Open Access
Nature Structural and Molecular Biology, volume 20, issue 12, pages 1367-1376
The human cap-binding complex is functionally connected to the nuclear RNA exosome
Andersen Peter Refsing
1
,
Domanski Michal
1, 2
,
Kristiansen Maiken S
1, 3
,
Storvall Helena
4
,
Ntini Evgenia
1
,
Verheggen Céline
5
,
Schein Aleks
1, 3
,
Bunkenborg Jakob
6
,
Poser Ina
7
,
Hallais Marie
5
,
Sandberg Rickard
4
,
Hyman Anthony
7
,
LaCava John
2
,
Rout Michael P.
2
,
ANDERSEN Jens S.
6
,
Bertrand Edouard
5
,
Jensen Torben Heick
1
2
Laboratory of Cellular and Structural Biology, Rockefeller University, New York, USA
|
3
Present addresses: Sir William Dunn School of Pathology, University of Oxford, Oxford, UK (M.S.K.), and Division of Genomic Technologies, RIKEN, Yokohama City, Japan (A.S.).,
|
5
Institute de Génétique Moléculaire Montpellier, CNRS, Montpellier, France
|
6
7
Max Planck Institute of Molecular Biology & Genetics, Dresden, Germany
|
Publication type: Journal Article
Publication date: 2013-11-24
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.8
ISSN: 15459993, 15459985
PubMed ID:
24270879
Molecular Biology
Structural Biology
Abstract
Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome, which is regulated by accessory factors. However, the mechanism of exosome recruitment to its ribonucleoprotein (RNP) targets remains poorly understood. Here we report a physical link between the human exosome and the cap-binding complex (CBC). The CBC associates with the ARS2 protein to form CBC–ARS2 (CBCA) and then further connects, together with the ZC3H18 protein, to the nuclear exosome targeting (NEXT) complex, thus forming CBC–NEXT (CBCN). RNA immunoprecipitation using CBCN factors as well as the analysis of combinatorial depletion of CBCN and exosome components underscore the functional relevance of CBC-exosome bridging at the level of target RNA. Specifically, CBCA suppresses read-through products of several RNA families by promoting their transcriptional termination. We suggest that the RNP 5′ cap links transcription termination to exosomal RNA degradation through CBCN.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Andersen P. R. et al. The human cap-binding complex is functionally connected to the nuclear RNA exosome // Nature Structural and Molecular Biology. 2013. Vol. 20. No. 12. pp. 1367-1376.
GOST all authors (up to 50)
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Andersen P. R., Domanski M., Kristiansen M. S., Storvall H., Ntini E., Verheggen C., Schein A., Bunkenborg J., Poser I., Hallais M., Sandberg R., Hyman A., LaCava J., Rout M. P., ANDERSEN J. S., Bertrand E., Jensen T. H. The human cap-binding complex is functionally connected to the nuclear RNA exosome // Nature Structural and Molecular Biology. 2013. Vol. 20. No. 12. pp. 1367-1376.
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RIS
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TY - JOUR
DO - 10.1038/nsmb.2703
UR - https://doi.org/10.1038%2Fnsmb.2703
TI - The human cap-binding complex is functionally connected to the nuclear RNA exosome
T2 - Nature Structural and Molecular Biology
AU - Andersen, Peter Refsing
AU - Domanski, Michal
AU - Kristiansen, Maiken S
AU - Storvall, Helena
AU - Ntini, Evgenia
AU - Verheggen, Céline
AU - Schein, Aleks
AU - Bunkenborg, Jakob
AU - Poser, Ina
AU - Hallais, Marie
AU - Sandberg, Rickard
AU - Hyman, Anthony
AU - LaCava, John
AU - Rout, Michael P.
AU - ANDERSEN, Jens S.
AU - Bertrand, Edouard
AU - Jensen, Torben Heick
PY - 2013
DA - 2013/11/24 00:00:00
PB - Springer Nature
SP - 1367-1376
IS - 12
VL - 20
PMID - 24270879
SN - 1545-9993
SN - 1545-9985
ER -
Cite this
BibTex
Copy
@article{2013_Andersen,
author = {Peter Refsing Andersen and Michal Domanski and Maiken S Kristiansen and Helena Storvall and Evgenia Ntini and Céline Verheggen and Aleks Schein and Jakob Bunkenborg and Ina Poser and Marie Hallais and Rickard Sandberg and Anthony Hyman and John LaCava and Michael P. Rout and Jens S. ANDERSEN and Edouard Bertrand and Torben Heick Jensen},
title = {The human cap-binding complex is functionally connected to the nuclear RNA exosome},
journal = {Nature Structural and Molecular Biology},
year = {2013},
volume = {20},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1038%2Fnsmb.2703},
number = {12},
pages = {1367--1376},
doi = {10.1038/nsmb.2703}
}
Cite this
MLA
Copy
Andersen, Peter Refsing, et al. “The human cap-binding complex is functionally connected to the nuclear RNA exosome.” Nature Structural and Molecular Biology, vol. 20, no. 12, Nov. 2013, pp. 1367-1376. https://doi.org/10.1038%2Fnsmb.2703.