Nature Structural and Molecular Biology, volume 20, issue 12, pages 1358-1366

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

Hallais Marie ¹

Pontvianne Frédéric ^{1, 2}

Andersen Peter Refsing ³

Clerici Marcello ⁴

Lener Daniela ^{1, 2}

Benbahouche Nour El Houda ¹

Gostan Thierry ¹

Vandermoere Franck ⁵

Robert Marie Cécile ¹

Cusack Stephen ⁴

Verheggen Céline ¹

Jensen Torben Heick ³

Bertrand Edouard ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Equipe labellisée Ligue contre le Cancer, Institut de Génétique Moléculaire de Montpellier–Centre National de la Recherche Scientifique, Montpellier, France |

Present addresses: Laboratoire Génome et Développement des Plantes, Centre National de la Recherche Scientifique, Perpignan, France (F.P.) and Institut de Génétique et de Biologie Moléculaire et Cellulaire–Centre National de la Recherche Scientifique, Strasbourg, France (D.L.)., |

Department of Molecular Biology and Genetics, Centre for mRNP Biogenesis and Metabolism, Aarhus University, Aarhus, Denmark |

⁴

European Molecular Biology Laboratory Grenoble Outstation, Grenoble, France |

⁵

Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Montpellier, France |

Publication type: Journal Article

Publication date: 2013-11-24

Springer Nature

Journal: Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor: 16.8

ISSN: 15459993, 15459985

DOI: 10.1038/nsmb.2720

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Molecular Biology

Structural Biology

Abstract

The nuclear cap–binding complex (CBC) stimulates RNA maturation, but the mechanistic basis is not well understood. In vitro reconstitution experiments combined with functional analyses have revealed a new CBC complex containing ARS2, a major effector of CBC. ARS2 links the cap to 3'-end maturation for several RNA families, thus favoring the production of short RNAs. The nuclear cap–binding complex (CBC) stimulates multiple steps in several RNA maturation pathways, but how it functions in humans is incompletely understood. For small, capped RNAs such as pre-snRNAs, the CBC recruits PHAX. Here, we identify the CBCAP complex, composed of CBC, ARS2 and PHAX, and show that both CBCAP and CBC–ARS2 complexes can be reconstituted from recombinant proteins. ARS2 stimulates PHAX binding to the CBC and snRNA 3′-end processing, thereby coupling maturation with export. In vivo, CBC and ARS2 bind similar capped noncoding and coding RNAs and stimulate their 3′-end processing. The strongest effects are for cap-proximal polyadenylation sites, and this favors premature transcription termination. ARS2 functions partly through the mRNA 3′-end cleavage factor CLP1, which binds RNA Polymerase II through PCF11. ARS2 is thus a major CBC effector that stimulates functional and cryptic 3′-end processing sites.

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Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 0.72% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 0.72%
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Hallais M. et al. CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing // Nature Structural and Molecular Biology. 2013. Vol. 20. No. 12. pp. 1358-1366.

GOST all authors (up to 50) Copy

Hallais M., Pontvianne F., Andersen P. R., Clerici M., Lener D., Benbahouche N. E. H., Gostan T., Vandermoere F., Robert M. C., Cusack S., Verheggen C., Jensen T. H., Bertrand E. CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing // Nature Structural and Molecular Biology. 2013. Vol. 20. No. 12. pp. 1358-1366.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nsmb.2720

UR - https://doi.org/10.1038%2Fnsmb.2720

TI - CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

T2 - Nature Structural and Molecular Biology

AU - Hallais, Marie

AU - Pontvianne, Frédéric

AU - Andersen, Peter Refsing

AU - Clerici, Marcello

AU - Lener, Daniela

AU - Benbahouche, Nour El Houda

AU - Gostan, Thierry

AU - Vandermoere, Franck

AU - Robert, Marie Cécile

AU - Cusack, Stephen

AU - Verheggen, Céline

AU - Jensen, Torben Heick

AU - Bertrand, Edouard

PY - 2013

DA - 2013/11/24 00:00:00

PB - Springer Nature

SP - 1358-1366

IS - 12

VL - 20

SN - 1545-9993

SN - 1545-9985

ER -

BibTex |

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@article{2013_Hallais,

author = {Marie Hallais and Frédéric Pontvianne and Peter Refsing Andersen and Marcello Clerici and Daniela Lener and Nour El Houda Benbahouche and Thierry Gostan and Franck Vandermoere and Marie Cécile Robert and Stephen Cusack and Céline Verheggen and Torben Heick Jensen and Edouard Bertrand},

title = {CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing},

journal = {Nature Structural and Molecular Biology},

year = {2013},

volume = {20},

publisher = {Springer Nature},

month = {nov},

url = {https://doi.org/10.1038%2Fnsmb.2720},

number = {12},

pages = {1358--1366},

doi = {10.1038/nsmb.2720}

}

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MLA Copy

Hallais, Marie, et al. “CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing.” Nature Structural and Molecular Biology, vol. 20, no. 12, Nov. 2013, pp. 1358-1366. https://doi.org/10.1038%2Fnsmb.2720.

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Springer Nature

Journal

Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor

16.8

ISSN

15459993 (Print)
15459985 (Electronic)