Nature Reviews Microbiology, volume 12, issue 1, pages 35-48
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
1
Gene Center and Department for Biochemistry, Feodor-Lynenstr. 25, University of Munich, Munich, Germany
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Publication type: Journal Article
Publication date: 2013-12-16
Journal:
Nature Reviews Microbiology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 88.1
ISSN: 17401526, 17401534
Microbiology
Infectious Diseases
General Immunology and Microbiology
Abstract
The ribosome is one of the primary antibiotic targets in the bacterial cell. Here, Daniel Wilson discusses how high-resolution crystal structures of antibiotic–ribosome complexes have provided molecular insight into the mechanisms of antibiotic action and bacterial resistance, in addition to the approaches being pursued for the development of improved and novel ribosome-targeting antibiotics. The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Wilson D. N. Ribosome-targeting antibiotics and mechanisms of bacterial resistance // Nature Reviews Microbiology. 2013. Vol. 12. No. 1. pp. 35-48.
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Wilson D. N. Ribosome-targeting antibiotics and mechanisms of bacterial resistance // Nature Reviews Microbiology. 2013. Vol. 12. No. 1. pp. 35-48.
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TY - JOUR
DO - 10.1038/nrmicro3155
UR - https://doi.org/10.1038%2Fnrmicro3155
TI - Ribosome-targeting antibiotics and mechanisms of bacterial resistance
T2 - Nature Reviews Microbiology
AU - Wilson, Daniel N.
PY - 2013
DA - 2013/12/16 00:00:00
PB - Springer Nature
SP - 35-48
IS - 1
VL - 12
SN - 1740-1526
SN - 1740-1534
ER -
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@article{2013_Wilson,
author = {Daniel N. Wilson},
title = {Ribosome-targeting antibiotics and mechanisms of bacterial resistance},
journal = {Nature Reviews Microbiology},
year = {2013},
volume = {12},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038%2Fnrmicro3155},
number = {1},
pages = {35--48},
doi = {10.1038/nrmicro3155}
}
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MLA
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Wilson, Daniel N.. “Ribosome-targeting antibiotics and mechanisms of bacterial resistance.” Nature Reviews Microbiology, vol. 12, no. 1, Dec. 2013, pp. 35-48. https://doi.org/10.1038%2Fnrmicro3155.