbial Pathogenesis, 11, 0.75% Microbial Pathogenesis 11 publications, 0.75%
ACS applied materials & interfaces	ACS applied materials & interfaces, 11, 0.75% ACS applied materials & interfaces 11 publications, 0.75%
Food Control	Food Control, 11, 0.75% Food Control 11 publications, 0.75%
Journal of Bacteriology	Journal of Bacteriology, 10, 0.68% Journal of Bacteriology 10 publications, 0.68%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 8, 0.54% Frontiers in Cellular and Infection Microbiology 8 publications, 0.54%
ACS Infectious Diseases	ACS Infectious Diseases, 8, 0.54% ACS Infectious Diseases 8 publications, 0.54%
Nanomaterials	Nanomaterials, 7, 0.47% Nanomaterials 7 publications, 0.47%
Nature Reviews Microbiology	Nature Reviews Microbiology, 7, 0.47% Nature Reviews Microbiology 7 publications, 0.47%
Science of the Total Environment	Science of the Total Environment, 7, 0.47% Science of the Total Environment 7 publications, 0.47%
Free Radical Biology and Medicine	Free Radical Biology and Medicine, 7, 0.47% Free Radical Biology and Medicine 7 publications, 0.47%
Chemosphere	Chemosphere, 7, 0.47% Chemosphere 7 publications, 0.47%
Biomaterials Science	Biomaterials Science, 7, 0.47% Biomaterials Science 7 publications, 0.47%
Pharmaceuticals	Pharmaceuticals, 6, 0.41% Pharmaceuticals 6 publications, 0.41%
Microorganisms	Microorganisms, 6, 0.41% Microorganisms 6 publications, 0.41%
Pharmaceutics	Pharmaceutics, 6, 0.41% Pharmaceutics 6 publications, 0.41%
Applied Microbiology and Biotechnology	Applied Microbiology and Biotechnology, 6, 0.41% Applied Microbiology and Biotechnology 6 publications, 0.41%
BMC Microbiology	BMC Microbiology, 6, 0.41% BMC Microbiology 6 publications, 0.41%
	5 10 15 20 25 30 35 40 45

Citations by publishers

	50 100 150 200 250 300 350
Elsevier	Elsevier, 322, 21.82% Elsevier 322 publications, 21.82%
Springer Nature	Springer Nature, 160, 10.84% Springer Nature 160 publications, 10.84%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 128, 8.67% Multidisciplinary Digital Publishing Institute (MDPI) 128 publications, 8.67%
Wiley	Wiley, 118, 7.99% Wiley 118 publications, 7.99%
American Society for Microbiology	American Society for Microbiology, 87, 5.89% American Society for Microbiology 87 publications, 5.89%
American Chemical Society (ACS)	American Chemical Society (ACS), 80, 5.42% American Chemical Society (ACS) 80 publications, 5.42%
Frontiers Media S.A.	Frontiers Media S.A., 61, 4.13% Frontiers Media S.A. 61 publications, 4.13%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 57, 3.86% Royal Society of Chemistry (RSC) 57 publications, 3.86%
Taylor & Francis	Taylor & Francis, 42, 2.85% Taylor & Francis 42 publications, 2.85%
Oxford University Press	Oxford University Press, 41, 2.78% Oxford University Press 41 publications, 2.78%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 35, 2.37% Public Library of Science (PLoS) 35 publications, 2.37%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 14, 0.95% Proceedings of the National Academy of Sciences (PNAS) 14 publications, 0.95%
Bentham Science	Bentham Science, 10, 0.68% Bentham Science 10 publications, 0.68%
Future Medicine	Future Medicine, 10, 0.68% Future Medicine 10 publications, 0.68%
The Royal Society	The Royal Society, 8, 0.54% The Royal Society 8 publications, 0.54%
Hindawi Limited	Hindawi Limited, 8, 0.54% Hindawi Limited 8 publications, 0.54%
Microbiology Society	Microbiology Society, 7, 0.47% Microbiology Society 7 publications, 0.47%
IOP Publishing	IOP Publishing, 7, 0.47% IOP Publishing 7 publications, 0.47%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 6, 0.41% American Association for the Advancement of Science (AAAS) 6 publications, 0.41%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 6, 0.41% American Society for Biochemistry and Molecular Biology 6 publications, 0.41%
Pleiades Publishing	Pleiades Publishing, 6, 0.41% Pleiades Publishing 6 publications, 0.41%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 5, 0.34% American Institute of Physics (AIP) 5 publications, 0.34%
SAGE	SAGE, 5, 0.34% SAGE 5 publications, 0.34%
Mary Ann Liebert	Mary Ann Liebert, 4, 0.27% Mary Ann Liebert 4 publications, 0.27%
PeerJ	PeerJ, 4, 0.27% PeerJ 4 publications, 0.27%
Cambridge University Press	Cambridge University Press, 4, 0.27% Cambridge University Press 4 publications, 0.27%
Biophysical Society	Biophysical Society, 4, 0.27% Biophysical Society 4 publications, 0.27%
Dove Medical Press	Dove Medical Press, 4, 0.27% Dove Medical Press 4 publications, 0.27%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 3, 0.2% International Union of Crystallography (IUCr) 3 publications, 0.2%
	50 100 150 200 250 300 350

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GOST Copy

Kohanski M. A. et al. How antibiotics kill bacteria: from targets to networks // Nature Reviews Microbiology. 2010. Vol. 8. No. 6. pp. 423-435.

GOST all authors (up to 50) Copy

Kohanski M. A., Dwyer D. J., Collins J. J. How antibiotics kill bacteria: from targets to networks // Nature Reviews Microbiology. 2010. Vol. 8. No. 6. pp. 423-435.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nrmicro2333

UR - https://doi.org/10.1038%2Fnrmicro2333

TI - How antibiotics kill bacteria: from targets to networks

T2 - Nature Reviews Microbiology

AU - Kohanski, Michael A.

AU - Dwyer, Daniel J.

AU - Collins, James J.

PY - 2010

DA - 2010/05/04 00:00:00

PB - Springer Nature

SP - 423-435

IS - 6

VL - 8

PMID - 20440275

SN - 1740-1526

SN - 1740-1534

ER -

BibTex |

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BibTex Copy

@article{2010_Kohanski,

author = {Michael A. Kohanski and Daniel J. Dwyer and James J. Collins},

title = {How antibiotics kill bacteria: from targets to networks},

journal = {Nature Reviews Microbiology},

year = {2010},

volume = {8},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1038%2Fnrmicro2333},

number = {6},

pages = {423--435},

doi = {10.1038/nrmicro2333}

}

MLA

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MLA Copy

Kohanski, Michael A., et al. “How antibiotics kill bacteria: from targets to networks.” Nature Reviews Microbiology, vol. 8, no. 6, May. 2010, pp. 423-435. https://doi.org/10.1038%2Fnrmicro2333.

Found error?

Publisher

Springer Nature

Journal

Nature Reviews Microbiology

Quartile SCImago

Quartile WOS

Impact factor

88.1

ISSN

17401526 (Print)
17401534 (Electronic)